Ethylenediamine Contact Dermatitis

Provost, Thomas T.; Jillson, Otis F.

doi:10.1001/archderm.1967.01610030009002

Cited by 76 publications

(13 citation statements)

References 6 publications

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“…Widespread dermatitis has also been described after intravenous administration of aminophylline in patients sensitized to ethylenediamine after using an antibiotic cream containing this compound as a stabilizer (Petrozzi & Shore, 1976;Provost & Jillson, 1967).…”

Section: Discussionmentioning

confidence: 99%

Comparative pharmacokinetics of theophylline and aminophylline in man.

Aslaksen¹,

Om²,

T³

1981

Brit J Clinical Pharma

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1 The pharmacokinetics of theophylline and aminophylline was compared after oral administration and intravenous infusion. 2 Theophylline (250 mg) and aminophylline (390 mg) were taken orally by eight healthy volunteers in a randomized cross‐over study. 3 In another cross‐over study theophylline and aminophylline were administered intravenously to six healthy volunteers at a dose corresponding to 5 mg/kg pure theophylline. 4 The protein binding of the theophylline in serum collected during the intravenous study was studied by ultrafiltration. The serum concentration of theophylline was measured by high pressure liquid chromatography. 5 Almost identical concentration‐time curves were found for theophylline and aminophylline in both of the studies. No significant difference was found in the pharmacokinetic parameters or protein binding with the two preparations.

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Section: Discussionmentioning

confidence: 99%

Comparative pharmacokinetics of theophylline and aminophylline in man.

Aslaksen¹,

Om²,

T³

1981

Brit J Clinical Pharma

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“…A prime example of this was seen among troops in World War II who, having previously been sensitised to topical sulphonamide, developed eczematous eruptions after ingestion of oral sulphonamides (9). Systemic contact dermatitis has been wellillustrated in the case of aminophylline which contains ethylenediamine and theophylline; oral challenge with this drug has produced a flare-up of eczema in ethylenediamine-sensitive patients (6). It has also been recorded in patients who were sensitised to topical promethazine to whom oral promethazine was administered (10).…”

Section: Discussionmentioning

confidence: 99%

Oral promethazine hydrochloride in ethylenediamine‐sensitive patients

King

Beck

1983

Contact Dermatitis

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“…Therefore, patients should be advised to avoid systemic use of aminophylline and ethylenediamine-related antihistamines, and also topical exposure to antihistamines derived from ethylenediamine [15,16]. Fortunately, ethylenediamine hydrochloride does not crossreact with the ubiquitous ethylenediamine tetra-acetate (EDTA) [3].…”

Section: The Nitrogen-linked Ethylenediamines and Related Piperazinesmentioning

confidence: 99%

Adverse Cutaneous Reactions of Systemic Antihistamines

Özkaya¹

2005

CMCAIAA

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Cutaneous adverse reactions to systemic antihistamines are rare but an important finding. The reaction may vary from an eczematous eruption as the most frequent type, to rare but severe reactions such as urticaria / angioedema, erythema multiforme / Stevens-Johnson syndrome or Lyell syndrome. This is a review of the reported types of cutaneous adverse reactions due to systemically administered old and new antihistamines.

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Ethylenediamine Contact Dermatitis

Cited by 76 publications

References 6 publications

Comparative pharmacokinetics of theophylline and aminophylline in man.

Comparative pharmacokinetics of theophylline and aminophylline in man.

Oral promethazine hydrochloride in ethylenediamine‐sensitive patients

Adverse Cutaneous Reactions of Systemic Antihistamines

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