Ethnomedicinal uses, phytochemistry and pharmacological study of Ocimum americanum L.: A review

Luanda, Amos; Ripanda, Asha; Sahini, Mtabazi G.; Makangara, John J.

doi:10.1016/j.phyplu.2023.100433

Cited by 9 publications

(8 citation statements)

References 66 publications

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“…[31] These findings highlight the potential of S. viscosa extract in treating various microbial infections, given the abundance of different phytochemicals present in it. Furthermore, the antimicrobial activity of the 80 % ethanolic extract of S. viscosa can be attributed to specific compounds such as Phytol (7) and Cholestanol (13), which have been previously reported to exhibit strong antibacterial and antifungal activity. [44][45]…”

Section: Antimicrobial Screeningmentioning

confidence: 99%

“…Based on GC MS analysis, thirteen compounds from 80 % ethanolic extract of S. viscosa were identified (Table 3). The bioactive compounds were identified based on the molecular weight, peak area, molecular formula, and retention time ( acid ethyl ester (9), ((1R,4aR,4bS,7R,10aR)-1,4a,7-Trimethyl-7vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthren-1yl)methanol (11), [4aS-(4aα,4bβ,7α,8aα)]-7-ethenyl-1,2,3,4,4a,4b,5,6,7,8,8a,9-dodecahydro-1,1,4b,7-tetramethylphenanthrene (12), Cholestanol (13). The structures of the identified compounds are presented in Figure 3.…”

Section: Chemical Profilingmentioning

confidence: 99%

“…[12] According to the WHO, in developing countries, about 80 % of the population still uses traditional drugs made of plant extracts for various purposes particularly for management of medical conditions. [2,13] In these areas, people rely on traditional plant-based remedies to treat common ailments and maintain their well-being. [8] Medicinal plants serve as a valuable resource for the discovery and development of new drugs, many modern pharmaceuticals have been derived from plant compounds or inspired by traditional remedies.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Anbhule

Moyo

Jagadhane

et al. 2023

Chemistry & Biodiversity

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The present study shows the chemical profile, antimicrobial, antiproliferative, and apoptotic effects of Stemodia viscosa extracts. Thirteen bioactive compounds were identified in the 80 % ethanolic extract by GC/MS analysis. The acetone extract exhibited a higher content of flavonoids and phenols of 805.10 μg QE/mg DW and 89.31 μg GAE/mg DW extracts, respectively. Furthermore, the acetone extract possessed the highest antioxidant activity (IC50=9.96 μg/mL). The 80 % ethanolic extract exhibited significant antimicrobial activity; the highest activity was observed against Staphylococcus aureus with a zone of inhibition of 25±0.51 mm, MIC value of 4 mg/mL, and MBC value of 8 mg/mL. The antiproliferative results revealed the presence of anticancer activity with an IC50=91.562 and 74.362 μg/mL against the B16F10 skin and COLO205 colon cancer cells, respectively. The flow cytometric analysis shows that the plant extracts cause cancer cell death through the induction of apoptosis. Our findings confirmed that Stemodia viscosa is a potential source of biologically active compounds.

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Section: Antimicrobial Screeningmentioning

confidence: 99%

Section: Chemical Profilingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Anbhule

Moyo

Jagadhane

et al. 2023

Chemistry & Biodiversity

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“…It is native to the Indian subcontinent and has extensively been utilized in Ayurveda and is frequently referred to as an "Elixir of Life" 21 . The medicinal properties of tulsi led to its use in treating epilepsy 22 , 23 , asthma 24 , cough 25 , anemia 26 , parasite infections 27 , 28 , neuralgia 29 , and inflammation 30 . Tulsi leaf extracts are recommended in the Indian Materia Medica for the treatment of pyrexia, rheumatism, and bronchitis 31 while the tea infusion has been used to treat hepatic and gastrointestinal diseases, the leaf juice has been utilized topically to cure earaches, malaria, snakebites, and mosquito bites 32 .…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver nanoparticle prepared with Ocimum species and assessment of anticancer potential

