Ethylenediamine contact dermatitis

Balato, Nicola; Cusano, Francesco; Lembo, Giuseppe; Ayala, Fabio

doi:10.1111/j.1600-0536.1984.tb00937.x

Cited by 24 publications

(9 citation statements)

References 11 publications

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Letters to Dermatologyeralized and explosive, appearing as urticaria, erythema multiforme or anaphylactic shock [4,5] .In the present study, we report a case of a woman who developed a generalized eczematous reaction in the course of systemic therapy with cetirizine and levocetirizine. Histologic features were characteristic enough to give a relevant diagnostic aid.

Case Report

A 49-year-old woman had a long-standing eczematous foot lesion which she had been self-treating for at least 6 months with topical remedies including a halcinonide-neomycin-amphotericin B ointment containing ethylenediamine as a stabilizer (Anfocort).

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confidence: 89%

Clinicopathologic Features of Systemic Contact Dermatitis from Ethylenediamine in Cetirizine and Levocetirizine

et al. 2006

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Case Report

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confidence: 89%

Clinicopathologic Features of Systemic Contact Dermatitis from Ethylenediamine in Cetirizine and Levocetirizine

et al. 2006

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“…333‐18‐6, is a chemical compound synthesised by reacting ethylenediamine (EDA) with hydrochloric acid or hydrogen chloride gas 1 . Because of its versatility, it has been widely used as chemical intermediate in the production of many industrial compounds and may be found in pharmaceutical products 2 …”

Section: Introductionmentioning

confidence: 99%

Sensitization to ethylenediamine dihydrochloride in patients with contact dermatitis in northeastern Italy from 1996 to 2021

Piapan,

Belloni Fortina,

Giulioni

et al. 2023

Contact Dermatitis

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BackgroundEthylenediamine dihydrochloride is a versatile aliphatic amine found in numerous medications and industrial compounds and is a known sensitiser. The sensitisation prevalence is affected by geographical and socio‐cultural factors.ObjectivesThe objectives are to analyse the temporal trend of sensitisation to ethylenediamine dihydrochloride in northeastern Italy and to investigate associations with occupations.MethodsBetween 1996 and 2021, 30 629 patients with suspected allergic contact dermatitis were patch tested with the Triveneto baseline series. Individual characteristics were collected through a standardised questionnaire.ResultsThe overall prevalence of ethylenediamine dihydrochloride sensitisation was 1.29% with percentages similar in both sexes. We observed a significant decreasing trend over time (p < 0.001), yielding a sensitisation prevalence <1% in recent years. Among departments, residence in Pordenone area was protective for sensitisation. No significant associations were observed with specific occupations. We found significant associations between ethylenediamine dihydrochloride sensitisation and being 26–35 years old (odds ratio [OR], 1.47; 95% confidence interval [CI]: 1.05–2.08), and sensitisation for many haptens, such as paraben mix (OR, 5.3; 95% CI: 3.3–8.5), epoxy resin (OR, 5.1; 95% CI: 3.0–8.7), neomycin sulphate and mercaptobenzothiazole.ConclusionsOur study showed a downward time trend of ethylenediamine dihydrochloride sensitisation in northeastern Italian population and pointed to an update of the Triveneto baseline series.

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“…Ethylenediamine is widely used in industry as a solvent, an additive in some solutions and gels, a corrosion inhibitor, a lubricant, emulsifiers and resin adhesives and for making ethylenediamine derivative (Balato, Cusano, Lembo, & Ayala, 1984). In contrast, it is well-known that most sensitizations are caused by topical preparations containing ethylenediamine as a stabilizer (Angelini, Vena, & Meneghini, 1985).…”

Section: Introductionmentioning

confidence: 99%

Kinetics and Mechanism Study of Oxidation of Ethylenediamine and Ethanolamine by Potassium Ferrate (VI) in Alkaline Media

Chen¹,

Ji²,

Li³

et al. 2018

IJC

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In this work, the kinetics of oxidation of Ethylenediamine and Ethanolamine by Potassium Ferrate (VI) has been studied by using stop –flow spectrometer under alkaline media. The results show that the oxidation-reduction reaction is a first-order to reactant and a negative fraction order to [OH-]. A convincing mechanism involving a slow response as the rate-controlling step is proposed and the rate equations derived from the mechanism was shown to fit all the experimental observations. The rate constants of the rate-controlling step and the thermodynamic activation parameters were calculated.

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Ethylenediamine contact dermatitis

Cited by 24 publications

References 11 publications

Clinicopathologic Features of Systemic Contact Dermatitis from Ethylenediamine in Cetirizine and Levocetirizine

Clinicopathologic Features of Systemic Contact Dermatitis from Ethylenediamine in Cetirizine and Levocetirizine

Sensitization to ethylenediamine dihydrochloride in patients with contact dermatitis in northeastern Italy from 1996 to 2021

Kinetics and Mechanism Study of Oxidation of Ethylenediamine and Ethanolamine by Potassium Ferrate (VI) in Alkaline Media

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