Vitamin D level and telogen hair loss: A Case control study

Abstract

Abstract
 
 Background: Hair loss is a common skin condition. Hair is not a vital organ but losing it has a worse effect on the psychological state of the patient and may interrupt his daily social activities. Telogen effluvium founded to be the commonest noninflammatory cause to diffuse hair loss. Since nutritional disturbances are one of the triggering factors for it. It might be useful in the management of TE Due to the limited number of studies& little information is available on this subject possible role of vitamin D or its deficiency should be studied further.
 Aim of the study: to determine the association between Telogen effluvium and vitamin D level.
 Materials and methods: This is a case-control study performed in a period between December 2018 until June 2020; in Baghdad dermatology center at medical city. One hundred women who were seeking treatment for diffuse hair shedding and who hadn’t received treatment or supplements yet and One hundred fifty control subjects are chosen from patients who were referred to the dermatology clinic for the treatment of nevi and who are not pregnant or lactating, had no systemic or local scalp diseases are included in the study. Full History, physical examination performed for all cases including looking for cutaneous diseases, supplements & drug intake. Serum Vitamin D3 is measured using (Ichroma (TM), Boditech Med Inc., Korea).
 Result: A total of 250 females were included in this study, 100 of them got telogen effluvium & 150 were patients who attend dermatology clinic seeking treatments for nevi or skin tag (control group) .The mean age of cases was (22.59 ±4.837 year) that wasn’t significantly different from mean age of control group (23.647±6.022 years) (p-value =0.127). The mean level of Vitamin D was significantly lower than that of control group (11.16±4.49) Vs (18.98±10.65), P value <0.001. Vitamin D mean level in acute phase was significantly higher than that of chronic phase pts. (11.68±4.77 & 9.93 ±3.55 respectively), p value=0.04. Mean vit. D among symptomatic patients. (9.7 ± 3.5) was significantly lower than that among asymptomatic pts. (13±4.19) (p=0.001).No significant association were noticed between job & residence of the patients of both groups, (P-value =0.283 & 0.069 respectively (.
 Conclusion: Age mean difference was not significant among cases and controls. Deficiency in vitamin D may assume a possible leading cause of telogen effluvium among women with hair loss. Cases were significantly associated with low level of Vitamin D3 than controls.Low level of vitamin D was dominant among housewives, urban women, and among symptomatic patients with acute duration.

Possible Effects of Vitamin D3 and Levofloxacin on Selected Hematology Parameter of Rats

“…Animals treated with Group V showed statistically non-significant reduction in ( WBC) and (elevation in platelets) levels (P>0.05) compared to level in rats with levofloxacin(50mg/kg/day) alone Group II while animals showed non-significant elevation in platelets and reduction WBC (P>0.05) of rats with Group VI compared to Group III and group V had higher platelets and lowest WBC in contrast group VI these results consistent with previous studies (39) (40) .Additionally ، levofloxacin ، which decreased the rats platelet counts during treatment ، may cause mild blood coagulation abnormalities (41) . The thrombocytopenia seen in this study could be caused by either enhanced drugmediated destruction or decreased platelet synthesis as seen in bone marrow suppression (42) ، Given that the rats utilized in this investigation were healthy and had normal blood parameters ، this study concluded that extended treatment of levofloxacin may result in anemia as well as thrombocytopenia (43) (44) .…”

“…In addition ، vitamin D has improved erythropoiesis ، inhibited premature erythrocyte lysis ، prevented polyunsaturated fatty acid oxidation in the erythrocyte membrane ، and increased the amount of erythroid precursor units forming colonies (46) (47) . Levofloxacin has been linked to changes in a variety of blood parameters in rats.…”

“…There are many clinical studies that look at how 1-25(OH)D deficiency affects blood hemoglobin (Hb) levels (14) . Anemia and decreased hemoglobin levels ، according to Patel et al ، are independently linked to 25 hydroxy vitaminD and 1 ، 25 dihydroxy vitaminD deficiency in people with chronic kidney disease (15) . Despite the fact that anemia and vitamin D appear to be related ، the exact mechanism is unknown.…”

Acute Versus Chronic Telogen Hair Loss: A Review of the Knowledge and Recent Facts

“…This can be generalized as getting after a severe illness, nutritional deficiency, drug, emotional stress, infection, or other physiologic trauma. The localized TE seen in inflammatory diseases such as psoriasis and seborrheic dermatitis [4,[19][20][21], as well as post-hair transplantation [22]. Several articles suggested religious headwear and hijab were associated with secondary TE through aggravating underlining seborrheic dermatitis of the scalp [23,24].…”

Knowledge, Attitude, and Practices Related to Vitamin D, Zinc, and Ferritin Deficiencies and the Associated Risk of Hair Loss in Jazan, Saudi Arabia

“…Variations in hair texture can serve as valuable indicators of underlying vitamin deficiencies [ 9 , 10 ]. Consequently, people often inquire about vitamin supplementation as a potential means to prevent or treat dermatological conditions, particularly hair loss [ 10 , 11 ].…”