Ethyl 3-acetyl-4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Abstract

Experimental Crystal data C 17 H 20 N 2 O 5 M r = 332.35 Monoclinic, P2 1 =c a = 8.8387 (8) Å b = 20.2043 (18) Å c = 10.0232 (9) Å = 107.839 (2) V = 1703.9 (3) Å 3 Z = 4 Mo K radiation = 0.10 mm À1 T = 293 (2) K 0.3 Â 0.2 Â 0.1 mm Data collectionBruker SMART CCD area-detector diffractometer Absorption correction: none 17507 measured reflections 3343 independent reflections 2369 reflections with I > 2(I) R int = 0.045

Synthesis, Spectroscopic and Crystal Structure Analysis of Two Dihydropyrimidines

“…13,14 A knowledge of the molecular geometry and the probable bioactive structure of a compound is a prerequisite for any understanding of its pharmacological properties. 13,14 A knowledge of the molecular geometry and the probable bioactive structure of a compound is a prerequisite for any understanding of its pharmacological properties.…”

“…The present work is part of our research involving a series of novel dihydropyrimidine derivatives which can be potent mimics of the dihydropyridines. 13,14 A knowledge of the molecular geometry and the probable bioactive structure of a compound is a prerequisite for any understanding of its pharmacological properties. We report here the structures of two dihydropyrimidine derivatives, 1 and 2, both of them potential calcium channel blockers.…”