Ethnopharmacology of Q’eqchi’ Maya antiepileptic and anxiolytic plants: Effects on the GABAergic system

Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

“…Concentrations (0.001 mg/ml) of whole (Mo) were shown to display modest beneficial effects upon neuronal viability, consistent with our previous studies indicating effects of both oils upon voltagegated sodium channels at low concentrations [18,19,20 and unpublished studies], while at a higher concentration (0.1mg/ml) of (Mo) Fig. 2 and La (not shown) induced a neurotoxicity effect.…”

Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: Sedative effect and chemical analysis of an aqueous extract

“…Thus, it is not surprising to think, that the CNS depressant actions observed with DM administration could be through this important central inhibition system. In agreement with this observation, it is well known that many extracts and plants rich in glycoside and aglycone flavonoids, possess sedative, anxiolytic, and antiepileptic properties mediated through their affinity (in vitro) with benzodiazepine site of GABAergic complex system or are direct or indirect modulators of this receptor (Kahnberg et al, 2002;Fernández et al, 2004Fernández et al, , 2006Fernández et al, , 2009Awad et al, 2009;Estrada-Reyes et al, 2010). Thus the presence of several flavonoids in DM, particularly flavone glycosides, could account for the depressant and sedative effects on the CNS.…”

Organic Extract of Justicia pectoralis Jacq. Leaf Inhibits Interferon-γ Secretion and Has Bacteriostatic Activity against Acinetobacter baumannii and Klebsiella pneumoniae

“…Other studies indicate that aerial parts are also used against nervousness and sleeplessness, as a hypotensive [7, 8], and against epilepsy [9]. However, few authors have described its antineoplastic activity, with most studies about this plant concentrating on its use for treatment of respiratory tract disorders and consequently its anti-inflammatory potential [10].…”