CD38 regulates ovarian function and fecundity via NAD+metabolism
Rosalba Perrone,
Prasanna Vadhana Ashok Kumaar,
Lauren Haky
et al.
Abstract:SummaryMammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that CD38, a NAD+ consuming enzyme, is expressed in the ovarian extrafollicular space, primarily in immune cells, and its levels increase with reproductive age. Reproductively young mice lacking CD38 exhibit larger primordial follicle pools, elevated ovarian NAD+ lev… Show more
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