Ethnopharmacological Uses, Phytochemistry, and Pharmacological Properties of <i>Croton macrostachyus</i> Hochst. Ex Delile: A Comprehensive Review

Maroyi, Alfred

doi:10.1155/2017/1694671

Cited by 32 publications

(29 citation statements)

References 70 publications

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“…Some secondary metabolites such as alkaloids, amino acids, anthraquinones, carbohydrates, cardiac glycosides, coumarins, essential oil, fatty acids, flavonoids, phenolic compounds, phlobatannins, polyphenols, phytosteroides, saponins, sterols, tannins, terpenoids, unsaturated sterol, vitamin C, and withanoides were reported in previous studies [24,29].…”

Section: Introductionmentioning

confidence: 81%

“…C. macrostachyus has other claimed medicinal uses in Ethiopia. e bark, fruits, leaves, roots, and seeds of this plant are traditionally used for treatment of diabetes, malaria, stomachache, cancer, ascariasis, abdominal pain, gonorrhea, wounds, ringworm infestation, hemorrhoids, and leishmaniasis [16,[21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…e root extract C. macrostachyus has good in vitro antibacterial (both Gram-negative and Gram-positive bacteria) [25] and antioxidant [20,24] activities. A compound called crotepoxide was isolated from C. macrostachyus which was found to be active against in vitro leishmaniasis [25].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents

Norahun¹,

Atnafie

Atta

2020

Evidence-Based Complementary and Alternative Medicine

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Background. Peptic ulcer disease causes significant mortality and morbidity. Plant kingdom provides a useful source for the development of new antiulcer agents. Croton macrostachyus is traditionally used to treat peptic ulcer in Ethiopia. This study aimed to evaluate the antiulcer activity of C. macrostachyus root extracts in rodents using different models. Methods. The crude extract was obtained by cold maceration in 80% methanol and fractionated with chloroform, ethyl acetate, and distilled water. The antiulcer activity was evaluated using pylorus ligation-induced ulcer model in Sprague Dawley rats and acidified ethanol-induced ulcer model in Swiss albino mice. The test groups received three doses (100, 200, and 400 mg/kg) of the crude extract and fractions for 7 days before induction of ulcer. Positive controls received omeprazole 30 mg/kg for the pylorus ligation-induced ulcer model and sucralfate 100 mg/kg for the acidified ethanol-induced ulcer model. Negative controls received vehicle (2% tween 80). Results. The crude hydromethanolic extract of C. macrostachyus showed significant (p<0.05) antiulcer activity on both pyloric ligation and HCl/ethanol-induced ulcer in rats and mice. It has antisecretary effect (p<0.001) as well. All three administered doses of chloroform fraction (p<0.05) and only higher doses of ethyl acetate fraction (p<0.05) possessed significant antiulcer activity. In contrast, the aqueous fraction did not have significant antiulcer effect at all tested doses. Conclusion. The present study demonstrated that the crude extract, chloroform, and ethyl acetate fractions possessed significant dose-dependent antiulcer activity.

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Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents

Norahun¹,

Atnafie

Atta

2020

Evidence-Based Complementary and Alternative Medicine

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“…Crushed leaves of C. macrostachyus are also boiled in water mixed with Allium sativum and taken orally as a remedy for malaria treatment, in addition to this C. macrostachyus have potent larvicidal activity against the malaria vector An Arabiensis. [28][29][30][31][32][33]…”

Section: Efficacymentioning

confidence: 99%

Phytochemical-constituents, safety and efficacy of commonly used medicinal plants for the treatment of malaria in Ethiopia-a review

Abera¹,

Ashebir²,

Basha³

et al. 2019

PPIJ

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Background: Malaria is among the ten top leading causes of morbidity and mortality in children under-5 years. Due to the rise of drug-resistant parasites and limited therapeutic efficacy of the available drugs, there is a need to search novel antimalarial drugs from medicinal plants commonly utilized as traditional medicines. Traditional medicines are often more available, affordable, sometimes are perceived as more effective than conventional antimalarial drugs, cultural acceptable and the relatively lower cost. Hence traditional medicine becomes the novel candidate for the search and development of drugs for the prevention and treatment of malaria.Objective: The present study aimed to review phytochemical constitute, safety and efficacy commonly used medicinal plants for malaria treatment in Ethiopia. Methods:A web-based literature search was done by using scientific databases including Pub Med, Science Direct, Web of Science and Google Scholar, with inclusion criteria of full length experimental, ethno-botanical and ethno medicinal survey articles reporting on anti-malarial medicinal plants conducted in Ethiopia. Results: The most commonly utilized medicinal plants for the treatment of malaria were Conclusion and recommendation: Aqueous leaf extract of Strychnos mitis possessed a potent chemo suppression of 95.5 % at a dose of 600mg/kg/day. Further chemical isolation, dosage form development, clinical trial, and toxicological study is recommended. Citation: Abera T, Ashebir R, Basha H, et al. Phytochemical-constituents, safety and efficacy of commonly used medicinal plants for the treatment of malaria in Ethiopia-a review.

