Ethinyl estradiol vs estradiol valerate in combined oral contraceptives – Effect on glucose tolerance: A randomized, controlled clinical trial

Haverinen, Annina; Kangasniemi, Marika; Luiro, Kaisu; Piltonen, Terhi; Heikinheimo, Oskari; Tapanainen, Juha S.

doi:10.1016/j.contraception.2020.10.014

Cited by 12 publications

(15 citation statements)

References 38 publications

(48 reference statements)

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“…This study is a spin-off from a researcher-initiated randomized open-label trial conducted at the Helsinki and Oulu University Hospitals, Finland, between April 2015 and January 2018. The detailed study protocol has been described previously [17,20], and it was approved by the independent Ethics Committee of Helsinki University Central Hospital. The study was registered in the Clinical Trials database (NCT02352090; https://clinicaltrials.gov/) and the EU Clinical trials register (2014-001243-20; https://www.clinicaltrialsregister.eu).…”

Section: Methodsmentioning

confidence: 99%

“…All subjects provided informed consent via a signed form. The sample size calculation was based on glucose metabolism, the trials' primary outcome [20].…”

Section: Methodsmentioning

confidence: 99%

“…This spin-off study aimed to compare the effects of EE+DNG, EV+DNG, and DNG only on adrenal steroids and CBG. This work is part of a randomized trial comparing COCs containing EE and EV with the same progestin, primarily focusing on glucose metabolism [20].…”

Section: Introductionmentioning

confidence: 99%

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Effects of estradiol- and ethinylestradiol-based contraceptives on adrenal steroids: A randomized trial

et al. 2022

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Section: Methodsmentioning

confidence: 99%

“…All subjects provided informed consent via a signed form. The sample size calculation was based on glucose metabolism, the trials' primary outcome [20].…”

Section: Methodsmentioning

confidence: 99%

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Effects of estradiol- and ethinylestradiol-based contraceptives on adrenal steroids: A randomized trial

et al. 2022

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“…Some medical studies have shown no effect of COCs on fasting glucose and fasting insulin levels. Slight differences in fasting glucose level, HOMA-IR, ISI0 were not statistically significant [16], [17], [18]. In other studies there were no significant differences in the OGTT results between the groups.…”

Section: Lack Of Influence Of the Cocs On Carbohydrate Metabolism In ...mentioning

confidence: 90%

The influence of combined oral contraceptive pills on carbohydrate metabolism in healthy women and in women with PCOS - a systemic review

Wicha

Wierciszewki

Hawryluk

et al. 2022

J Educ Health Sport

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Introduction: Combined oral contraceptives (COCs) are a commonly used contraceptive method. They are used as one of the method therapy in women with PCOS. Outcomes from previous studies about the influence of the COCs on carbohydrate metabolism are diverse. Purpose: To assess the influence of combined oral contraceptives on parameters of carbohydrate metabolism in healthy women and in women with PCOS. Review methods: We conducted a systemic review according to PRISMA protocol. Databases as Pubmed, Scopus, Web of Science were screened systematically.The inclusion criteria were:a study published in 2016-2021, which contains information about the change of carbohydrate parameters as: fasting insulin, fasting glucose levels;HOMA-IR;insulin, glucose levels etc.The participants were healthy/PCOS women. Studies conducted on animals were excluded. The final number of studies enrolled in this study is 15. Abbreviated description of the state of knowledge: There are studies in which negative influences of the COCs on carbohydrate metabolism are proved. Nevertheless, many of these studies were conducted years ago.COCs, when they were introduced in 1960s, contained different compounds and amounts of hormones. Over the years a successive decrease in estrogen dose has occurred . Also progestogens have been developed in order to minimize the androgenic effects.Results of studies conducted nowadays are ambiguous. Summary: A significant impairment of carbohydrate metabolism in short period of time was not detected in healthy women. In women with PCOS the results depended on the type of COCs used.

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“…The study did not clarify which estrogen doses were used for the EE COC group 11 . E 2 V has also been shown to have a lower metabolic impact 12–14 …”

Section: Hormonal Contraceptionmentioning

confidence: 98%

Hormonal therapies and venous thrombosis: Considerations for prevention and management

LaVasseur

Neukam

Kartika

et al. 2022

Research and Practice in Thrombosis and Haemostasis

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Background: Venous thromboses are well-established complications of hormonal therapy. Thrombosis risk is seen with both hormonal contraceptive agents and with hormone replacement therapy for menopause and gender transition. Over the past several decades, large epidemiological studies have helped better define these risks.Objectives: To review and discuss the differences in thrombosis risk of the many of hormonal preparations available as well as their interaction with patient-specific factors. Methods:We conducted a narrative review of the available literature regarding venous thrombosis and hormonal therapies including for contraception, menopausal symptoms, and gender transition.Results: Thrombosis risk with estrogen-containing compounds increases with increasing systemic dose of estrogen. While progesterone-only-containing products are not associated with thrombosis, when paired with estrogen in combined oral contraceptives, the formulation of progesterone does impact the risk. These components, along with patient-specific factors, may influence the choice of hormonal preparation. For patients who develop thrombosis on hormonal treatment, anticoagulation is protective against future thrombosis. Duration of anticoagulation is dependent on ongoing and future hormone therapy choice. Finally, the optimal management of hormone therapy for individuals diagnosed with prothrombotic illnesses such as COVID-19 remains unclear.Conclusions: When contemplating hormonal contraception or hormone replacement therapy, clinicians must consider a variety of factors including hormone type, dose, route, personal and family history of thrombosis, and other prothrombotic risk factors to make informed, personalized decisions regarding the risk of venous thrombosis.

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Ethinyl estradiol vs estradiol valerate in combined oral contraceptives – Effect on glucose tolerance: A randomized, controlled clinical trial

Cited by 12 publications

References 38 publications

Effects of estradiol- and ethinylestradiol-based contraceptives on adrenal steroids: A randomized trial

Effects of estradiol- and ethinylestradiol-based contraceptives on adrenal steroids: A randomized trial

The influence of combined oral contraceptive pills on carbohydrate metabolism in healthy women and in women with PCOS - a systemic review

Hormonal therapies and venous thrombosis: Considerations for prevention and management

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