Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: A comparative assessment

Maheshwari, Rahul; Tekade, Rakesh K.; Sharma, Piyoosh; Darwhekar, G. N.; Tyagi, Abhishek; Patel, Ritesh; Jain, Dinesh Kumar

doi:10.1016/j.jsps.2011.10.001

Cited by 226 publications

(67 citation statements)

References 38 publications

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“…70,87 Table 5 summarizes a review of several drugs reported for transdermal delivery using ELs and recently reported new ELs. [88][89][90][91][92][93][94][95][96][97][98] Furthermore, these latest ELs were tabulated (Table 6) with valuable information, such as definition, composition, classification, advantages, and inherent limitations. 14 …”

Section: Local Anesthetic Drugsmentioning

confidence: 99%

Elastic liposomes as novel carriers: recent advances in drug delivery

Hussain¹,

Singh²,

Sharma

et al. 2017

IJN

138

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Elastic liposomes (EL) are some of the most versatile deformable vesicular carriers that comprise physiologically biocompatible lipids and surfactants for the delivery of numerous challenging molecules and have marked advantages over other colloidal systems. They have been investigated for a wide range of applications in pharmaceutical technology through topical, transdermal, nasal, and oral routes for efficient and effective drug delivery. Increased drug encapsulation efficiency, enhanced drug permeation and penetration into or across the skin, and ultradeformability have led to widespread interest in ELs to modulate drug release, permeation, and drug action more efficiently than conventional drug-release vehicles. This review provides insights into the versatile role that ELs play in the delivery of numerous drugs and biomolecules by improving drug release, permeation, and penetration across the skin as well as stability. Furthermore, it provides future directions that should ensure the widespread use of ELs across all medical fields.

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Section: Local Anesthetic Drugsmentioning

confidence: 99%

Elastic liposomes as novel carriers: recent advances in drug delivery

Hussain¹,

Singh²,

Sharma

et al. 2017

IJN

138

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“…Multilamellar liposomal vesicles were prepared by thin film casting method as reported previously (18), with slight modifications. Briefly, phosphatidylcholine (soya PC) and cholesterol (CH) in 7:3 proportions were dissolved in minimum quantity of chloroform/methanol (3:1; v/v) in round bottom flask (RBF).…”

Section: Preparation Of Liposomes (Lip)mentioning

confidence: 99%

“…In vitro release profile of entrapped drug from different drug-loaded formulations (DTX-LIP, DTX-NP, DTX-DEN, DTX-CNTs) was studied at pH 4 and 7.4 (PBS (pH 7.4 and 4.0): ethanol (7:3) v/v) using dialysis tube diffusion technique (18,32,35). Briefly, drug-loaded formulations were taken into dialysis tubing (MWCO 1-2 kDa, Sigma, India), hermetically sealed from both sides, dipped inside release medium placed on magnetic stirrer (Remi, Mumbai, India) maintained at 37± 0.5°C.…”

Section: Drug Release Studiesmentioning

confidence: 99%

Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential

Mody¹,

Tekade²,

Mehra³

et al. 2014

AAPS PharmSciTech

115

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Abstract. Liposomes (LIP), nanoparticles (NP), dendrimers (DEN), and carbon nanotubes (CNTs), represent eminent classes of drug delivery devices. A study was carried out herewith by employing docetaxel (DTX) as model drug to assess their comparative drug delivery potentials. Under optimized conditions, highest entrapment of DTX was observed in CNT-based formulation (DTX-CNTs, 74.70± 4.9%) followed by nanoparticles (DTX-NP, 62.34±1.5%), liposome (49.2±1.51%), and dendrimers (28.26± 1.74%). All the formulations were found to be of nanometric size. In vitro release studies were carried out in PBS (pH 7.0 and 4.0), wherein all the formulations showed biphasic release pattern. Cytotoxicity assay in human cervical cancer SiHa cells inferred lowest IC 50 value of 1,235.09±41.93 nM with DTX-CNTs, followed by DTX-DEN, DTX-LIP, DTX-NP with IC 50 values of 1,571.22±151.27, 1,653.98±72.89, 1,922.75±75.15 nM, respectively. Plain DTX showed higher hemolytic toxicity of 22.48±0.94%, however loading of DTX inside nanocarriers drastically reduced its hemolytic toxicity (DTX-DEN, 17.22±0.48%; DTX-LIP, 4.13±0.19%; DTX-NP, 6.43±0.44%; DTX-CNTs, 14.87±1.69%).

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“…Ethosomes possess elevated encapsulation competence for a broad range of molecules including lipophilic drugs (Valjakka et al, 1998). Ethosomes bears an influential advantage of successfully delivering the therapeutic agents deeply across the highly conformational and densely packed lipid bilayers of the stratum corneum (SC) by reducing transition temperature (T m ) of SC fluids, increasing their fluidity and by increasing the membrane permeability by the intercalation of polar head group (Maheshwari et al, 2012). Ethosomes provides high patient compliance as they can be formulated in semisolid dosage forms (Gel or Cream) in contrast to complications associated with iontophoresis and phonophoresis (Simonsson et al, 2011).…”

Section: Merits Of Ethosomesmentioning

confidence: 99%

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Pandey¹,

Golhani²,

Shukla³

2014

Drug Delivery

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Delivery across skin is attractive due to its easy accessibility. However, drug delivery across skin is still a challenge in biomedical sciences. Over the past few decades, various successful novel devices and techniques have emerged to optimize drug delivery across skin whose obstructing behavior constricts entry of most of the therapeutic agents. Inability of various conventional vesicular formulations, e.g. liposomes to pass through the tapered (430 nm) intercellular channels of stratum corneum, rendered invention of some lipid based vesicular carrier systems such as ethosomes which consist of phospholipid, ethanol and water. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. In spite of their sophistication in conceptuality, they are exemplified by easiness in their preparation, safety and efficacy -a combination that can highly inflate their application. This review attempts to describe all aspects of ethosomes including roles and upshots of different excipients, various methods of preparation and characterizations, research reports on various drug deliveries, patent reports and future prospects.

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Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: A comparative assessment

Cited by 226 publications

References 38 publications

Elastic liposomes as novel carriers: recent advances in drug delivery

Elastic liposomes as novel carriers: recent advances in drug delivery

Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

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