Ethnic origin of y-chromosome haplotypes in subpopulations located at different altitudes in northwest Argentina

Dipierri, José Edgardo; Alfaro, Emma; Martínez, Verónica L.; Bailliet, Graciela; Bravi, Cláudio M.; Bianchi, Néstor O.

doi:10.22199/s07181043.1998.0015.00012

Cited by 45 publications

(66 citation statements)

References 14 publications

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“…In a previous report [23], we correlated the origin of surnames with the origin of Y-specific haplotypes, having observed a disagreement between the expected and the observed results in 15% of cases, a similar figure to that detected in the present report in which Y3 and Y4 haplotypes represent 4/13 of the individuals analyzed. However, the use of surnames as a Y-linked marker cannot be applied to isolated, inbred populations such as Aicuña, which probably represents the situation of most rural Latin American communities, where illegitimacy has been very common in the past, leading to the matrilineal transmission of surnames.…”

Section: On the Use Of Surnamessupporting

confidence: 82%

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Correlation between Molecular and Conventional Genealogies in Aicuña: A Rural Population from Northwestern Argentina

et al. 2001

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Aicuña is a village in the northwest of Argentina, located about 300 km south of La Rioja city, in the province of La Rioja. The population of Aicuña derives from a founder couple established in the uninhabited Aicuña valley in the early years of the 17th century. Due to land ownership litigation, the descendants maintained a well-documented genealogy that extends for 12 generations, comprising more than 8,000 individuals. From the historical pedigree of Aicuña, we selected 14 males with direct patrilineal descent from the 2 most ancient male founders, and 23 donors (9 females and 14 males) with direct matrilineal descent from the most ancient female founder. All 3 founders lived in the 17th century. We collected DNA from buccal swabs and characterized the mitochondrial DNA (mtDNA) and Y haplotypes using 14 Y-specific markers, 11 mtDNA polymorphic markers and sequencing of the mt hypervariable regions 1 and 2. We found four different Y haplotypes: Y1 and Y2 haplotypes of European origin corresponding to the founder ancestors Francisco Páez de Espinoza and Apolinario Ormeño, which were shared by 6 and 3 donors, respectively. Three males selected as Ormeño patrilineal descendants showed a different Y haplotype (Y3), probably originated by erroneous paternity registration due to illegitimacy. The remaining case (haplotype Y4), also assumed to belong to the Ormeño lineage, was probably also due to an erroneously registered paternity. Twenty-two donors showed an association of mtDNA markers corresponding to the Amerindian haplotype A2. The founder of this matrilineage could be traced back for more than 14 generations. The haplotype B of one remaining female did not correspond with the historical pedigree and could be due to an error in the genealogy registration. Our results showed an 85% agreement between conventional and molecular genealogies, with mtDNA markers being Amerindian, and Y markers being European. The methodology used in this report is a tool which could potentially be employed as a precedent for land ownership by Aicuña villagers and Amerindian populations.

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Section: On the Use Of Surnamessupporting

confidence: 82%

“…Lately, however, several informative polymorphisms have been reported allowing the reconstruction of the evolutionary history of modern humans [13][14][15], the early colonization events of Europe [15,16], America [17][18][19][20] and Polynesia [21], and enabling us to ascertain the pattern of gene admixture of human populations [22][23][24].…”

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Correlation between Molecular and Conventional Genealogies in Aicuña: A Rural Population from Northwestern Argentina

et al. 2001

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“…For instance, Dipierri et al (1998) show that the Native American component in two northwestern Argentinean populations is *65%, the introgression being more evident on the Y-chromosome side with frequencies of *28% in Quebrada de Humahuaca and *64% in San Salvador de Jujuy. On the other hand, the population of La Plata (Argentina) shows a Native American component of *46% and a paternal contribution of *11% (Martinez-Marignac et al 2004).…”

