Ethnic differences in metabolic cardiovascular risk among normal weight individuals: Implications for cardiovascular risk screening. The HELIUS study

Perini, Wilco; Kunst, Anton E.; Snijder, Marieke B.; Peters, Ron J.G.; Valkengoed, Irene G. M. van

doi:10.1016/j.numecd.2018.09.004

Cited by 16 publications

(16 citation statements)

References 26 publications

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“…Moreover, in our multiethnic cohort, the minority groups were previously found to have an increased risk for multiple diseases, including cardiovascular diseases and asthma ( Aarab et al, 2019 ; Perini et al, 2019 ). Therefore, the observed elevated CRP levels in four out of the five minority groups compared to the ethnic Dutch reference group are not unexpected.…”

Section: Discussionmentioning

confidence: 75%

Associations Between Child Maltreatment, Inflammation, and Comorbid Metabolic Syndrome to Depressed Mood in a Multiethnic Urban Population: The HELIUS Study

Willemen

Zuiden²,

Zantvoord³

et al. 2022

Front. Psychol.

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BackgroundChild maltreatment is a common negative experience and has potential long-lasting adverse consequences for mental and physical health, including increased risk for major depressive disorder (MDD) and metabolic syndrome. In addition, child maltreatment may increase the risk for comorbid physical health conditions to psychiatric conditions, with inflammation as an important mediator linking child maltreatment to poor adult health. However, it remains unresolved whether experiencing child maltreatment increases the risk for the development of comorbid metabolic syndrome to MDD. Therefore, we investigated whether child maltreatment increased the risk for comorbid metabolic syndrome to depressed mood. Subsequently, we examined whether C-reactive protein (CRP), as an inflammatory marker, mediated this association. In addition, we investigated whether effects differed between men and women.MethodsAssociations were examined within cross-sectional data from the multiethnic HELIUS study (N = 21,617). Adult residents of Amsterdam, Netherlands, self-reported on child maltreatment (distinct and total number of types experienced before the age of 16 years) as well as current depressed mood (PHQ-9 score ≥ 10), and underwent physical examination to assess metabolic syndrome. The CRP levels were assessed in N = 5,998 participants. Logistic and linear regressions were applied for binary and continuous outcomes, respectively. All analyses were adjusted for relevant demographic, socioeconomic, and lifestyle characteristics, including ethnicity.ResultsA higher number of maltreatment types as well as distinct types of emotional neglect, emotional abuse, and sexual abuse were significantly associated with a higher risk for current depressed mood. Child maltreatment was not significantly associated with the risk for metabolic syndrome in the whole cohort, nor within individuals with depressed mood. As child maltreatment was not significantly associated with the CRP levels, subsequent mediation analyses were not performed. No significant moderating effects by sex were observed.ConclusionIn this multiethnic urban cohort, child maltreatment was associated with a higher risk for depressed mood. Contrary to our expectations, child maltreatment was not significantly associated with an increased risk for metabolic syndrome, neither in the whole cohort nor as a comorbid condition in individuals with depressed mood. As the data were cross-sectional and came from a non-clinical adult population, longitudinal perspectives in relation to various stages of the investigated conditions were needed with more comprehensive assessments of inflammatory markers.

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Section: Discussionmentioning

confidence: 75%

Associations Between Child Maltreatment, Inflammation, and Comorbid Metabolic Syndrome to Depressed Mood in a Multiethnic Urban Population: The HELIUS Study

Willemen

Zuiden²,

Zantvoord³

et al. 2022

Front. Psychol.

