Ethnopharmacological studies on antispasmodic and antiplatelet activities of Ficus carica

Antidiarrheal and antispasmodic activities of <i>Adiantum capillus-veneris</i> are predominantly mediated through ATP-dependent K+ channels activation

“…It has been observed that most of the medicinal plants or plant based remedies exhibit inhibitory effect on spontaneously contracting rabbit jejunum through K + channel activation (Gilani et al, 2008;Khan et al, 2011) and/or Ca ++ channel blockade like mechanisms (Shah et al, 2011;Khan et al, 2013;Janbaz et al, 2014). To study the involvement of these inhibitory pathways, low K + (25 mM) and high K + (80 mM) are used to depolarize tissues which distinguish K + channel opening (KCO) and Ca ++ antagonist like mechanisms (Gilani et al, 2008;Janbaz et al, 2014).…”

“…To study the involvement of these inhibitory pathways, low K + (25 mM) and high K + (80 mM) are used to depolarize tissues which distinguish K + channel opening (KCO) and Ca ++ antagonist like mechanisms (Gilani et al, 2008;Janbaz et al, 2014). K + channel openers (increase in K + efflux) and Ca ++ antagonists (inhibition of Ca ++ entry) are known to cause intestinal smooth muscle relaxation by decreasing intracellular free Ca ++ , through respective mechanisms of membrane hyperpolarization, hence such agents are attested for their therapeutic potential in hyperactive gut disorders (Poggioli et al, 1995;Lee et al, 1997).…”

“…For elucidation of the possible mechanism of spasmolytic effect, low K + (25 mM) and high K + (80 mM) were used to depolarize the isolated tissues which in turn produced sustained contractions, which are considered useful for determining the different inhibitory mechanisms like, K + channels activation (Gilani et al, 2008;Khan et al, 2011) or Ca ++ channel blockade (Mehmood et al, 2011;Janbaz et al, 2014), respectively. The test material was then added in a cumulative fashion to obtain concentration-dependent inhibitory response curves.…”

Ficus Carica and Its Constituents Role in Management of Diseases

“…Outcome of the finding showed the presence of spasmolytic activity in the ripe dried fruit possibly mediated through the activation of K+ ATP channels [49].…”

Antidiarrheal and antispasmodic activities of <i>Polygonum bistorta</i> rhizomes are mediated predominantly through K+ channels activation

“…Each tissue was allowed to equilibrate for at least 30 min before the addition of any drug and then stabilized with repeated administration of acetylcholine (Ach, 0.3 µM) at every 3-5 min interval, until similar responses were achieved. Under similar experimental conditions, guinea-pig ileum behaved as quiescent smooth muscle preparation and is considered more useful for the assessment of spasmogenic activity (Mehmood et al, 2011), while rabbit jejunum exhibits spontaneous rhythmic contractions, allowing testing the relaxant (spasmolytic) activity directly without the use of an agonist (Gilani et al, 2008;Khan et al, 2011;Rehman et al, 2013). The relaxant responses were quantified compared to the control spontaneous beating patent of isolated jejunal preparations.…”