Ethiopian traditional herbal drugs. Part III: Anti-fertility activity of 70 medicinal plants

Desta, Belachew

doi:10.1016/0378-8741(94)01187-7

Cited by 37 publications

(26 citation statements)

References 4 publications

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“…The dose for each animal was calculated considering the human dose (dry weight equivalent approximately 4 g/kg aqueous macerate employed as vaginal douche in divided doses) based on ethnomedical use of the plant part and the anti-implantation study of the alcoholic extract of the same part of the plant in a dose of 1.61 g/kg in rats (Desta, 1994).…”

Section: Test Materials Administrationmentioning

confidence: 99%

“…It is also used as hemostatic and oxytocic agents (Abebe and Ayehu, 1993). The preliminary studies on the root extract of the plant showed anti-implantation effect in rats (Desta, 1994). The present study was, therefore, carried out to identify the chemical constituents of the roots of Rumex steudelii, evaluate further its claimed antifertility effect using different models, and determine its oral LD 50 .…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical screening and pharmacological evaluations for the antifertility effect of the methanolic root extract of Rumex steudelii

Gebrie

Makonnen

Debella

et al. 2005

Journal of Ethnopharmacology

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Section: Test Materials Administrationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and pharmacological evaluations for the antifertility effect of the methanolic root extract of Rumex steudelii

Gebrie

Makonnen

Debella

et al. 2005

Journal of Ethnopharmacology

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“…Animals were examined the following morning for evidence of successful copulation. Animals with spermatozoa in vaginal smears or mucus plug were separated from male partners and this was considered day one of gestation (Desta, 1994). The mated animals were distributed into the treatment groups.…”

Section: Contraceptive Activitymentioning

confidence: 99%

Antifertility effects of <i>Pouzolzia Mixta</i> in female wistar rats

Sewani-Rusike¹

2013

Afr. J. Trad. Compl. Alt. Med.

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The continued use of plants by women to prevent pregnancy suggests there are plants out there with potential use as contraceptives. In Zimbabwe, Pouzolzia mixta is used as a "morning after" contraceptive, thus it may possess postcoital antifertility activity. To test contraceptive activity, animals (n=8/group) were orally pretreated with aqueous (AqPM) or ethanolic (EtPM) extract of P. mixta at 300mg/kg b.wt for 7 days followed by mating with continued treatment for 10 days post-conception. To test for postcoital activity, treatment was initiated on day-1 of pregnancy and continued for 10 days. Laparotomy was performed and implantations counted. For estrogenic activity, immature ovariectomised rats were treated for 7 days after which vaginal opening and uterine weights were determined. In vitro oxytocic effects were performed using uterine tissue in an organ bath with De Jalon's solution. Acetylcholine (Ach) was the positive control. Results showed modest contraceptive activity with EtPM more effective in inhibiting fertility compared to AqPM (37.5% vs 25%) with a similar trend for antiimplantation effects (31% vs 19%). There was potent postcoital antifertility effects with AqPM more effective in inhibiting implantation (94.6% vs 86%) and fertility (87.5% vs 75%) compared to EtPM. Immature rat bioassay for estrogenic activity demonstrated pronounced estrogenic activity by both extracts. Oxytocic effects at 400ng/ml were more pronounced for the AqPM (92% of 100ng/ml Ach) than EtPM (25% of 100ng/ml Ach). Findings demonstrate the antifertility effects of aqueous and ethanolic extracts of P. mixta. The antifertility effects may be attributed to antiimplantation, estrogenic and oxytocic effects of the plant extracts.

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“…Research notes other traditional uses for headache (as a dressing), paludism (malaria) ague fever, stomachache and diuretic. The smoke of the burning root is commonly inhaled for 'Satan beshita' or 'devil disease' (Asres, 2001;Desta, 1994).…”

Section: C) Eebicha (Vernonia Amygdalina)mentioning

confidence: 99%

Indigenous Wisdom and Folk Healing Practices among Urban Oromo of the Gibe Region in Ethiopia: A Case Study of Jimma and Agaro Towns

Edae

Mulu²

2017

IJMMU

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This folkloric study was aimed at documenting and exploring the utilization, spiritual and philosophical aspect and preparation of folk medicinal plants among the urban Oromo of the Gibe region with reference to Jimma and Agaro town. A total of 14 informants within the age group of 43 to 79 were interviewed several times on different folk medicinal plants. About 25 folk medicinal plants species were classified across 10 types, based on part of the plant used for medicinal purpose, have been documented with their scientific names in the study. The study indicate that folk medicinal plants used by the urban Oromo's are under serious risk due to external and internal influences. Modernization and acculturation have contributed a lot in making the younger generation unwilling to practice, utilize and preserve traditional knowledge in general and folk medicine in particular. Thus, attention should be given for the preservation of these plants and folk healer's wisdom.

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Ethiopian traditional herbal drugs. Part III: Anti-fertility activity of 70 medicinal plants

Cited by 37 publications

References 4 publications

Phytochemical screening and pharmacological evaluations for the antifertility effect of the methanolic root extract of Rumex steudelii

Phytochemical screening and pharmacological evaluations for the antifertility effect of the methanolic root extract of Rumex steudelii

Antifertility effects of <i>Pouzolzia Mixta</i> in female wistar rats

Indigenous Wisdom and Folk Healing Practices among Urban Oromo of the Gibe Region in Ethiopia: A Case Study of Jimma and Agaro Towns

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