A new procyanidin B from <i>Campylospermum zenkeri</i> (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

Nyemeck, Norbert Mbabi; Bikobo, Dominique Serge Ngono; Zintchem, Auguste Abouem A; Schäfer, Eva M; Bochet, Christian G.; Pegnyemb, Dieudonné Emmanuel; Koert, Ulrich

doi:10.1080/14786419.2017.1305378

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…The ECD spectrum is shown in Figure 1. Similar structures have previously been reported from various Ochna, 27,31,32 Campylospermum, 22,33 and Lophira 34,35 of −21 (c 0.013, CH 3 OH). IR vibrations at 3382 and 1604 cm −1 suggested the presence of hydroxy and CC groups, respectively.…”

Section: ■ Results and Discussionsupporting

confidence: 86%

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Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii

et al. 2021

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Two new biflavanones ( 1 and 2 ), three new bichalconoids ( 3 – 5 ), and 11 known flavonoid analogues ( 6 – 16 ) were isolated from the stem bark extract (CH 3 OH–CH 2 Cl 2 , 7:3, v/v) of Ochna holstii . The structures of the isolated metabolites were elucidated by NMR spectroscopic and mass spectrometric analyses. The crude extract and the isolated metabolites were evaluated for antibacterial activity against Bacillus subtilis (Gram-positive) and Escherichia coli (Gram-negative) as well as for cytotoxicity against the MCF-7 human breast cancer cell line. The crude extract and holstiinone A ( 1 ) exhibited moderate antibacterial activity against B. subtilis with MIC values of 9.1 μg/mL and 14 μM, respectively. The crude extract and lophirone F ( 14 ) showed cytotoxicity against MCF-7 with EC 50 values of 11 μg/mL and 24 μM, respectively. The other isolated metabolites showed no significant antibacterial activities (MIC > 250 μM) and cytotoxicities (EC 50 ≥ 350 μM).

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Section: ■ Results and Discussionsupporting

confidence: 86%

“…The ECD spectrum is shown in Figure . Similar structures have previously been reported from various Ochna , ,, Campylospermum , , and Lophira , species, however without their absolute configuration having been determined.…”

Section: Resultssupporting

confidence: 81%

Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii

et al. 2021

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“…On the other hand, among the neglected diseases, leishmaniasis and mosquito-derived diseases are two major consequences in the tropical regions of the world. Agathisflavone has been found to act against a number of viruses (10,30) and such kinds of parasities (14,31).…”

Section: Discussionmentioning

confidence: 99%

“…Agathisflavone was found to inhibit recombinant cathepsin L in Leishmania mexicana (IC 50 values ranging from 0.43 AE 0.04 μM) (31). Moreover, it is also evident to act against Plasmodium falciparum (14).…”

Section: Antiparasitic Activitymentioning

confidence: 99%

Agathisflavone: Botanical sources, therapeutic promises, and molecular docking study

et al. 2019

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In this article, we have summarized the biological sources and pharmacological activities of agathisflavone along with molecular docking studies to correlate the interaction of this biflavonoid and biomacromolecules involving in its biological effects observed in database‐oriented scientific reports. For this, an up‐to‐date (from 1991 to October 2018) search was done on the databases such as PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society, http://clinicaltrials.gov, and Google Scholar databases. The findings suggest that agathisflavone possesses antioxidant, anti‐inflammatory, antiviral, antiparasitic, cytotoxic, neuroprotective, and hepatoprotective activities. An in silico study of agathisflavone against 17 essential proteins/enzymes revealed that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)‐2 are the most efficient enzymes for the interaction and binding of this biflavonoid for its anti‐inflammatory activity. In conclusion, agathisflavone may be one of the promising plant‐derived lead compounds in the treatment of oxidative stress, inflammatory diseases, microbial infection, hepatic and neurological diseases and disorders, and cancer. © 2019 IUBMB Life, 71(9):1192–1200, 2019

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“…Moschamindole (MCD), a rare phenolic amide with 8/6/6/5/5 rings, is a major bioactive constituent derived from a traditional Chinese medicine Phragmites communis Trin (Poaceae) that is widely prescribed to treat fever and atrophic lung disease in Chinese clinics (Nikaido, Sung, Ohmoto, & Sankawa, 1984;Tsitsa-Tzardi, Skaltsa-Diamantidis, Philianos, & Delitheos, 1990). Pharmacological screening shows that MCD possesses various activities, including antimalarial (Mbabi Nyemeck et al, 2017), cytotoxicity, antimicrobial (Abouem a Zintchem et al, 2008), antioxidant, antibacterial, and anti-AChE (acetyl cholinesterase) activities (Peng et al, 2017), prompting its synthesis by many chemists. However, the antitumour activity of MCD has not yet been investigated in GBM cells.…”

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confidence: 99%

Moschamindole induces glioma cell apoptosis by blocking Mia40‐dependent mitochondrial intermembrane space assembly and oxidative respiration

Huang

Chen

Yang

et al. 2021

Phytotherapy Research

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Glioblastoma multiforme (GBM) is the most frequent, lethal, and aggressive tumor of the central nervous system in adults. In this study, we found for the first time that moschamindole (MCD), a rare phenolic amide with 8/6/6/5/5 rings, is a major bioactive constituent derived from Phragmites communis Trin (Poaceae) that exhibits a potential cytotoxic effect on both TMZ-resistant GBM cell lines and xenograft models. MCD-induced intrinsic apoptosis signals and mitochondrial dysfunction were confirmed by cell cycle arrest, caspase-3/7 activation, and membrane potential depolarization. Furthermore, investigations exploring the mechanism showed that MCD specifically inhibits Mia40-mediated oxidative folding of mitochondrial intermembrane space (IMS) proteins via PCR assay and immunoblot analysis. MCD relies on its positive charge to associate with mitochondrial oxidative respiration, thus blocking energy metabolism and inducing apoptosis. Overexpression and upregulation of Mia40 were proven to reverse MCD-induced apoptosis and were correlated with the chemoresistance of GBM in vitro and in vivo, respectively. Taken together, our study demonstrates that Mia40 is a potential target of the chemoresistance of glioblastoma and suggests that MCD might be a potential agent for the individualized treatment of chemoresistant GBM based on mitochondrial metabolic characteristics and Mia40 expression.

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A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine

Cited by 7 publications

References 34 publications

Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii

Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii

Agathisflavone: Botanical sources, therapeutic promises, and molecular docking study

Moschamindole induces glioma cell apoptosis by blocking Mia40‐dependent mitochondrial intermembrane space assembly and oxidative respiration

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