Ethnobotanical Survey of Antimalarial Plants in Areas of: Abukamola, Angeta, Oculokori and Omarari of Alebtong District in Northern Uganda

Opio, Dickson Robert; Andama, Edward; Kureh, Gbednet Theophilus

doi:10.9734/ejmp/2017/38043

Cited by 15 publications

(12 citation statements)

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“…The compound 23 at a dose of 500 mg/kg showed moderate parasitemia suppression of 52.9% against P. berghei NK 65 in a mouse model [58]. Therefore, E. capensis extracts showed promising antimalarial and antiplasmodial activities and these findings corroborate the traditional usage of bark, leaves, roots, and stem bark as remedies against malaria in Ethiopia [38], Kenya [33][34][35], Nigeria [27], and Uganda [37].…”

Section: Maroyisupporting

confidence: 61%

“…McGaw et al [71] [73]. These antibacterial activities displayed by different extracts of E. capensis somehow confirm the species' antibacterial potential and its usefulness in the treatment and management of bacterial infections such as boils in South Africa [1,41,51,52], diarrhea in Kenya and Uganda [36,37], dysentery in South Africa [25,26], stomach problems in Ethiopia [21,39], and venereal diseases in Kenya and South Africa [25,26,54].…”

Section: Anthelminticmentioning

confidence: 84%

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A Review of the Ethnomedicinal Uses, Phytochemistry and Pharmacological Properties of Ekebergia Capensis Sparrm

Maroyi

2018

Asian J Pharm Clin Res

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Ekebergia capensis is an integral part of indigenous pharmacopeia in tropical Africa. The present study critically reviewed the ethnomedicinal uses, phytochemistry, and pharmacological properties of E. capensis. The keywords including E. capensis, its synonyms, English common names, ethnomedicinal uses, and phytochemistry and pharmacological properties of the species were searched using electronic databases such as ISI web of knowledge, ProQuest, science direct, OATD, Scopus, Open-thesis, PubMed, and Google Scholar. Pre-electronic literature of conference papers, scientific articles, books, book chapters, dissertations, and theses was carried out at the University Library. Literature studies revealed that E. capensis is mainly used as herbal medicine against fever and malaria, gastrointestinal problems, pain, parasitic worms, reproductive problems in women, respiratory problems, and skin diseases. Phytochemical compounds identified from the species include alkaloids, anthraquinones, coumarins, flavonoids, glycoflavonoids, glycosides, iridoids, limonoids, polyphenols, phytosteroids, pregnane, saponins, tannins, and withanolides. Pharmacological studies revealed that E. capensis extracts and compounds have acetylcholinesterase-inhibitory, analgesic and anti-inflammatory, anthelmintic, antibacterial, antifungal, antigonococcal, antimycobacterial, antimycoplasmal, antihypertensive, antioxidant, antimalarial and antiplasmodial, antischistosomal, antitrypanosomal, and antiviral and cytotoxicity activities. Although pharmacological evaluations carried out so far have confirmed the potency of E. capensis crude extracts and compounds, detailed studies are required aimed at establishing the efficacy, clinical relevance, safety, and mechanisms of action of the plant extracts and compounds.

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Section: Maroyisupporting

confidence: 61%

Section: Anthelminticmentioning

confidence: 84%

A Review of the Ethnomedicinal Uses, Phytochemistry and Pharmacological Properties of Ekebergia Capensis Sparrm

Maroyi

2018

Asian J Pharm Clin Res

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“…Treatment of stomachache, cough, fever, skin rush, diabetes [33,42,43], HIV [198], malaria, diarrhea, sickle cell, tuberculosis, pneumonia, colds, ulcers, sore throat, measles, bilharzia, amoebiasis, female sterility, uterine fibroids, and headache [226][227][228][229][230] Anticandidal, antibacterial, and antidiabetic activities [173,[231][232][233] NR: none retrieved in the open literature. 16 Evidence-Based Complementary and Alternative Medicine pounded to produce ointments that are applied topically (10%).…”

