Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential

Abstract

Abstract. Liposomes (LIP), nanoparticles (NP), dendrimers (DEN), and carbon nanotubes (CNTs), represent eminent classes of drug delivery devices. A study was carried out herewith by employing docetaxel (DTX) as model drug to assess their comparative drug delivery potentials. Under optimized conditions, highest entrapment of DTX was observed in CNT-based formulation (DTX-CNTs, 74.70± 4.9%) followed by nanoparticles (DTX-NP, 62.34±1.5%), liposome (49.2±1.51%), and dendrimers (28.26± 1.74%). All the formulations were found to be of nanometric size. In vitro release studies were carried out in PBS (pH 7.0 and 4.0), wherein all the formulations showed biphasic release pattern. Cytotoxicity assay in human cervical cancer SiHa cells inferred lowest IC 50 value of 1,235.09±41.93 nM with DTX-CNTs, followed by DTX-DEN, DTX-LIP, DTX-NP with IC 50 values of 1,571.22±151.27, 1,653.98±72.89, 1,922.75±75.15 nM, respectively. Plain DTX showed higher hemolytic toxicity of 22.48±0.94%, however loading of DTX inside nanocarriers drastically reduced its hemolytic toxicity (DTX-DEN, 17.22±0.48%; DTX-LIP, 4.13±0.19%; DTX-NP, 6.43±0.44%; DTX-CNTs, 14.87±1.69%).

Nanoways to overcome docetaxel resistance in prostate cancer

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“…Various reports clearly reveal that functionalized CNTs are one of the major tools to target different types of disease, including cancer [19]. In terms of higher drug-loading efficiency, CNTs are proving themselves better carriers compared with other nanocarriers, such as polymeric as well as solid lipid nanoparticles, nanostructured lipid carriers, dendrimers, and liposomes [20]. The SWCNT-doxorubicin (DOX) Carbon nanotube (CNT) toxicity profiles, including their physical attributes, rationale, types, mechanism and level Q12…”

Studies on Enhancement of Anti-microbial Activity of Pristine MWCNTs Against Pathogens

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“…liposomes, nanoparticles, and dendrimers (4). In most of the studies, conducted so far, CNTs have been employed as Bcargo vehicles^to deliver the drug to the desired sites (3,4). The naïve CNTs also possess noticeable antimicrobial action, though the reports are sparse (5).…”

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