Ethmoid Adenocarcinoma—From Craniofacial to Endoscopic Resections

Nicolai, Piero; Villaret, Andrea Bolzoni; Bottazzoli, Marco; Rossi, Emanuela; Valsecchi, Maria Grazia

doi:10.1177/0194599811403873

Cited by 37 publications

(40 citation statements)

References 28 publications

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“…The 3-year and 5-year survival rates observed for the 43 patients are in accordance with published data [2,9,16]. Nodal and distant metastases were exclusively observed in the LR group.…”

Section: Discussionsupporting

confidence: 90%

“…Grosjean et al described the same results in an almost comparable study design but over a longer period (21 years) and including some patients without adjuvant RT [17]. Our rates of local failure for LR (21.7 %) and ESS (20 %) are comparable with the previous studies [9,11]. We observed, respectively, five and four local failures in LR and ESS groups with a very variable delay (mean: 31.6 months (from 8.5 to 56.5 months).…”

Section: Discussionsupporting

confidence: 86%

“…Nodal and distant metastases were exclusively observed in the LR group. As progression to lymph nodes or distant metastases is unfrequent due to the poor drainage to lymph vessels to the nasal cavities [9,14], these findings can be explained by a longer follow-up in the LR group. We showed that 3-year and 5-year DFS were not statistically different between LR and ESS, both associated with adjuvant RT.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies dealing with ADC often compare patients with different origins, different stages or histological subtypes pooled from several institutions [2] or included during a long period of time [9,10]. As long as complete extirpation of the tumour is achieved, the current debate in ADC management is about the most appropriate surgical approach.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

Mortuaire

Leroy

Vandenhende‐Szymanski

et al. 2016

Eur Arch Otorhinolaryngol

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Endoscopic sinus surgery (ESS) is considered as a valid option in the management of nasal adenocarcinoma (ADC). Comparative studies with open approaches are still required. A monocentric retrospective study was carried out from May 2002 to December 2013, including 43 patients with intestinal-type adenocarcinoma of the ethmoid sinus. Non-resectable tumours or recurrences were excluded. Before 2008, open approach with lateral rhinotomy (LR) was performed as the gold standard of treatment. From 2008, ESS was systematically used as a first-line option as long as a complete resection was achievable. Adjuvant radiation therapy was delivered (RT) for all the patients. LR and ESS were performed in, respectively, 23 and 20 patients. The two groups were comparable in terms of age, occupational dust exposure, histopathological subtypes, and T stage based on the pathological assessment of the specimen (10 pT2, 26 pT3, 2 pT4a, and 5 pT4b). The tumour origin was mainly located in the olfactory cleft with the involvement of the cribriform plate in 60 % of patients. No major complication was observed in ESS group with a reduced hospital stay (5.6 vs 7.6 days). The disease-free survival was not different between LR and ESS groups over a mean follow-up period of 6.6 years. Even for local advanced stages with skull base involvement, we confirm the reliability and the advantages of ESS in terms of oncological outcomes and morbidity. We advocate complete excision of the olfactory cleft to ensure an appropriate control of the tumoral origin.

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“…The 3-year and 5-year survival rates observed for the 43 patients are in accordance with published data [2,9,16]. Nodal and distant metastases were exclusively observed in the LR group.…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

Mortuaire

Leroy

Vandenhende‐Szymanski

et al. 2016

Eur Arch Otorhinolaryngol

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“…Endoscopic surgery seems a good surgical option since complete tumour extirpation is achieved, which depends not only in tumour stage, size and extension but in surgeon expertise and endoscopic facilities available. A series of 67 patients published in 2011, found external approaches to have higher risk of complications and death than endoscopically treated patients [16], however, no TNM stage stratification was made. More research with randomised and larger prospective studies is needed to clarify the potential benefits of endoscopic surgery in more advanced T-stage tumours.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinomas of the sinonasal tract: a case series from an Oncology Centre in Northern Portugal

Veloso-Teles

Ribeiro

Silva

et al. 2014

Eur Arch Otorhinolaryngol

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Sinonasal malignant neoplasms are rare and adenocarcinomas account for 10-20 % of these cancers. Our aim is to characterise the clinical presentation, risk factors and outcomes of patients with adenocarcinoma treated at our institution. Retrospective review of medical records of patients with sinonasal adenocarcinomas, treated at IPO-Porto from January 2008 until December 2012. Twenty-eight patients with adenocarcinomas were selected from a total of 53 patients with sinonasal cancers. There was a male predominance (93 %), a mean age at diagnosis of 56 years and a rate of occupational wood dust exposure of 71 %. The most common treatment option was surgery followed by adjuvant radiotherapy. The 5 year disease-free and cancer-specific survival was 58 and 60 %, respectively. The following factors had negative impact on disease-free survival: advanced AJCC stage (p = 0.014); skull base invasion (p = 0.002); poorly differentiated or mucinous subtypes histology (p = 0.034) and imaging findings of residual tumour before adjuvant radiotherapy (p < 0.001). Endoscopic tumour resection was not associated with adverse outcomes. The role of volume-modulated arch therapy in the treatment of sinonasal tumours has to be clarified. The higher rate of adenocarcinomas among sinonasal cancers in this series comparing with previous reports, even from our institution, suggests that this pathology is rising in Northern Portugal. Despite substantial local failure, sinonasal adenocarcinomas have a relatively favourable prognosis in terms of cancer-specific survival.

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Demographics and survival trends of sinonasal adenocarcinoma from 1973 to 2009

D’Aguillo

Kanumuri

Khan

et al. 2014

Int Forum Allergy Rhinol

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SNAC is a rare tumor classically associated with occupational exposure and carries a variable prognosis. This is the first dedicated large-scale, retrospective analysis of a North American SNAC population. SNAC appears to affect both males and females equally and predominantly affects whites. Patients categorized as other had significantly better survival outcomes, while gender appeared to have no significant effect on survival.

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Ethmoid Adenocarcinoma—From Craniofacial to Endoscopic Resections

Cited by 37 publications

References 28 publications

Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma

Adenocarcinomas of the sinonasal tract: a case series from an Oncology Centre in Northern Portugal

Demographics and survival trends of sinonasal adenocarcinoma from 1973 to 2009

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