Ethical issues in clinical trials involving nanomedicine

Resnik, David B.; Tinkle, Sally S.

doi:10.1016/j.cct.2006.11.001

Cited by 91 publications

(50 citation statements)

References 33 publications

(45 reference statements)

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“…14 In short, nanomedicine is the application of nanotechnology to medicine, and two main types of nanomedicine products are currently in clinical trials: diagnostic tests and drug delivery devices. 15 Over the past decades, efforts have been focused on the development of nanomedicines such as nanoparticles, liposomes, nanoemulsions, or dendrimers for the specific delivery of drugs to the target tissues.…”

Section: Dovepressmentioning

confidence: 99%

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

403

269

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Section: Dovepressmentioning

confidence: 99%

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

403

269

View full text Add to dashboard Cite

“…Unfortunately, the safety of nanomaterials remains largely unknown or incompletely understood (Kumar, Zhang, and Liang 2013). This is currently the most critical issue obstructing the advance of nanomedical technology into clinical practice (Maojo et al 2012;Resnik and Tinkle 2007).…”

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confidence: 99%

Gold Nanoparticle Toxicity in Mice and Rats: Species Differences

et al. 2018

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Nanotoxicity studies are greatly needed to advance nanomedical technologies into clinical practice. We assessed the toxic effects of a single intravenous exposure to commercially available gold nanoparticles (GNPs) in mice and rats. Fifteen-nm GNPs were purchased and independently characterized. Animals were exposed to either 1,000 mg GNPs/kg body weight (GNP group) or phosphate-buffered saline. Subsets of animals were euthanized and samples collected at 1, 7, 14, 21, and 28 days postexposure. Independent characterization demonstrated that the physicochemical properties of the purchased GNPs were in good agreement with the information provided by the supplier. Mice exposed to GNPs developed granulomas in the liver and transiently increased serum levels of the pro-inflammatory cytokine interleukin-18. No such alterations were found in rats. While there was no fatality in mice post-GNP exposure, a number of the rats died within hours of GNP administration. Differences in GNP biodistribution and excretion were also detected between the two species, with rats having a higher relative accumulation of GNPs in spleen and greater fecal excretion. In conclusion, GNPs have the ability to incite a robust macrophage response in mice, and there are important species-specific differences in their biodistribution, excretion, and potential for toxicity.

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“…A new discipline known as nanotoxicology examines the effects of nanomaterials on organisms and the environment. [66][67][68] …”

Section: Ethical Issuesmentioning

confidence: 98%

Nanotechnology based devices and applications in medicine: An overview

Martis¹,

Badve²,

Degwekar³

2012

Chron Young Sci

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 68  "Nanotechnology" was first defined by Tokyo Science University, Norio Taniguchi in 1974. [8] Although the application of nanotechnology to medicine appears to be a relatively recent trend, the basic nanotechnology approaches for medical application dates back to several decades. [9] Lipid vesicles which were named as liposomes, were described in 1965, [10] in 1976 the description about the first controlled release polymer system of macromolecules was given, [11] Nanotechnology based devices and applications in medicine: An overview Abstract Nanotechnology has been the most explored and extensively studied area in recent times. Many devices which were earlier impossible to imagine, are being developed at a lightning speed with the application of nanotechnology. To overcome the challenges offered by the most dreaded diseases, such as cancer or any disease involving the central nervous system or other inaccessible areas of the human body, nanotechnology has been proved to be a boon in making the treatment more target specific and minimizing the toxicities. This review describes a handful of important devices and applications based on nanotechnology in medicine made in recent times. This article also describes in brief the regulatory concerns and the ethical issues pertaining to nanomedical devices.

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Ethical issues in clinical trials involving nanomedicine

Cited by 91 publications

References 33 publications

Nanomedicine in pulmonary delivery

Nanomedicine in pulmonary delivery

Gold Nanoparticle Toxicity in Mice and Rats: Species Differences

Nanotechnology based devices and applications in medicine: An overview

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