Ethnobotanical Uses, Phytochemistry and Pharmacological Activities of Peperomia Pellucida (L.) Kunth (Piperaceae)-a Review

Abstract

Peperomia pellucida (L.) Kunth is a herb belonging to the family Piperaceae. In this review, an extensive literature survey was carried out to compile information available on medicinal uses, phytochemistry and pharmacological properties of P. pellucida. The plant is used as food, flavoring agent and as medicine. The plant is used as medicine for treating various ailments or disorders such as asthma, rheumatism, wound, fever, stomach problems, kidney infection, hemorrhoid pain, joint pain, hypertension, diarrhea, snake bite and measles. The plant contains phytochemical groups such as alkaloids, flavonoids, saponins, terpenoids, steroids and glycosides. Compounds such as dill apiole, phytol, stigmasterol, sitosterol, secolignans, tetrahydrofuran lignans, highly methoxylated dihydronaphthalenone, peperomins, sesamin and isoswertisin have been identified in the plant. Studies have shown that the plant exhibited several pharmacological activities such as antimicrobial, antioxidant, anti-angiogenic, antiinflammatory, analgesic, antipyretic, neuropharmacological, antisickling, anticancer, enzyme inhibitory, antiulcer, hypotensive, immunostimulatory, fracture healing and antidiabetic activities which support the traditional use of the plant. Purified chemicals from the plant have also shown to exhibit certain pharmacological activities such as antiulcer, anticancer and antimicrobial activity. By this extensive literature review, it can be concluded that P. pellucida can be utilized as a promising candidate for developing newer drugs with potent pharmacological activities.

Peperomia pellucida (L.) Kunth as an angiotensin-converting enzyme inhibitor in two-kidney, one-clip Goldblatt hypertensive rats

“…This fleshy annual herb belongs to the Piperaceae family. Its common names are pepper elder, shiny bush, rat-ear, and man-to-man, and it is primarily found in tropical areas ( De Fátima Arrigoni-Blank et al, 2004 , Aziba et al, 2001 , Khan et al, 2008 , Raghavendra and Kekuda, 2018 ). The plant has been used traditionally as a diuretic and cholesterol-lowering therapy in the treatment of hypertension and kidney disorders ( De Fátima Arrigoni-Blank et al, 2004 , Aziba et al, 2001 ).…”

“…From a previous study, this plant reported has antipyretic activity ( Khan et al, 2008 ), analgesic activity ( Aziba et al, 2001 ), anti-inflammatory properties ( de Fatima et al, 2004 ), anticancer, antimicrobial, and antioxidant ( Wei et al, 2011 ). The phytochemicals present in the plant include alkaloids, flavonoids, cardiac glycosides, tannins, and anthraquinones ( Aziba et al, 2001 , Xu et al, 2006 , Aqil et al, 1993 , Aqil et al, 1994 , Egwuche et al, 2011 , Raghavendra and Kekuda, 2018 ). Our previous studies illustrated that the methanolic extract of P. pellucida (L.) Kunth inhibited ACE activity in vitro with an IC 50 of 7.17 µg/mL ( Saputri et al, 2015 ).…”

Potensi Teh Herbal Herba Suruhan sebagai Anti- Hipertensi Melalui Aktivitas Penghambatan Angiotensin-Converting Enzyme (ACE)

“…Tumbuhan ini ini merupakan tumbuhan liar yang dapat tumbuh pada permukaan yang keras, teduh, dan lembab, seperti di dinding, batu, parit terjal, serta di pot bunga sebagai gulma [5]. Kandungan kimia dari tumbuhan ini diantaranya alkaloid, flavonoid, saponin, tanin, dan glikosida [6]. Beberapa manfaat herba suruhan selain antihipertensi yaitu sebagai antimikroba, analgesik, anti-inflamasi, antipiretik, antidiabetes, dan antioksidan [7].…”