Etiology, pathology, management and prognosis of chronic pancreatitis in Chinese population: A retrospective study

Abstract

The purpose of this study was to investigate the etiology, pathological characteristics, management and prognosis of chronic pancreatitis in the Chinese population. The clinical data of 142 patients with chronic pancreatitis were retrospectively studied. All patients were of Chinese nationality and hospitalized from January 2008 to December 2011. Their ages ranged from 14 to 76 years, with a mean of 43 years. Of 142 patients, there were 72 cases of obstructive chronic pancreatitis (50.70%), 19 cases of alcoholic chronic pancreatitis (13.38%), 14 cases of autoimmune pancreatitis (9.86%) and 37 cases of undetermined etiology (26.06%). Pathologically, the average inflammatory mass diameter was 3.8 ± 3.3 cm, biliary obstruction occurred in 36 cases, gall stones in 70 cases, calcification in 88 cases, ductal dilatation in 61 cases, side branch dilatation in 32 cases, ductal irregularity in 10 cases, lymphocytic inflammation in 23 cases, obliterative phlebitis in 14 cases, extra pancreatic lesion in 19 cases and fibrosis in 142 cases. Location of pancreatic lesion in the region of head (n=97), neck (n=16), body (n=12), tail (n=15) and whole pancreas (n=2) influenced the choice of surgical procedures. Ninety-four patients (66.20%) received surgical treatment and 33.80% received other treatments. After operation, 80.85% of 94 patients experienced decreased pain, and 8.51% of 94 showed recovery of endocrine function but with a complication rate of 12.77%. All the operations were performed successfully. According to the pain scale of European Organization for Research and Treatment of Cancer (QLQ-C30) a decrease from 76 ± 22 to 14 ± 18 was observed. Etiology, pathological characteristics, management and prognosis of chronic pancreatitis in the Chinese population vary from others.

Etiologic Link Between Chronic Pancreatitis and Pancreatic Cancer; A Unicentric Experience of Pancreatic Disease Institute of Wuhan Union Hospital of China

“…(3) The lesion diameter was approximately the same in both diseases and the lesion site which was body and tail of pancreas was common ( figures 2A,2B,2C,2D). (4) The body and tail of pancreas as a location has been showed by many publications [1,13]. (5) The incidence of both diseases increased simultaneously in many countries [29,32].…”

“…The average diameter of the lesions was 3.6±3.2 in PC group and 3.8±3.3 in CP group as shown in table 1 and the most common lesions site was head of pancreas in both diseases. [1,15] Epidemiological report showed a parallel increase in both diseases in many countries. Niderau et al [16] found the prevalence of pancreatic cancer with CP to be 3.5 % and Lowenfel et al [17] showed a prevalence of 2.9%.…”

“…Pancreatic cancer (PC) and chronic pancreatitis (CP) are the second and third cause of hospitalization in the pancreatic surgery department of Wuhan Union Hospital of China [1]. PC is a devastating disease and fourth, fifth and seventh leading cause of cancer -related death in the United States, European Union and China, respectively [2].…”

S3-Leitlinie Pankreatitis – Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – September 2021 – AWMF Registernummer 021-003

“…Aber es bedarf höchstwahrscheinlich noch weiterer Faktoren, um die CP auszulösen (siehe 9.2.2.). Die Häufigkeit der autoimmunen Pankreatitis in CP-Kohorten liegt zwischen 4-9,8 %, ist aber in Asien viel häufiger als in Europa [355,356]. Eine Hypertriglyceridämie (> 1000 mg/dl) kann eine rezidivierende akute Pankreatitis bedingen, welche ohne Behandlung der Ursache möglicherweise im Verlauf Kriterien einer Diagnosestellung der CP erfüllt.…”