Etiology of Portal Hypertension in Children-An Experience in a Tertiary Centre of Bangladesh

Mahmud, Salahuddin; Ahmed, Syed Shafi; Gulshan, Jahida; Tasneem, Farhana

doi:10.3329/bjch.v39i1.28353

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…18 In another study Bangladesh, 80% of the children were noted to have PH due to pre-hepatic causes. 19 Poddar U et al 20 from India found extrahepatic portal venous obstruction to be the most common etiology of PH in children. In paediatric age group pre hepatic PH is common accounting for 30-50% of cases of variceal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Causes of portal hypertension in children.

Aftab¹,

Khurshid²,

Fayyaz³

et al. 2021

TPMJ

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Objective: To determine different causes of portal hypertension in children. Study Design: Cross Sectional study. Setting: Department of Pediatric Medicine, Department of Pediatric Gastroenterology and Department of Medical Emergency, The Children’s Hospital and Institute of Child Health, Multan. Period: 3rd April 2019 to 2nd October 2019. Material & Methods: A total of 71 children presenting with portal hypertension aged 1 month to 15 years of either gender were included. Newborns or children with congenital heart diseases were excluded. Patient samples were collected for complete blood counts and liver function tests, Ultrasound Abdomen and color Doppler ultrasonography were done for portal vein pressure to determine various causes of portal hypertension. Results: Overall, mean age was 9.00 ± 3.64 years. Out of the 71 patients, 51 (71.83%) were male and 20 (28.17%) were females. Different causes of portal hypertension were portal vein thrombosis in 48 (67.61%), liver cirrhosis in 14 (19.72%) and biliary atresia in 9 (12.68%) children. Conclusion: Among children having portal hypertension, portal vein thrombosis was noted to be the commonest cause followed by liver cirrhosis and biliary atresia.

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Section: Discussionmentioning

confidence: 99%

Causes of portal hypertension in children.

Aftab¹,

Khurshid²,

Fayyaz³

et al. 2021

TPMJ

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show abstract

“…One patient was Biliary cirrhosis and one patient had Auto immune hepatitis. Mahmud et al [18] studied 40 children with portal hypertension and found 32 (80%) due to pre-hepatic causes and 08 (20%) due to hepatic causes. Podder et al [19] studied portal hypertension in child and found extrahepatic portal hypertension in 54% cases.…”

Section: Discussionmentioning

confidence: 99%

Portal Hypertension in Children at the Department of Pediatric Gastroenterology & Nutrition, BSMMU, Dhaka, Bangladesh

ASMB,

et al. 2023

Glob Acad J Med Sci

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Background: Portal hypertension is the hemodynamic abnormality frequently associated with serious liver disease, although it is recognized in a variety of extrahepatic diseases also. Portal hypertension is an important cause of morbidity and mortality in Bangladeshi children. Development of esophageal varices and bleeding is one of the major complications of CLD. The mortality from each episode of variceal bleeding is 30-50% depending on the clinical status of the patient. All conditions that interfere with blood flow at any level within the portal system can lead to portal hypertension. For better management of this disorder, it is important to determine the underlying cause. Objective: To assess the portal hypertension in children at the Department of Pediatric Gastroenterology & Nutrition, BSMMU, Dhaka, Bangladesh. Methods: This cross-sectional descriptive study was conducted at the Department of Pediatric Gastroenterology & Nutrition, BSMMU during the period Jan 2018 to July 2019. 50 patients who were diagnosed as portal hypertension were determined by Upper GI Endoscopy. Doppler USG was also done for supporting the diagnosis of Portal HTN as well as to differentiate between extrahepatic Portal HTN and CLD with portal HTN. Demographic data and other related information regarding etiology and complications were recorded in a standard datasheet. Results: Results: A total of 50 cases were included in this study. Their age range was 1.5-16 years. It was observed that 21 (42.0%) patients belonged to age group 6-10 years. The mean age was 9.22±9.85 years with ranged from 2.5 to 16 years. It was observed that almost two third 31 (62.0%) patients were male and 19 (38.0%) were female. Among 50 patients 29 were diagnosed as extrahepatic portal hypertension and 21 were diagnosed as CLD with portal HTN. Shows the etiology of portal hypertension of studied patients. Extrahepatic portal hypertension was the most common etiology (58.0%). Among CLD patients Wilson disease was the most common (13; 26.0%). Two (4.0%) patients were cryptogenic CLD and two (4.0%) were Budd Chiari Syndrome. One patient was Biliary cirrhosis and one patient had Auto immune hepatitis. Conclusion: We concluded that Extrahepatic Portal HTN is the most common cause of portal hypertension in children in this center. Among the intrahepatic causes of portal HTN Wilson disease was the

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“…Portal hypertension (PH), a serious complication of liver disease, refers to a clinical syndrome characterized by an elevation in the pressure gradient between the portal and hepatic veins (1). Given that the normal portal pressure is less than or equal to 5 mmHg, a pressure gradient of 6 mmHg or more is defined as PH (2).…”

Section: Introductionmentioning

confidence: 99%

Etiology, Presenting Features, and Endoscopic Findings of Portal Vein Hypertension in Children

et al. 2023

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Background: Portal hypertension (PH) refers to a clinical syndrome characterized by an elevation in the pressure gradient between the portal and hepatic veins. It is necessary to identify the underlying causes to manage this disorder effectively. Objectives: This study aimed to investigate the etiology, clinical manifestations, and endoscopic findings in children with PH. Methods: This analytic cross - sectional study was performed on patients (< 18 years) with PH who were referred to the Pediatric Gastroenterology Clinic of Mofid Children’s Hospital in Tehran, Iran, within 2014 - 2020. The demographic details of the patients were collected from their medical records. Clinical manifestations, age at diagnosis, family history, and endoscopic findings were also recorded. Results: A total of 102 patients participated in this study. The subjects’ mean age was 6.81 ± 4.46 years. The results revealed that 50 (49.0%) and 46 (45%) cases had PH due to extrahepatic and intrahepatic diseases, respectively. Autoimmune hepatitis and portal vein thrombosis were the most common etiology of intrahepatic and extrahepatic PH, respectively. Based on the endoscopic analysis, esophageal varices were the most common findings (95.8%) observed in patients with PH. Conclusions: Extrahepatic diseases were the most prevalent PH etiology in children referred to the Pediatric Gastroenterology Clinic of Mofid Children’s Hospital.

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Etiology of Portal Hypertension in Children-An Experience in a Tertiary Centre of Bangladesh

Cited by 5 publications

References 10 publications

Causes of portal hypertension in children.

Causes of portal hypertension in children.

Portal Hypertension in Children at the Department of Pediatric Gastroenterology & Nutrition, BSMMU, Dhaka, Bangladesh

Etiology, Presenting Features, and Endoscopic Findings of Portal Vein Hypertension in Children

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