Etiologies of chronic liver diseases in Hong Kong

Fung, Konrad; Fung, James; Lai, Ching–Lung; Yuen, Man‐Fung

doi:10.1097/meg.0b013e3281ace0b7

Cited by 27 publications

(26 citation statements)

References 21 publications

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“…This retrospective study identified 147 patients diagnosed with PBC at Beijing You'an Hospital between October [16,17]. The prevalence rates of PBC vary widely among different geographical areas, and have been reported to be as high as 402/million in the northern US [18].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors and Survival Analysis of Antimitochondrial Antibody-Positive Primary Biliary Cirrhosis in Chinese Patients

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Prognostic Factors and Survival Analysis of Antimitochondrial Antibody-Positive Primary Biliary Cirrhosis in Chinese Patients

et al. 2011

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“…A study in Taiwan showed that chronic HBV infection is associated with a 98-fold higher risk for HCC. 4 In Hong Kong, approximately 8% of the general population is HBV carriers 5 and HCC ranks the fourth most common cancer in our general population. 6 HCC-related mortality is high because of its delayed presentation and surgical cure of HCC relies on early diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular carcinoma after kidney transplantation: analysis of Hong Kong Renal Registry

et al. 2014

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Kidney transplant recipients have increased risk of cancers when compared with the general population. Hepatocellular carcinoma (HCC) is extremely important in Asia where hepatitis B virus (HBV) infection is endemic. The aim is to study the epidemiological and clinical aspects of all de novo HCC in our kidney transplant recipients. Moreover, various preventive strategies which may help to optimize the outcome will also be discussed. A retrospective review of all patients who developed HCC after kidney transplantation between May 1972 and December 2011 in Hong Kong, based on the data from Hong Kong Renal Registry. After a follow-up period of 40,246 person-years, 20 patients (males 15: females 5) developed HCC. The annual incidence was 49.7/100,000 persons per year. Among them, 16 were HBV carriers, 2 were hepatitis C (HCV) carriers and 2 had HBV and HCV co-infection. Presence of HBV infection was associated with 78-fold higher risk for HCC development. Majority (85%) were asymptomatic when HCC was diagnosed by ultrasound or alpha-fetoprotein surveillance. All patients diagnosed by surveillance received active treatment while 2/3 of symptomatic patients could only receive symptomatic care and died rapidly. In conclusion, HBV infection is the major etiological factor for HCC development in kidney transplant recipients in HBV endemic areas. Regular HCC surveillance appeared to be able to detect early stage cancers which are amenable to treatment and offer the best hope of cure.

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“…Excessive alcohol consumption is the primary cause of liver disease in most countries, and to date, there is no satisfactory therapeutic drug (Fung et al, 2007). As a severe hepatotoxicant, alcohol causes alcoholic liver disease (ALD), which is associated with a spectrum of liver injury ranging from steatosis and steatohepatitis to fibrosis and cirrhosis (Tilg and Day, 2007;O'Shea et al, 2010;An et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Triterpenoid Isolated from Schizandra chinensis against Acute Alcohol-Induced Liver Injury in Mice

Zhu

Liu

et al. 2013

FSTR

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Schizandra chinensis (Turcz.) Baill (SC) is useful for the regulation of various pathological conditions in Northeast Asia and is known to possess antioxidant activity. Here, triterpenoid of SC (TSC) was isolated from ethanol-water extracts of SC by using an octadecylsilyl column and shown to be one of the major active constituents of SC. The hepatoprotective effects of TSC in a mouse model of acute alcohol-induced liver injury (AALI) were evaluated based on serum biochemical indicators and antioxidative capacity. Severe liver damage caused by alcohol intake with increasing activation of hepatic markers was decreased in the group of mice fed TSC, and the results were confirmed through hematoxylin and eosin staining. Serum biochemical indicators and antioxidative capacity were decreased by alcohol but recovered by TSC. Furthermore, TSC increased the activity of antioxidant enzymes and reduced inflammatory reactions. The experimental results indicate that TSC has preventive and therapeutic effects against AALI.Keywords: Schizandra chinensis, triterpenoid, acute alcohol-induced liver injury, mice, octadecylsilyl *To whom correspondence should be addressed. E-mail: mengxjsy@126.com IntroductionExcessive alcohol consumption is the primary cause of liver disease in most countries, and to date, there is no satisfactory therapeutic drug (Fung et al., 2007). As a severe hepatotoxicant, alcohol causes alcoholic liver disease (ALD), which is associated with a spectrum of liver injury ranging from steatosis and steatohepatitis to fibrosis and cirrhosis (Tilg and Day, 2007;O'Shea et al., 2010;An et al., 2012). ALD is associated with increased production of proinflammatory cytokines/chemokines and imbalanced immune responses (Tilg and Diehl, 2000;McClain et al., 2004), and alcohol-induced oxidative stress is caused by 3 ethanol metabolic pathways that involve alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase (Das and Vasudevan, 2007). Alcohol is metabolized by alcohol dehydrogenase to form acetaldehyde, which is processed to generate free radicals . Peroxisomal activity also results in ethanol oxidation in the liver and may be more obvious in heavy ethanol consumers, who show accumulation of fatty acids in the liver because of increased fatty acid peroxisomal oxidation (Koch et al., 2004).Schizandra chinensis (Turcz.) Baill (SC, Wuweizi in China) is a member of the Magnoliaceae family that occurs in the Northeast Asia (Hancke et al., 1999). It has been regarded as a useful material in the treatment of various pathological conditions over the last several decades in China, Korea, and Japan. The fruits and stems of SC are listed officially as a food and herbal medicine in the Chinese Pharmacopeia, and they have thus been widely added to functional foods and used to treat a variety of diseases (Lee et al., 2009). SC is known to contain a variety of bioactive constituents, including triterpenoid, lignans, polysaccharides, and sterols (Peng et al., 2005). Triterpenoids are among the major functional comp...

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Etiologies of chronic liver diseases in Hong Kong

Cited by 27 publications

References 21 publications

Prognostic Factors and Survival Analysis of Antimitochondrial Antibody-Positive Primary Biliary Cirrhosis in Chinese Patients

Prognostic Factors and Survival Analysis of Antimitochondrial Antibody-Positive Primary Biliary Cirrhosis in Chinese Patients

Hepatocellular carcinoma after kidney transplantation: analysis of Hong Kong Renal Registry

Hepatoprotective Effects of Triterpenoid Isolated from Schizandra chinensis against Acute Alcohol-Induced Liver Injury in Mice

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