Impact of Aging on Protein Metabolism

Young, Vernon R.

doi:10.1007/978-1-4612-5272-6_3

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…Whole body protein turnover can account for between 15 and 20% of the BMR (34,39,45,47), and a reduced turnover of protein has been demonstrated in older individuals (48). In addition, data suggest that the contribution of skeletal muscle to whole body protein turnover decreases with age, with a relatively larger contribution from the visceral organs in the elderly (25,50,51).…”

Section: Possible Mechanisms Underlying the Reduction In Bmrmentioning

confidence: 99%

Is there evidence for an age-related reduction in metabolic rate?

Piers

Soares

McCormack

et al. 1998

Journal of Applied Physiology

153

105

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To determine whether the age-related reduction in basal metabolic rate (BMR) is explained by a quantitative and/or qualitative change in the components of lean tissue, we conducted a cross-sectional study in groups of young (n = 38, 18-35 yr) and older (n = 24, 50-77 yr) healthy individuals. BMR was measured by indirect calorimetry. Body composition was obtained by using dual-energy X-ray absorptiometry (DEXA), which permitted four compartments to be quantified [bone mineral mass, fat mass (FM), appendicular lean tissue mass (ALTM), and nonappendicular lean tissue mass (NALTM)]. Absolute BMR and ALTM were lower, whereas FM was significantly higher in the older, compared with young, subjects. BMR, adjusted for differences in FM, ALTM, and NALTM, was significantly lower in the older subjects by 644 kJ/day. In separate regression analyses of BMR on body compartments, older subjects had significantly lower regression coefficients for ALTM and NALTM, compared with young subjects. Hence, the age-related decline in BMR is partly explained by a reduction in the quantity, as well as the metabolic activity, of DEXA-derived lean tissue components.

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