Etiology analysis and computed tomography imaging of a tonsillar inflammatory myofibroblastic tumor: report of an immunocompetent patient and brief review

Luo, Yun-Zhen; Dai, Li‐Bo; Zhou, Shui‐Hong; Luo, Xing-Mei; Fan, Jun; Ruan, Lifang

doi:10.1186/1758-3284-4-4

Cited by 1 publication

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References 17 publications

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“…In our study, all masses were solid and no evidence of cystic or necrotic change was found. Despite their apparently benign morphological nature, IMTs have been reported to have locally aggressive growth behavior (10,14). In our study, 80% (8/10) of the masses had aggressive, lobulated appearances, with unclear margins on MRI.…”

Section: Discussionmentioning

confidence: 62%

MRI characterization of inflammatory myofibroblastic tumors in the maxillofacial region

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et al. 2014

Diagn Interv Radiol

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HEAD AND NECK IMAGINGORIGINAL ARTICLE PURPOSE We aimed to investigate the magnetic resonance imaging (MRI) appearance of inflammatory myofibroblastic tumors (IMTs) in the maxillofacial region in order to improve diagnostic quality and resection efficacy. MATERIALS AND METHODSTen cases of pathologically identified IMTs were analyzed by MRI. The MRI features were examined, including tumor location, tumor shape, tumor margins, and involvement of the surrounding tissues. RESULTSOf ten masses investigated in this study, eight masses were irregular neoplasms with unclear margins and two masses, in the parotid gland, were regular neoplasms with clear margins. Precontrast T1-weighted images of all ten masses exhibited isointense signals compared to the adjacent tissue, while contrast-enhanced T1-weighted images showed strong enhancement. Six masses were hypointense and four masses were slightly hyperintense in T2-weighted images. Involvement of the adjacent structures was observed in eight of ten cases. Meanwhile, two patients experienced intracranial involvement. CONCLUSIONIMTs are rare tumors in the maxillofacial region, displaying a number of distinct MRI characteristics. Most importantly, they display low T2 signal intensity and strong enhancement, and they frequently invade surrounding structures. Thus, MRI can improve the accuracy of IMT diagnoses and provide critical information for surgical planning. Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms composed of myofibroblasts accompanied by prominent small lymphocytes and plasma cells (1). They have previously been categorized in the inflammatory pseudotumor group, but they are now defined as a separate entity based on electron microscope and immunohistochemical findings. Recent studies have shown that cytogenetic clonal abnormalities and anaplastic lymphoma kinase expression are the best definitive markers for diagnosing IMTs (2, 3). IMTs most commonly involve the lung, although they have been described in almost all sites in the body, in both sexes, and at all ages (4). IMTs in the maxillofacial region are exceptionally rare, and the clinical presentation depends on the location of the tumor. Patients can present with fever, pain, swelling, otorrhea, and cranial nerve palsy (5). IMTs clinically mimic malignant lesions, and the clinical significance lies in the difficulty encountered in excluding malignancy, preoperatively. There have been only a few studies that reported substantial numbers of IMTs in the maxillofacial region. Recently, Yuan et al. (6) reported imaging findings for eight IMT cases in the maxillary sinus; however, only three of the patients underwent MRI analysis, and the researchers could not summarize the MRI characteristics. Therefore, we have retrospectively analyzed the MRI findings of ten cases with maxillofacial IMT and summarized the imaging features in order to improve the diagnosis of this tumor. Material and methods PatientsA total of ten patients with pathologically confirmed IMTs in the maxillofacial region were reviewe...

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Section: Discussionmentioning

confidence: 62%