Chromatin proteins and cellular aging The relationship between aging and protein synthesis RNA synthesis Protein synthesis and degradation during aging and senescence Aging and transcription Age-related changes in protein synthesis Enzymes, enzyme alteration, and protein turnover Age-related changes in the structure and function of chromatin Macromolecular methylation during aging The effect of age and nutrition on protein synthesis by cells and tissues from mammals Levels of specific messenger RNA species as a function of age Aging and gene expression Age-related changes of transcription and RNA processing Age-related changes in the synthesis of individual liver-specific proteins Effect of aging on translation and transcription Implication of protein oxidation in protein turnover, aging, and oxygen toxicity Biochemical markers of aging Protein oxidation and aging DNA methylation in aging and cancer RNA and protein metabolism in the aging brain Alterations in gene expression with aging Protein synthesis and the components of protein synthetic machinery during cellular ageing Effect of age on liver protein synthesis and degradation The next frontier: studies of the effects of age and diet on mammalian gene expression Protein synthesis, posttranslational modifications, and aging Gene expression and aging ~ TABLE 9.3. Effect of Age on the mRNA Levels in Liver