Ethnobotanical study of plants used against malaria in Sélingué subdistrict, Mali

Diarra, Nouhoum; Klooster, Charlotte van’t; Togola, Adiaratou; Diallo, Drissa; Willcox, Merlin; Jong, Joop de

doi:10.1016/j.jep.2015.02.054

Cited by 64 publications

(39 citation statements)

References 28 publications

(26 reference statements)

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“…It is a threat to approximately 3.4 billion people in about 209 countries and territories (Diarra et al 2015). In 2012, there were an estimated 207 million cases of malaria with over 627.000 deaths (World Health Organization 2014).…”

Section: Introductionmentioning

confidence: 99%

A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

Nyemeck

Bikobo

Zintchem

et al. 2017

Natural Product Research

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Phytochemical investigation of the stem bark of Campylospermum zenkeri led to the isolation of five known compounds: (Z,Z)-9,12-octadecadienoic acid (1), serotobenine (2), agathisflavone (3), lophirone A (4) and lophirone F (5), together with a new derivative of procyanidin B, a catechin dimer named zenkerinol (6). Serotobenine (2) is structurally related to decursivine which shows moderate activity against D6 and W2 strains of Plasmodium falciparum. For a better understanding of structure-activity relationships, three new semisynthetic derivatives of serotobenine (2) have been prepared. These are: serotobenine monopropionate (2a), serotobenine monopivalate (2b) and serotobenine cyclohexyl ether (2c) respectively. Two of them (2a) and (2b), were evaluated for their antiplasmodial activity against P. falciparum 3D7 strain in a parasite lactate-dehydrogenase (pLDH) assay. Compound 2b was more active than compound 2a based on their IC 50 values (36.6 and 123 μM, respectively).

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Section: Introductionmentioning

confidence: 99%

A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

Nyemeck

Bikobo

Zintchem

et al. 2017

Natural Product Research

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“…Furthermore, some of them are used in traditional medicine to treat malaria and fever (TABUTI, 2008;TRAORE et al, 2013;DIARRA et al, 2015; AGBOEKA e al., 2016). The activity of our methanolic extract (IC 50 = 5.89 μg/mL) was similar to that presented by C. molle methanolic extract (IC 50 = 5.7 μg/mL), which was extracted from its leaves.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Antiplasmodial Activity of Flower Extracts From Combretum Leprosum Mart (Mofumbo)

Passarini

Medeiros

Meneguetti

et al. 2016

CeN

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Malaria is the cause of hundreds of thousands of deaths per year, besides putting billions of people at risk of developing disease. When it comes to its therapy, the drugs used currently are losing its efficacy due to increase in the frequency of resistant strains of the parasite, highlighting the importance for the search of new classes of molecules presenting antiplasmodial activity. In the present work, the antiplasmodial activities of five extracts (crude, hexane, chloroform, ethyl acetate and methanol) from the flowers of Combretum leprosum are assessed. The method employed for obtaining the extracts was silica gel column chromatography, and the techniques used for the analysis of antiplasmodial activity (IC 50 ) and citotoxicity (MLD 50 ) were ELISA and MTT respectively, where a selectivity index was calculated after the obtaining of these two values. The extract presenting the highest antiplasmodial activity was the chloroform extract (IC 50 = 3.97 µg/mL), however, this extract also presented the higher cytotoxicity (MLD 50 = 18.12 µg/mL), and therefore the extract presenting the best overall activity was the methanolic extract (IS = 18.97 IntrodutionOver 3 billion people are estimated to be at risk of being infected with malaria and therefore developing disease, and according to latest estimates, hundreds of thousands of deaths caused by it occurred in each year of this millennium (WHO, 2014). The world region that suffers the heaviest burden is Africa, where the great majority of cases of malaria occur, mainly in children under the age of five (WHO, 2014). The disease is caused by parasitic protozoa of the genus Plasmodium, of which five species are known to infect humans: P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi (COX, 2010). The parasite life cycle begins when a female mosquito of Anopheles genus bites a human and releases the sporozoites from its salivary glands to the dermis, where they reach the avascular tissue and then a percentage of them migrates and enters the blood vessels, making their way to the liver, where they undergo cellular modifications and perform rounds of asexual replication (ALY; VAUGHAN; KAPPE, 2009).After leaving the liver, the parasite begins other cycles of asexual replication inside red blood cells, using molecules and cellular structures of the host cells to survive, grow and reproduce, generating thousands of merozoites and causing the characteristic symptoms of the disease (TILLEY; DIXON; KIRK, 2011). When it comes to its chemotherapy, most of the cases of uncomplicated malaria are treated currently by the use of ACT's drugs, although is already known that these drugs are losing its efficacy due to the increase in frequency of resistant strains (VISSER; VUGT; GROBUSCH, 2014), which highlights the importance for the search of new molecules bearing antiplasmodial activity.Plants have been used during millennia by humanity, and pharmacological studies of medicinal plants yielded useful molecules in the treatment of various diseases, includ...

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“…It is reported that it is used to treat dysentery and/or diarrhea [4,7,[9][10][11][12][13][14]. Many authors reported that G.snenegalensis used in traditional medicine to treat Malaria and /or fever [5,7,11,[14][15][16][17][18][19][20][21][22]. It is also reported as antileprosy [4,5,7,11,17,21], Abdominal pains [4,7,9,10], Epilepsy [7], depressant [23], cough and/or cold, [4,7,15,24,25], snakebite [11,26], Eczema [7], syphilis [5], hypertension and hypotension [11,24,25], diabetes [11,17], Impotence [5,7] , Breast cancer and Jaundice …”

Section: Traditional Medicine Usesmentioning

confidence: 99%

A Review on the Taxonomy, Ethnobotany, Phytochemistry and Pharmacology of Guriea senegalensis J.F.Gmel. (Combretaceae)

Hamad¹,

Elsafi²,

Saeed³

et al. 2017

Med Aromat Plants

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Guiera senegalesis (G. senegalensis) Family Combretaceae is shrubs or trees widely distributed in west and central Africa. In traditional medicine G. senegalensis used to treat malaria, dysentery and/or diarrhea, cough and/ cold, abdominal pains, leprosy, hypotension and hypertension, diabetes, snakebites eczema, impotence, epilepsy, breast cancer, depressant and jaundice. Phytochemical screening investigated by scientists showed the presence of alkaloids, flavonoids, tannin, saponin, terpinoids/sterols and cardionolics mainly in leaves and roots of the plant. The biological activities showed positive results as anti-tuberculosis, anti-diarrhoeal, anti-plasmodia, analgesic and devoid of anti-inflammatory, antifungal, antioxidant anti-lipid peroxidation activity, anti-malaria and with low toxicity, antifungal, anti-acetylcholinesterase, antilipid peroxidation in rat's brain homogenate, erythrocytes hemolysis inhibitory activities and antitussive activities. The review revealed the importance of G. senegalensis as a natural therapy and recommend for further study and the work of the pharmaceutical formulation.

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Ethnobotanical study of plants used against malaria in Sélingué subdistrict, Mali

Cited by 64 publications

References 28 publications

A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

In Vitro Antiplasmodial Activity of Flower Extracts From Combretum Leprosum Mart (Mofumbo)

A Review on the Taxonomy, Ethnobotany, Phytochemistry and Pharmacology of Guriea senegalensis J.F.Gmel. (Combretaceae)

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