Ethnicity-related differences in left ventricular function, structure and geometry: a population study of UK Indian Asian and European white subjects

Abstract

Compared to European white people, Indian Asians had attenuated longitudinal LV function, higher LV filling pressure and demonstrated a greater degree of concentric remodelling independent of other demographic and clinical parameters.

Impact of Prehypertension on Left Ventricular Structure, Function and Geometry

“…Such mechanisms involved, were probably due to increased sympathetic activity (norepinephrine release) and involvement of rennin-angiotensin-aldosterone system [25]. Balci et al, [30] observed the similar results related to systolic function in essential hypertension.…”

“…an increased HR, SV, CO, and CI, including TPR [25]. In hypertension, reduced CO is mainly the result of LV diastolic dysfunction in the course of LVH and decreased beta-receptor reactivity in the mode of "down-regulation".…”

Indian Asians have poorer cardiovascular autonomic function than Europeans: this is due to greater hyperglycaemia and may contribute to their greater risk of heart disease

“…The presence of CHD, heart attack or angina, diabetes and hypertension were established on the basis of questionnaire self-report of a doctor's diagnosis. As these conditions had been tested for in LOLIPOP [10], including ECG, blood pressure and fasting blood glucose measurements, it is likely that much previously undiagnosed disease had already been detected, reducing the chance of inter-ethnic biases in detection rates. Ethnicity was confirmed with the participant, based on selfassessment and place of birth of all four grandparents.…”

“…Study of clinic populations, or studies excluding individuals on the basis of treatments or disease may result in a sample that is biased by ethnicity (as clinic attendance, disease and treatment vary markedly by ethnicity), making the findings uninterpretable. We therefore recruited from the London Life Science Prospective Population Study (LOLIPOP), a West London multi-ethnic, population-based study of more than 25,000 individuals investigating chronic disease and its determinants [10]. Men (aged 35-75 years) and women (aged 55-75 years) were recruited to LOLIPOP from 58 primary care lists.…”

Comparative study of Left Ventricular Mass Index (LVMI) between Prehypertensives and Normotensives.

“…an increased heart rate( HR),stroke volume( SV),cardiac output(CO), and including Total Peripheral Resistant( TPR) 11 .…”