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“…These differences were mostly explained by socioeconomic background differences or decreased physical exercise (31–33). Other studies also reported that, compared with Dutch adults, those of Surinamese, Moroccan, Turkish, or Antillean background are at increased risks of type 2 diabetes even when at normal weight (34,35). They also found that adults with a Turkish background had an unfavorable total/HDL cholesterol ratio, and adults with a Surinamese‐Creole background had an increased risk of hypertension (32,36–38).…”

Section: Discussionmentioning

confidence: 99%

Ethnic disparities in liver fat accumulation in school‐aged children

Groot

Geurtsen

Santos

et al. 2022

Obesity

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ObjectiveNonalcoholic fatty liver disease (NAFLD) has a different prevalence in adults from different ethnic groups. This study examined whether these ethnic differences originate in early life and could be explained by early‐life factors.MethodsThis observational study was embedded in a population‐based prospective cohort study from fetal life onward among 2,570 children born in Rotterdam, the Netherlands. Information about prepregnancy, pregnancy, and childhood factors, as well as childhood BMI, was obtained from questionnaires and physical examinations. Liver fat was assessed by magnetic resonance imaging at age 10 years.ResultsMedian liver fat fraction was 2.0% (95% CI: 1.2%‐5.3%), and NAFLD prevalence was 2.8%. Children from a Turkish background had the highest median liver fat percentage (2.5%, 95% CI: 1.2%‐10.7%) and NAFLD prevalence (9.1%). Children of Cape Verdean, Dutch Antillean, Surinamese‐Creole, or Turkish background had a higher total liver fat fraction compared with children with a Dutch background (p < 0.05). After controlling for early‐life factors, these differences persisted only in children with a Turkish background.ConclusionsPrevalence of liver fat accumulation and NAFLD differs between ethnic subgroups living in the Netherlands, especially for those with a Turkish background. Early‐life factors have a strong influence on these associations and may hold clues for future preventive strategies.

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“…It has been indicated that socioeconomic inequalities are more prevalent among minority ethnic populations who have high prevalence of CVD and related risk factors ( 24 ), and this inequality is growing globally ( 25 – 28 ). Ethnic minorities also experience more barriers to access a CVD diagnosis ( 29 ), poorer recording of clinical data ( 30 ), receive lower quality of health care, and have poorer health outcomes ( 31 ).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Disease and Mental Distress Among Ethnic Groups in Kyrgyzstan

Azfar

Dzhusupov²,

Orru

et al. 2021

Front. Public Health

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The purpose of this study was to characterize different ethnic groups in Kyrgyzstan regarding cardiovascular disease (CVD) and mental distress, and to investigate the association between CVD and mental distress. The mental distress was measured in terms of sleep disturbance, burnout, and stress.Materials and Methods: A cross-sectional study was carried out among six ethnic groups in Kyrgyzstan, aged 18 years and above. The sample was stratified for age, education, family status, and income. We used the Karolinska Sleep Questionnaire to assess sleep disturbance, the physical and emotional subscale of the Shirom Melamed Burnout Questionnaire to assess burnout, and the 10-item Perceived Stress Scale to assess perceived stress.Results: The distribution of CVD differed significantly between the six ethnic groups, with higher prevalence among East Europeans, and Western Asians and lower among Other minorities and Central Asians. In all ethnic groups in Kyrgyzstan, individuals with CVD had increased odds of sleep disturbance and burnout. There was a significant difference in burnout and stress between persons with and without CVD in Kyrgyz and East European ethnic groups.Conclusion: There was a significant difference in burnout and stress between persons with and without CVD in Kyrgyz and East European ethnic groups. In addition to CVD prevention, mitigating sleep disturbance and preventing burnout in the general population should be aimed at in public health measures.

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Ethnic differences in metabolic cardiovascular risk among normal weight individuals: Implications for cardiovascular risk screening. The HELIUS study

Cited by 16 publications

References 26 publications

Associations Between Child Maltreatment, Inflammation, and Comorbid Metabolic Syndrome to Depressed Mood in a Multiethnic Urban Population: The HELIUS Study

Associations Between Child Maltreatment, Inflammation, and Comorbid Metabolic Syndrome to Depressed Mood in a Multiethnic Urban Population: The HELIUS Study

Ethnic disparities in liver fat accumulation in school‐aged children

Cardiovascular Disease and Mental Distress Among Ethnic Groups in Kyrgyzstan

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