Ethnic differences in mammographic densities

Maskarinec, Gertraud; Meng, Lingfei; Ursin, Giske

doi:10.1093/ije/30.5.959

Cited by 131 publications

(110 citation statements)

References 30 publications

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“…We were also not able to detect the distinct change related to menopause (3%) described by Boyd et al (10) because we did not know the exact year of menopause. The determinants of mammographic densities observed in this report are very similar to those of other studies although we found no association with age at menarche and number of children (3,(5)(6)(7)36).…”

Section: Discussionsupporting

confidence: 90%

“…In understanding the association between risk factors and breast cancer development (1, 2), mammographic density is considered an intermediate end point because of its strong association with breast cancer (3,4) and its relation to established risk factors shown in numerous cross-sectional studies (5)(6)(7). Although breast cancer risk increases with age, breast density declines with age and menopause (3).…”

Section: Introductionmentioning

confidence: 99%

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A Longitudinal Investigation of Mammographic Density: The Multiethnic Cohort

Maskarinec

Pagano

Lurie

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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147

179

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Mammographic densities are hypothesized to reflect the cumulative exposure to risk factors that influence breast cancer incidence. This report analyzed percent densities over time and explored predictors of density change in relation to age. The study population consisted of 607 breast cancer cases and 667 frequency matched controls with 1,956 and 1,619 mammographic readings, respectively. Mammograms done over >20 years and before a diagnosis of breast cancer were assessed for densities using a computer-assisted method. Using multilevel modeling to allow for repeated measurements, we estimated the effect of ethnicity, case status, reproductive characteristics, hormonal therapy, body mass index, and soy intake on initial status and longitudinal change. After integrating the area under the percent density curve, cumulative percent density was compared with age-specific breast cancer rates in Hawaii. Percent densities decreased f5.6% per 10 years but a nonlinear effect indicated a faster decline earlier in life. Cumulative percent densities and age-specific breast cancer rates increased at very similar rates; both standardized regression coefficients were >0.9. Japanese ancestry, overweight, estrogen/progestin treatment, and, to a lesser degree, estrogen-only therapy predicted a slower decline in densities with age. Case status and adult soy intake were related to higher densities whereas overweight and having any child were associated with lower densities at initial status. Risk factors that influence the decline in mammographic densities over time may be important for breast cancer prevention because cumulative percent densities may reflect the age-related increase in breast cancer risk. (Cancer Epidemiol Biomarkers Prev 2006;15(4):732 -9)

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

A Longitudinal Investigation of Mammographic Density: The Multiethnic Cohort

Maskarinec

Pagano

Lurie

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

147

179

View full text Add to dashboard Cite

show abstract

“…However, the accuracy of mammography to detect breast cancer declines with increasing breast density (Kolb et al, 2002). Compared with Caucasian women, Asian women have higher breast densities relative to their smaller breast size, which lowers the accuracy of mammography to detect breast cancer in this population (Maskarinec et al, 2001). In a previous study, CBE in addition to mammography significantly decreased false-negative rates (Day, 2008).…”

Section: Discussionmentioning

confidence: 96%

Satisfaction in the National Cancer Screening Program for Breast Cancer with and without Clinical Breast Examination

Han

Jun

Choi

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The purpose of this study was to evaluate whether screening by clinical breast examination (CBE) in addition to mammography affected participant satisfaction in the National Cancer Screening Program (NCSP). Data were derived from the Quality Evaluation of National Cancer Screening satisfaction survey. This population-based nationwide telephone survey included participants who had been screened by the NCSP for breast cancer between June and August 2010 (n=2,370), and collected information on satisfaction with screening and screening service use. Five multiple regression models were used to determine satisfaction according to screening method, and according to each of five satisfaction measures (prescreening information transfer, staff interpersonal skills, physical surroundings, reporting of results and general satisfaction). A total of 1,858 (78.4%) participants were screened by mammography alone and 512 (21.6%) by both mammography and CBE. Satisfaction was significantly higher in subjects screened by both mammography and CBE compared with those screened by mammography alone.

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“…As we know, the incidence of breast cancer is different among populations. Several investigations detected some ethnic differences in mammographic densities as indicators of breast cancer risk [22,23]. Based on Table 2, PCOS group had three cases of breast cancer among the relatives and the control group had 12 cases of breast cancer among the relatives.…”

Section: Discussionmentioning

confidence: 99%