Ethyl α‐Fluoro Silyl Enol Ether: Stereoselective Synthesis and Its Aldol Reaction with Aldehydes and Ketones.

Huang, Xiao‐Ting; Chen, Qing‐Yun

doi:10.1002/chin.200240093

Cited by 1 publication

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“…Therefore, in this investigation, four azetidine-steroid derivatives were synthesized to evaluate their inotropic activity using a heart failure model. The first stage was achieved via preparation of an ether-steroid derivative (figure 1); it is important to mention that there are several methods for the preparation of ether groups which involve a series of reagents such as Me3SiCN, [25] K2CO3/acetone, [26] tetrahydrofuranlithium-aluminum hydride, [27] Me3SiCl, [28] K3PO4-DMF, [29] ethyl cinnamate [30] and others. In this investigation, an ether-steroid derivative (2) was prepared from estrone and p-nitrobenzoyl azide in the presence of dimethyl sulfoxide.…”

Section: Resultsmentioning

confidence: 99%

Design and synthesis of new azetidine‐steroid derivative with inotropic activity in a heart failure model

Figueroa‐Valverde

María

Díaz-Cedillo

et al. 2020

Vietnam Journal of Chemistry

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Several steroid derivatives have prepared as inotropic drugs; however, there are few reports on azetidine‐steroid derivatives with inotropic activity. The aim of this study was to synthesize four azetidine‐steroid derivatives (compounds 3 to 6) to evaluate their biological activity on left ventricular pressure. The first stage was achieved by preparation of azetidine‐derivatives using reactions of etherification and addition. The second stage involves the evaluation of biological activity from azetidine derivatives on left ventricular pressure in a heart failure model using estrone as control. The results showed that only compound 3 increases left ventricular pressure compared with estrone, compounds 2 and 4 to 6. In conclusion, the positive inotropic effect exerted by compound 3 depends on the functional groups involved in their chemical structure.

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