Etiology-Based Decision-Making Protocol for Pediatric Cholelithiasis

Agrawal, Vikesh; Tiwari, Afy; Sharma, Dhananjaya; Agrawal, Rita

doi:10.1007/s13312-021-2280-9

Cited by 6 publications

(8 citation statements)

References 14 publications

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“…Внутренние причины зачастую не поддаются коррекции, к ним относятся: пол, возраст, наследственность и так далее. Внешние состоят из совокупности факторов окружающей среды (от качества питьевой воды и пищи до инсоляции), а также от особенностей самого организма человека [4]. Начать повествование о причинах развития холелетиаза стоит с рассмотрения факторов, влияющих на организм извне.…”

Section: патогенетические факторы жкбunclassified

“…В развитии ЖКБ принимает участие множество факторов, немалое значение имеют генетические факторы [1]. Так к основным причинам развития желчнокаменной болезни в педиатрической практике относят, в первую очередь, нарушение синтеза первичных желчных кислот [4]. Это происходит вследствие недостаточной работы ферментов (например, CYP27A1 и CYP7A1), участвующих в синтезе первичных желчных кислот [7].…”

Section: внутренние факторыunclassified

“…При глюкуронировании непрямого (неконъюгированного) билирубина, образующийся продукт реакции (прямой/конъюгированный билирубин) обладает большей гидрофильностью, что способствует его выведению из организма. Избыточное содержание в желчи билирубина приводит к её сгущению, то есть увеличивается литогенность желчи [4].…”

Section: уридиндифосфат-глюкуронилтрансферазаunclassified

“…Доклиническая стадия отличается тем, что у пациента отсутствуют признаки билиарной обструкции, осложнения со стороны поджелудочной железы, билиарная боль и др. На данном этапе может быть очень эффективен консервативный подход, в частности, пробная литолитическая терапия урсодезоксихолевой кислотой [4]. Это вещество приводит в равновесие концентрации желчных кислот -уменьшает количество токсичных желчных кислот, в частности хенодезоксихолевую кислоту.…”

Section: уридиндифосфат-глюкуронилтрансферазаunclassified

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Relationship between cholelithiasis and metabolic syndrome: the role of genetic factors

Novikova

Shrayner

Лифшиц

et al. 2022

jour

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The incidence of gallstone disease (GSD) and metabolic syndrome (MS) is increasing every year. The ICD-10 does not have the diagnosis of “metabolic syndrome” and it has been coded on the basis of the diseases despite its wide prevalence now. These are multifactorial diseases, the pathogenesis of which is intertwined and mutually aggravate their courses. There are both external and internal reasons of forming the stones in the biliary tract. Genetic factors play a significant role in the internal causes of cholelithiasis. The genetic characteristics of the patient allow to work out a personalized approach. It increases the success of drug therapy. MS is one of the main predisposing factors for the development of cholelithiasis. It also leads to more severe course of the latter. The pathogenetic mechanisms of the patologies developments are considered in the article presented with the special attention paid to the genetic component of cholelithiasis.

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Section: патогенетические факторы жкбunclassified

Section: внутренние факторыunclassified

Section: уридиндифосфат-глюкуронилтрансферазаunclassified

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Relationship between cholelithiasis and metabolic syndrome: the role of genetic factors

Novikova

Shrayner

Лифшиц

et al. 2022

jour

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“…The incidence of cholelithiasis is constantly increasing in the pediatric population, ranging from 1.9% to 4% [ 1 , 2 ]. Factors that predispose to the development of cholelithiasis include hemolytic disorders, ceftriaxone therapy, total parenteral nutrition (TPN), cystic fibrosis, obesity, genetic predisposition and hipercholesterolemia [ 3 ]. However, obesity is not only a growing problem in the pediatric population worldwide, but is also the most common cause of cholelithiasis in children today [ 1 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Sphingolipids in Pediatric Patients with Cholelithiasis—A Preliminary Study

Zdanowicz

Bobrus-Chociej

Błachnio-Zabielska

et al. 2022

JCM

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(1) Background: Disturbances in the sphingolipid profile are observed in many diseases. There are currently no data available on the evaluation of sphingolipids and ceramides in cholelithiasis in children. The aim of this study was to evaluate the concentrations of sphingolipids in the sera of pediatric patients with gallstones. We determined their relationship with anthropometric and biochemical parameters. (2) Methods: The concentrations of sphingolipids in serum samples were evaluated using a quantitative method, ultra-high-performance liquid chromatography–tandem mass spectrometry. (3) Results: The prospective study included 48 children and adolescents diagnosed with gallstones and 38 controls. Serum concentrations of total cholesterol (TC); sphinganine (SPA); ceramides—C14:0-Cer, C16:0-Cer, C18:1-Cer, C18:0-Cer, C20:0-Cer and C24:1-Cer; and lactosylceramides—C16:0-LacCer, C18:0-LacCer, C18:1-LacCer, C24:0-LacCer and C24:1-LacCer differed significantly between patients with cholelithiasis and without cholelithiasis. After adjusting for age, gender, obesity and TC and TG levels, we found the best differentiating sphingolipids for cholelithiasis in the form of decreased SPA, C14:0-Cer, C16:0-Cer, C24:1-LacCer and C24:0-LacCer concentration and increased C20:0-Cer, C24:1-Cer, C16:0-LacCer and C18:1-LacCer. The highest area under the curve (AUC), specificity and sensitivity were determined for C16:0-Cer with cholelithiasis diagnosis. (4) Conclusions: Our results suggest that serum sphingolipids may be potential biomarkers in pediatric patients with cholelithiasis.

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Ceftriaxone

2021

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Etiology-Based Decision-Making Protocol for Pediatric Cholelithiasis

Cited by 6 publications

References 14 publications

Relationship between cholelithiasis and metabolic syndrome: the role of genetic factors

Relationship between cholelithiasis and metabolic syndrome: the role of genetic factors

Analysis of Sphingolipids in Pediatric Patients with Cholelithiasis—A Preliminary Study

Ceftriaxone

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