Section: Lovoa Trichilioides Harmsmentioning

confidence: 99%

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Omara

Kiprop

Ramkat

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the inventory of plants with reported anticancer activity used in rural Uganda and the evidences supporting their use in cancer therapy. An electronic survey in multidisciplinary databases revealed that 29 plant species belonging to 28 genera distributed among 24 families have been reported to be used in the management of cancer in Uganda. Anticancer plants were majorly from the families Bignoniaceae (7%), Caricaceae (7%), Fabaceae (7%), Moraceae (7%), and Rutaceae (7%). Most species occur in the wild (52%), though some are cultivated (48%). The growth habit of the plants is as trees (55%) or herbs (45%). Anticancer extracts are usually prepared from leaves (29%), bark (24%), roots (21%), and fruits (13%) through decoctions (53%), as food spices (23%) or pounded to produce ointments that are applied topically (10%). Prunus africana (Hook.f.) Kalkman, Opuntia species, Albizia coriaria (Welw. ex Oliver), Daucus carota L., Cyperus alatus (Nees) F. Muell., Markhamia lutea (Benth.) K. Schum., and Oxalis corniculata L. were the most frequently encountered species. As per global reports, Allium sativum L., Annona muricata L., Carica papaya L., Moringa oleifera Lam., Opuntia species, Prunus africana (Hook.f.) Kalkman, and Catharanthus roseus (L.) G. Don. are the most studied species, with the latter having vincristine and vinblastine anticancer drugs developed from it. Prostate, cervical, breast, and skin cancers are the top traditionally treated malignancies. There is a need to isolate and evaluate the anticancer potential of the bioactive compounds in the unstudied claimed plants, such as Cyperus alatus (Nees) F. Muell., Ficus dawei Hutch., Ficus natalensis Hochst., and Lovoa trichilioides Harms, and elucidate their mechanism of anticancer activity.

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“…Katuura et al (2007) studied medicinal plants used for malaria in Mbarara municipality and Rwampara County from where 20 medicinal plants were reported, out of which 19 species were identified with their leaves or roots being used as decoctions or infusions (Table 1), either individually or in combination. Four of the plant species namely, M. indica, T. assiatica, V. amygdalina and V. lasiopus, commonly used for malaria treatment in this Hussein and El-Sebakhy, 1974;Rastrelli et al, 1997;Broussalis et al, 1999;Gadhi et al, 2001;Murillo et al, 2001;Wu et al, 2002;Hamill et al, 2000;Shi et al, 2004;Belay, 2011;Stangeland et al, 2011;Jimenez-Arellanes et al, 2012;Zamilpa et al, Tidjani et al, 1989;Stone, 1992;Hamill et al, 2000;Tabuti 2008;Ghimeray et al, 2009;Mbaya et al, 2010;Stangeland et al, 2011;Ashafa et al, 2012;Wang et al, 2013;Adia et al, 2014;Jamra et al, 2014;Mahilrajan et al, 2014;Prashanth and Krishnaiah, 2014;Yan et al, 2015;Kamatenesi et al, 2011;Anywar et al, 2016;Anand et al, 2016;Opio et al, 2017;Philip et al, 2017;Sinha et al, 2017 Bidens pilosa L. Geissberger and Séquin, 1991;…”

Section: Resultsmentioning

confidence: 99%

“…stapf (Poaceae) Vinitketkumnuen et al, 1994;Viana et al, 2000;Sacchetti et al, 2005;Adeneye and Agbaje. 2007;Fandohan et al, 2008;Silva et al, 2008;Blanco et al, 2009;Pereira et al, 2009;Figueirinha et al, 2010;Olivero-Verbel et al, 2010;Bassolé et al, 2011;Stangeland et al, 2011;Machado et al, 2012;Francisco et al, 2013;Gbenou et al, 2013;Ukpai and Amaechi, 2012;Bao et al, Adia et al, 2014;Ekpeyong et al, 2015;Sagradas et al, 2015;Chukwuocha et al, 2016;De Silva et al, 2017;Philip et al, 2017;Venzon et al, 2018 Hoslundia Weenen et al, 1990;Achenbach et al, 1992;Gundidza et al, 1992;Mujovo et al, 2008;Usman et al, 2010;Gathirwa et al, 2011;Lacroix et al, 2011;Stangeland et al, 2011;Salame et al, 2012;Asiimwe et al, 2013;Adia et al, 2014;Babarinde et al, 2014;Kamatenesi et al, 2011;Anywar et al, 2016;Opio et al, 2017…”

Section: Resultsunclassified

A review for selecting medicinal plants commonly used for malaria in Uganda

Ajayi¹,

Elujoba²,

Kasali³

et al. 2020

Afr. J. Pharm. Pharmacol.

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Ethnobotanical Survey of Antimalarial Plants in Areas of: Abukamola, Angeta, Oculokori and Omarari of Alebtong District in Northern Uganda

Cited by 15 publications

References 0 publications

A Review of the Ethnomedicinal Uses, Phytochemistry and Pharmacological Properties of Ekebergia Capensis Sparrm

A Review of the Ethnomedicinal Uses, Phytochemistry and Pharmacological Properties of Ekebergia Capensis Sparrm

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

A review for selecting medicinal plants commonly used for malaria in Uganda

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