Section: Final Remarksmentioning

confidence: 99%

Gender bias in the multiethnic genetic composition of central Argentina

et al. 2008

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“…Finalmente, de acuerdo con los resultados de este estudio, y de otros antecedentes reportados en la literatura (38, [41][42][43][44], debe utilizarse con cautela el apellido como marcador de población (20)(21)(22)(23)(24)(25)(26) por cuanto, tal y como pudimos demostrar en la región suroccidental, cerca de 40% de los individuos que refirieron apellido de origen europeo tienen un cromosoma Y compatible con un linaje amerindio, y cerca de 40% de los individuos que refirieron apellido de origen amerindio, tienen un cromosoma Y compatible con un linaje europeo. La proporción amerindio/europeo debe definirse adecuadamente en los estudios que utilicen la isonimia en cualquier región de Colombia, bien sea en estudios clínicos o genéticos, con el fin de afinar el genérico de mestizos a la luz de las herramientas moleculares disponibles hoy.…”

Section: Discussionunclassified

De genotipos e isonimias: análisis de correlación entre el apellido y el patrimonio genético heredado en el cromosoma Y en la población de tres departamentos del suroccidente colombiano

Gómez¹,

Avila²,

Briceño³

2008

biomedica

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Introducción. Es bien sabido que, entre los caracteres transmitidos por la línea paterna, el apellido se ha configurado en diferentes culturas como un carácter semejante a un alelo genético neutral asociado al cromosoma Y.Objetivo. En este estudio se determinaron las frecuencias en la población de 17 STR del cromosoma Y en 308 individuos provenientes de las poblaciones de los departamentos del Valle del Cauca, Cauca y Nariño. Además, se propuso definir la correlación de los haplotipos obtenidos en cada individuo con su apellido paterno, para comparar estos dos códigos de identidad. Materiales y métodos. Se extrajo el ADN de cada individuo a partir de sangre periférica y se utilizó el estuche comercial AmpFLSTR ® Yfiler™ (Applied Biosystems) para tipificarlo. Los resultados de los haplotipos moleculares se compararon con los apellidos reportados por cada individuo y se asociaron apellidos amerindios y europeos con haplotipos que incluyeran o no el marcador DYS19/13, característico de la población amerindia. Resultados. Se reportan las frecuencias alélicas de cada uno de los 17 marcadores del cromosoma Y analizados en esta región de Colombia, así como la diversidad génica y haplotípica hallada en los tres departamentos. Al comparar los resultados obtenidos a nivel molecular con los apellidos de origen europeo o amerindio reportados por cada uno de los individuos, se encontró cerca de 40% de inconsistencia de linaje. Conclusiones. La utilización del apellido como marcador de población debe hacerse con cautela, por cuanto las genealogías fundamentadas en éstos pueden no corresponder al origen biológico de sus portadores.Palabras clave: genotipo, nombres, cromosoma Y, indios sudamericanos, Colombia. Correlation analysis of surnames and Y-chromosome genetic heritage in 3 provinces of southwestern ColombiaIntroduction. In Colombia, surnames are characters usually passed to the children by the father, and they have been compared to neutral alleles associated with the Y-chromosome. Objective. Population frequencies were determined for 17 short tandem repeats (STR) DNA markers on the Y-chromosome to compare the two identity codes and define the correlation between haplotypes and surnames in each individual. Materials and methods. DNA was extracted from blood samples from 308 male individuals in provinces of Valle del Cauca, Cauca and Nariño, all in southwestern Colombia. Sample DNA was analyzed with the commercial kit AmpFLSTR ® Yfiler™ (Applied Biosystems) and examined for the following 17 Y-chromosome STR markers: DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a/b, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635 and Y-GATA-H4. The frequencies of molecular haplotypes were associated with the surname reported by each individual, and a correlation Amerindian and European surnames were associated with the presence of allele DYS19/13, a characteristic of Amerindian populations. Results. Allele frequencies were reported for each of the 17 STR markers in the southwestern region of Colombia-high genetic ...

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Ethnic origin of y-chromosome haplotypes in subpopulations located at different altitudes in northwest Argentina

Cited by 45 publications

References 14 publications

Correlation between Molecular and Conventional Genealogies in Aicuña: A Rural Population from Northwestern Argentina

Correlation between Molecular and Conventional Genealogies in Aicuña: A Rural Population from Northwestern Argentina

Gender bias in the multiethnic genetic composition of central Argentina

De genotipos e isonimias: análisis de correlación entre el apellido y el patrimonio genético heredado en el cromosoma Y en la población de tres departamentos del suroccidente colombiano

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