Alex,

Subburaman,

Chauhan

et al. 2024

Sci Rep

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Silver nanoparticles (AgNPs) have gained much attention due to their unique physical, and chemical properties. Integration of phytochemicals in nanoformulation might have higher applicability in healthcare. Current work demonstrates the synthesis of green AgNPs with O. gratissimum (gr-AgNPs) O. tenuiflorum (te-AgNPs) and O. americanum (am-AgNPs) followed by an evaluation of their antimicrobial and anticancer properties. SEM analysis revealed spherical-shaped particles with average particle sizes of 69.0 ± 5 nm for te-AgNPs, 46.9 ± 9 nm for gr-AgNPs, and 58.5 ± 18.7 nm for am-AgNPs with a polydispersity index below 0.4. The synthesized am-AgNPs effectively inhibited Klebsiella pneumonia, Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Candida albicans with 23 ± 1.58 mm, 20 ± 1.68 mm, 22 ± 1.80 mm, 26 ± 1.85 mm, and 22 ± 1.40 nm of zone of inhibition respectively. Synthesized AgNPs also induced apoptotic cell death in MCF-7 in concentration-dependent manner. IC50 values for am-AgNPs, te-AgNPs, and gr-AgNPs were 14.78 ± 0.89 µg, 18.04 ± 0.63 and 15.41 ± 0.37 µg respectively which suggested that am-AgNPs were the most effective against cancer. At higher dose size (20 µg) AgNPs were equally effective to commercial standard Doxorubicin (DOX). In comparison to te-AgNPs and gr-AgNPs, am-AgNPs have higher in vitro anticancer and antimicrobial effects. The work reported Ocimum americanum for its anticancer properties with chemical profile (GCMS) and compared it with earlier reported species. The activity against microbial pathogens and selected cancer cells clearly depicted that these species have distinct variations in activity. The results have also emphasized on higher potential of biogenic silver nanoparticles in healthcare but before formulation of commercial products, detailed analysis is required with human and animal models.

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“…Over time, there have been several reviews that have studied MAPs, most of which focused on single species and their ethnobotanical uses, phytochemical content, pharmacological activities, cultivation, and propagation [10,[33][34][35][36][37][38][39][40][41][42]. Contrary to that, the present review wants to give a comprehensive overview of the academic studies on MAPs to discover how the expression MAPs has been understood by scholars over time and, more specifically, to realize the weight that socio-economic research regarding MAPs has assumed in this context.…”

Section: Introductionmentioning

confidence: 99%

The Most Relevant Socio-Economic Aspects of Medicinal and Aromatic Plants through a Literature Review

Pergola,

De Falco,

Belliggiano

et al. 2024

Agriculture

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Around the world, medicinal and aromatic plants (MAPs) play a fundamental role in the economic, social, cultural, and ecological ambits of local communities. Today, the most important uses of MAPs are their applications in the pharmaceutical, perfume, cosmetics, toothpaste, soap, beverage, and food industries. At the same time, the expression MAPs is often used with a plurality of meanings that are not always clear and well-defined. Thus, the paper aims to answer two research questions: (1) to understand how the expression MAPs has been meant over time by scholars, and (2) to realize the weight that socio-economic research regarding MAPs has assumed in this context. To these ends, a literature review was conducted using the scientific database Scopus. The results highlight that researchers started talking explicitly about MAPs in the 1950s, and the geographical focus of the literature on this theme is in India, followed by China. Researchers have published studies concerning the agronomic aspects, cultivation, characterization, and germination techniques of MAPs, but the most cited articles concern the health and beneficial properties of their essential oils. At the same time, nobody has ever wondered what MAPs are, and since 1977, the World Health Organization definition has been taken for granted, and any species with medicinal or aromatic functions is considered to be a MAP. Regarding the socio-economic weight of the research conducted on MAPs, they represent only 1% of the total academic publications, but from them, it has emerged that, especially in rural areas, MAPs depict important sources of income for several local communities. At the same time, there is a need to increase the estimation of the ecosystem services that MAPs offer, the analyses of consumer preferences in the search for new business opportunities, and the environmental impact assessment of the entire supply chain.

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Ethnomedicinal uses, phytochemistry and pharmacological study of Ocimum americanum L.: A review

Cited by 9 publications

References 66 publications

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India

Green synthesis of silver nanoparticle prepared with Ocimum species and assessment of anticancer potential

The Most Relevant Socio-Economic Aspects of Medicinal and Aromatic Plants through a Literature Review

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