Etiology of increased albumin synthesis in old rats

Obenrader, Mark; Chen, J.; Ove, Peter; Lansing, Albert I.

doi:10.1016/0531-5565(74)90034-5

Cited by 11 publications

(1 citation statement)

References 8 publications

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“…One of the possible explanations for the increase in albumin synthesis was that the liver had to compensate for an increase in albumin excretion via the urine due to kidney insufficiency, as suggested by Beauchene et al (1970). Indeed, in a variety of rat strains, an increase in urinary excretion of albumin with age was found (Beauchene et al, 1970;Obenrader et al, 1974;Alt et al, 1980). However, very little attention was paid to age-related changes in total albumin elimination.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in albumin elimination in female WAG/Rij rats

Horbach¹,

Yap²,

Bezooijen³

1983

Biochemical Journal

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Albumin elimination rates were determined in 3-, 12-, 24- and 36-month-old female WAG/Rij rats. No change in elimination half-life was found with age. However, as there was an increase in the whole-body albumin pool, a concomitant increase in albumin clearance was observed at between 12 and 36 months of age. It was concluded that the increase in clearance between 12 and 24 months of age was only due to a change in the animal's physiology, whereas between 24 and 36 months of age it was also due to changes in the albumin molecule. The age-related changes in albumin clearance were thought not to be caused by changes in the albumin excretion via the urine or via the gastrointestinal tract.

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