Etiological Role of Ferritin and Vitamin D in Patients with Telogen Effluvium

Mohammad, Noha Ezzat; Ibrahium, Radawa Said; Mohammed, Mohamad Hassan; Galal, Sara Ahmed; Maher, Rehab; Darwish, Hanan Ali

doi:10.4172/2155-9554.1000431

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…There was no significant association between occurrence of the disease and job or residency of the patients (P value =0.283 and 0.069, respectively; Table 2). Although, in current study, vitamin D level was significantly associated with duration and symptoms of telogen effluvium (P=0.046; Table 3), this finding was inconsistent with another study that suggested that there was no significant relation between level of vitamin D and duration of the disease (22,23). Vitamin D level among patients in acute phase was significantly higher than that among those with chronic phase (11.68±4.77ng/ml and 9.93±3.55ng/ml, respectively, P value=0.046; Table 3).…”

Section: Resultscontrasting

confidence: 98%

Vitamin D level and telogen hair loss: A Case control study

Turkan¹,

Al-Rawi

2021

JFacMedBagdad

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Abstract Background: Hair loss is a common skin condition. Hair is not a vital organ but losing it has a worse effect on the psychological state of the patient and may interrupt his daily social activities. Telogen effluvium founded to be the commonest noninflammatory cause to diffuse hair loss. Since nutritional disturbances are one of the triggering factors for it. It might be useful in the management of TE Due to the limited number of studies& little information is available on this subject possible role of vitamin D or its deficiency should be studied further. Aim of the study: to determine the association between Telogen effluvium and vitamin D level. Materials and methods: This is a case-control study performed in a period between December 2018 until June 2020; in Baghdad dermatology center at medical city. One hundred women who were seeking treatment for diffuse hair shedding and who hadn’t received treatment or supplements yet and One hundred fifty control subjects are chosen from patients who were referred to the dermatology clinic for the treatment of nevi and who are not pregnant or lactating, had no systemic or local scalp diseases are included in the study. Full History, physical examination performed for all cases including looking for cutaneous diseases, supplements & drug intake. Serum Vitamin D3 is measured using (Ichroma (TM), Boditech Med Inc., Korea). Result: A total of 250 females were included in this study, 100 of them got telogen effluvium & 150 were patients who attend dermatology clinic seeking treatments for nevi or skin tag (control group) .The mean age of cases was (22.59 ±4.837 year) that wasn’t significantly different from mean age of control group (23.647±6.022 years) (p-value =0.127). The mean level of Vitamin D was significantly lower than that of control group (11.16±4.49) Vs (18.98±10.65), P value <0.001. Vitamin D mean level in acute phase was significantly higher than that of chronic phase pts. (11.68±4.77 & 9.93 ±3.55 respectively), p value=0.04. Mean vit. D among symptomatic patients. (9.7 ± 3.5) was significantly lower than that among asymptomatic pts. (13±4.19) (p=0.001).No significant association were noticed between job & residence of the patients of both groups, (P-value =0.283 & 0.069 respectively (. Conclusion: Age mean difference was not significant among cases and controls. Deficiency in vitamin D may assume a possible leading cause of telogen effluvium among women with hair loss. Cases were significantly associated with low level of Vitamin D3 than controls.Low level of vitamin D was dominant among housewives, urban women, and among symptomatic patients with acute duration.

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Section: Resultscontrasting

confidence: 98%

Vitamin D level and telogen hair loss: A Case control study

Turkan¹,

Al-Rawi

2021

JFacMedBagdad

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“…In all telogen effluvium patients, the hair pull test was positive all over the scalp (including frontal, 2 temporal and occipital regions). Also Telogen effluvium cases showed significantly higher vertex, occiput, right, left temporal, hair pull test when compared to control group Table (2).…”

Section: Results and Discussion 31 Clinical Resultsmentioning

confidence: 93%

“…Many mechanisms are impeded as severe fever, pregnancy, chronic systemic diseases, horrible hemorrhage, crash diet, sudden starvation, nutritional deficiency, accidental trauma, surgical operations and severe emotional stress. TE may be acute or chronic, if hair shedding lasts less than 6 months so it is acute TE, while chronic TE is hair shedding lasting longer than 6 months [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Levels of Vascular Endothelial Growth Factor (VEGF) in Female Patients with Telogen Effluvium

Refaey

Behiry

Mansour

et al. 2018

Benha Journal of Applied Sciences

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Telogen effluvium is a form of non-scarring diffuse hair loss. It is characterised by premature entrance of a large number of hairs into telogen phase at one time. In recent years, many growth factors participate in the hair follicle cycle regulation and promote hair growth. Vascular endothelial growth factor (VEGF) is one of the growth factors stimulating angiogenesis and its disturbance may lead to telogen effluvium. Evaluation of serum levels of VEGF in female patients with telogen effluvium.Serum VEGF concentrations were measured in 40 consecutive women with telogen effluvium aged between 18 and 65 years in comparison with 40 women without hair loss using enzyme-linked immunosorbent assay (ELISA). Serum levels of VEGF were found to be lower in female patients than in healthy controls.Decreased serum levels of VEGF in female patients than in controls probably reflect the role of VEGF in the pathogenesis of telogen effluvium.

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Oral Vitamin D Treatment in Patients with Telogen Effluvium: Clinical and Dermoscopic Evaluation

El-Tatawy,

Gheida,

Soliman

et al. 2023

International Journal of Trichology

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Background: Telogen effluvium (TE) is the most common hair loss. Vitamin D is related to hair and skin diseases due to its immunomodulatory and anti-inflammatory effects. Objective: To investigate Vitamin D serum level role in TE pathogenesis. Patients and Methods: Forty females with TE were collected and twenty age- and sex-matched healthy individuals as controls. Serum 25(OH) Vitamin D level was estimated prior and 3 months after oral Vitamin D. Results: The mean serum 25(OH) Vitamin D levels were significantly lower in TE patients than controls (13.31 ± 5.8 ng/ml vs. 33.61 ± 8.16 ng/ml) respectively, P < 0.001. The mean serum 25(OH) Vitamin D levels before treatment in acute TE was 12.31 ± 6.88 ng/ml, compared to 10.6 ± 3.9 ng/ml in chronic TE without a significant difference, (P = 0.544). The mean serum 25(OH) Vitamin D levels in TE group after 3 months oral Vitamin D therapy were 38.4 ± 15.22 ng/ml with significant increase compared to pretreatment level, (P < 0.001). However, without a significant difference between acute TE (45.4 ± 9.22 ng/ml) and chronic TE (42.1 ± 10.6 ng/ml), (P = 0.711). Conclusion: Oral Vitamin D has a promising effect in TE treatment, but the results need to be verified on a larger scale with evidence-based recommendation regarding the exact dose and treatment duration.

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Etiological Role of Ferritin and Vitamin D in Patients with Telogen Effluvium

Abstract: Introduction: Telogen effluvium (TE) is an abnormality of hair cycling that result in an abrupt onset of generalized shedding of telogen hairs from the scalp, with or without an entifiable trigger. Ferritin and vitamin D play an important role in hair follicle differentiation.

Cited by 3 publications

References 21 publications

Vitamin D level and telogen hair loss: A Case control study

Vitamin D level and telogen hair loss: A Case control study

Evaluation of Serum Levels of Vascular Endothelial Growth Factor (VEGF) in Female Patients with Telogen Effluvium

Oral Vitamin D Treatment in Patients with Telogen Effluvium: Clinical and Dermoscopic Evaluation

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