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“…80 The strain of E. coli are motile because they have flagella arranged in peritrichous, but those lack of flagella are non-motile. 81 E. coli is a catalase positive, oxidase negative, lactose fermenter, coccobacillus gram negative non spore forming rod shaped bacteria. 82 E. coli requires the ability to adapt to variations or extreme changes in temperature, pH, and osmolarity conditions commonly encountered in nature.…”

Section: Study Of Pathogenic Bacteriamentioning

confidence: 99%

Medicinal Value of Croton macrostachyus and Solanum incanum against Causative Agent of Foodborne Diseases

Abdisa¹

2019

Vet Med Open J

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Cite this articleAbdisa T. Medicinal value of Croton Macrostachyus and Solanum Incanum in treatment of foodborne diseases. Vet Med Open ABSTRACT Copyright 2019 by Abdisa T. This is an open-access article distributed under Creative Commons Attribution 4.0 International License (CC BY 4.0), which allows to copy, redistribute, remix, transform, and reproduce in any medium or format, even commercially, provided the original work is properly cited. 57Review | Volume 4 | Issue 2| cc Foodborne diseases are a public health threat which causes a large economic impact across the worldwide. Escherichia coli (E. coli), Listeria monocytogenes (L. monocytogenes), Salmonella species (S. species), Staphylococcus aureus (S. aureus) and many more other organisms are the leading causes of foodborne illness and death in the world. Increment of antibiotic resistance exhibited by the actions of microbial infectious agents has led to screening of several medicinal plants for their potential antimicrobial activity. Therefore, the aim of this paper is to review on the medicinal value of Croton macrostachyus (C. macrostachyus) and Solanum incanum (S. incanum) against causative agents of foodborne disease. Antimicrobial compounds of medicinal plants differ from antibiotics as they have fewer side effects, better patient tolerance, relatively less expensive, acceptance due to a long history of use and being renewable in nature. There are so many medicinal plants used to treat foodborne diseases which associated with gastroenteritis in humans and animals, among plants S. incanum and C. macrostachyus are the common for treatment of foodborne diseases associated with diarrhea. S. incanum has different bioactive substances which have medicinal importance against skin diseases, abdominal pains, fever, stomachaches and indigestion, treatment of dandruff, wounds, sore throat, angina, ear inflammation, liver disorders, wart and ringworm and treatment of cow driosis, dermatophilosis, foot rot, pasteurellosis, black leg, fasciolosis and snake bite. Bioactive compounds which present in S. incanum are including alkaloids, steroids, saponins, tannins, glycosides, flavonoid and terpenoids. C. macrostachyus is medicinal plant which have bioactive compounds including terpenoids, alkaloids, flavonoids, lignoids, proanthcyanidins, sesquiterpenoids and lupeol, saponnins, resins, crotepeoxide. C. macrostachyus have medicinal value in treatment of malaria, rabies, gonorrhea, wound, diarrhea, hepatitis, jaundice, abdominal pain, cancer, toothache, pneumonia, typhoidand gastrointestinal disorder. Which is also used as abortifacient and uterotonic to expel retained placenta. Therefore, S. incanum and C. macrostachyus have different medicinal value against foodborne disease and drug-resistance infectious agents. However, an advanced study have not been conducted on the extract of pure bioactive compounds and toxicity analysis. Therefore, further studies should have to be conducted to extract pure compounds from these medicinal plants for pharmaceutics industry.

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Ethnopharmacological Uses, Phytochemistry, and Pharmacological Properties of Croton macrostachyus Hochst. Ex Delile: A Comprehensive Review

Cited by 32 publications

References 70 publications

Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents

Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents

Phytochemical-constituents, safety and efficacy of commonly used medicinal plants for the treatment of malaria in Ethiopia-a review

Medicinal Value of Croton macrostachyus and Solanum incanum against Causative Agent of Foodborne Diseases

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