Etiology and Epidemiology of Children With Acute Otitis Media and Spontaneous Otorrhea in Suzhou, China

Ding, Yi-min; Geng, Qian; Tao, Yunzhen; Lin, Yuzun; Wang, Yunzhong; Black, Steven; Li, Xiaopan; Zhang, Tao

doi:10.1097/inf.0000000000000617

Cited by 24 publications

(20 citation statements)

References 33 publications

(41 reference statements)

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“…Another Russian study found that the rate of unjustified outpatient antibiotic prescriptions in children with respiratory infections was estimated at 40% 27. In PCV-unimmunised Chinese children with pneumococcal AOM, a significant proportion of clones were also resistant to antibiotics 28. In India, otolaryngologists reported that they treated 98% of AOM episodes with antibiotics, and amoxicillin/clavulanic acid was the first-line therapy 29.…”

Section: Discussionmentioning

confidence: 99%

Acute otitis media guidelines in selected developed and developing countries: uniformity and diversity

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Acute otitis media guidelines in selected developed and developing countries: uniformity and diversity

et al. 2016

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“…The strains of nonsurvivors in this study were multi-drug resistant. Domestic and foreign reports also showed that S. pneumoniae was generally multi-drug resistant, and the resistance to penicillin and cephalosporins increased [ 6 , 26 , 27 ]. Compared with drug sensitivity analysis in the present study, a better consistency rate was achieved if the choice of antibiotics strictly abided by China’s “Guidelines for the Management of Community Communicable Pneumonia (2013 Revision)”.…”

Section: Discussionmentioning

confidence: 99%

Early clinical predictors for the prognosis of invasive pneumococcal disease

Guo

et al. 2020

BMC Infect Dis

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Background Risk factors related to mortality due to invasive pneumococcal disease (IPD) have been unveiled previously, but early clinical manifestations of IPD based on prognosis remain uncovered. Methods The demographic characteristics, clinical features, serotype, antibiotic susceptibility, and outcomes of 97 hospitalized children with laboratory-confirmed IPD from Suzhou, China, were collected and analyzed retrospectively. Results The median age was 0.69 (0.49–1.55) years in the non-survivor group compared with 2.39 (0.90–3.81) years in the survivor group. The mortality of 97 children with laboratory-confirmed IPD was 17.5% (17/97), and 53.6% of them were aged less than 2 years. Pathogens were mainly from the blood and cerebrospinal fluid, and sepsis was the most frequent type. Statistically significant differences were found in hyperpyrexia, vomiting, anorexia, lethargy, poor perfusion of extremities, Hb level, and Plt count between the nonsurvival and survival groups. Further, the multivariate regression analysis showed that early signs, including hyperpyrexia, vomiting, anorexia, lethargy, and poor perfusion of extremities, were independent risk factors for the in-hospital mortality of children with laboratory-confirmed IPD. The mortality was also associated with antimicrobial sensitivity in pneumococcal isolates. The microbes in 1/17 (5.9%) children who were prescribed an antibiotic showed antimicrobial sensitivity in the nonsurvival group, compared with 21/80 (26.3%) children who survived. The most common serotypes identified were 6B (35.3%, 6/17), 14 (23.5%, 4/17), 19F (23.5%, 4/17), 19A (5.9%, 1/17), 23F (5.9%, 1/17), and 20 (5.9%, 1/17) in the nonsurvival group. The coverage of IPD serotypes of the 7-valent pneumococcal conjugate vaccine (PCV7) was 88.2% (15/17), while that of the 13-valent S. pneumoniae vaccine (PCV13) was 94.1% (16/17) of the coverage in the nonsurvival group. Conclusions Recurrent hyperpyrexia, vomiting, anorexia, lethargy, and poor perfusion of extremities in the early stage were independent predictors for the in-hospital mortality of children with laboratory-confirmed IPD. Appropriate use of antibiotics and PCV immunization were the keys to improve the outcome of IPD.

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“…In the current study, Pseudomoans aeruginosa (22.4%; 62) was isolated maximum, followed by 19 . In the current study, 31 (11.2%) Streptococcus pneumoniae were isolated.…”

Section: Discussionmentioning

confidence: 99%

"Study on Aerobic Bacteria Causing Chronic Suppurative Otitis Media among the Pediatric Age Group"

2017

IJCRR

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Objectives: Chronic suppurative otitis media (CSOM) was reported to be the major cause of childhood morbidity. Recurrent ear discharge is the commonest clinical presentation. With these, a study was conducted to find the aerobic bacterial as well as fungal profile among the school going children Methods: Study was conducted in the department of Microbiology and ENT, GSL Medical College, Rajahmundry from February 2017 to July 2017. Children with ear discharge were selected for the study. An informed written consent was obtained from the parents of all the participants. Study protocol was approved by the Institutional Ethics committee. Aural swabs were collected and send to the Microbiology laboratory for aerobic culture and sensitivity test.Results: Microorganisms were isolated from 98% (219) samples. Gram negative bacilli (46.6%; 129) were isolated maximum, followed by Gram positive cocci (41%; 114) and fungi (12.3%; 34). Pseudomonas aeruginosa (62; 22.4%) was the leading cause of CSOM. Conclusion:Decreased sensitivity was detected to Gentamycin and Cotrimoxazole, commonly used antibiotics in the form of ear drops. Hence antibiotic susceptibility testing is always advisable.

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Etiology and Epidemiology of Children With Acute Otitis Media and Spontaneous Otorrhea in Suzhou, China

Abstract: S. pneumoniae was a leading cause for AOM in children in Suzhou, China. Antibiotics resistance rates of S. pneumoniae were high and mainly due to the spread of CC271 clonal complex.

Cited by 24 publications

References 33 publications

Acute otitis media guidelines in selected developed and developing countries: uniformity and diversity

Acute otitis media guidelines in selected developed and developing countries: uniformity and diversity

Early clinical predictors for the prognosis of invasive pneumococcal disease

"Study on Aerobic Bacteria Causing Chronic Suppurative Otitis Media among the Pediatric Age Group"

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