Ethnic differences in the lifestyle behaviors and premature coronary artery disease: a multi-center study

Abstract

Background Diverse ethnic groups that exist in Iran may differ regarding the risk factors such as hypertension, hyperlipidemia, dyslipidemia, diabetes mellitus, and family history of non-communicable disease. Premature Coronary Artery Disease (PCAD) is more endemic in Iran than before. This study sought to assess the association between ethnicity and lifestyle behaviors in eight major Iranian ethnic groups with PCAD. Methods In this study, 2863 patients aged ≤ 70 for women and ≤ 60 for men who underwent coronary angiography were recruited in a multi-center framework. All the patients’ demographic, laboratory, clinical, and risk factor data were retrieved. Eight large ethnicities in Iran, including the Farses, the Kurds, the Turks, the Gilaks, the Arabs, the Lors, the Qashqai, and the Bakhtiari were evaluated for PCAD. Different lifestyle components and having PCAD were compared among the ethnical groups using multivariable modeling. Results The mean age of the 2863 patients participated was 55.66 ± 7.70 years. The Fars ethnicity with 1654 people, was the most subject in this study. Family history of more than three chronic diseases (1279 (44.7%) was the most common risk factor. The Turk ethnic group had the highest prevalence of ≥ 3 simultaneous lifestyle-related risk factors (24.3%), and the Bakhtiari ethnic group had the highest prevalence of no lifestyle-related risk factors (20.9%). Adjusted models showed that having all three abnormal lifestyle components increased the risk of PCAD (OR = 2.28, 95% CI: 1.04–1.06). The Arabs had the most chance of getting PCAD among other ethnicities (OR = 2.26, 95%CI: 1.40–3.65). While, the Kurds with a healthy lifestyle showed the lowest chance of getting PCAD (OR = 1.96, 95%CI: 1.05–3.67)). Conclusions This study found there was heterogeneity in having PACD and a diverse distribution in its well-known traditional lifestyle-related risk factors among major Iranian ethnic groups.

Association of rs5051 and rs699 polymorphisms in angiotensinogen with coronary artery disease in Iranian population: A case-control study

“…[ 23 ] Previously, heterogeneity in CAD severity in the Iranian population was associated with an increased risk in Gilak and Turks. [ 24 , 25 ] Here, we compared the frequency of CAD in the Iranian North population, which includes three major groups: Fars, Turkmen, and Sistani. Our observations did not indicate a significant association between CAD and ethnicity.…”

Associations of ECG Signs of Ischemic and Non-Specific Signs of Metabolic Changes in the Myocardium With Unfavorable Cardiovascular Prognosis in a 7-Year Prospective Follow-Up of Young People Under 45 Years

“…Сердечно-сосудистые заболевания (ССЗ) остаются на первой позиции причин смертности и инвалидизации населения трудоспособного возраста в мире и в России. Из-вестна тенденция к увеличению распространенности ССЗ и их факторов риска среди населения молодого возраста [1][2][3][4][5].…”

Coronary artery disease incidence, risk factors, awareness, and medication utilization in a 10-year cohort study

“…Globally, cardiovascular disease (CVD) is the leading cause of disability and premature death [ 1 ]. Coronary artery disease (CAD) emerges as the predominant form of CVD [ 2 ]. According to the global burden of disease (GBD) data, CAD was responsible for 16.2% of all-cause deaths and 7.19% of disability-adjusted life years (DALY) worldwide in 2019 [ 3 ].…”

“…However, these risk factors were not evaluated for their impact on CAD incidence. Although there have been several attempts to compile the burden of CAD in Iran in the past [ 2 , 5 , 10 – 12 ], there is no comprehensive analysis available that compares risk factors, their attributable risk, self-awareness of people about them, and medications use for risk factors in a single framework.…”