Nanotechnology based devices and applications in medicine: An overview

Martis, Elvis A. F.; Badve, Rewa R; Degwekar, Mukta D

doi:10.4103/2229-5186.94320

Cited by 46 publications

(15 citation statements)

References 46 publications

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“…Inorganic nanoparticles with their physical and chemical properties play an increasingly important role in the development of novel products that can be used in various biomedical, pharmaceutical, physical and biological applications . One of these groups of inorganic nanoparticles is metal nanoparticles, which are purely made from metal precursors like Cu, Ag and Au, etc.…”

Section: Introductionmentioning

confidence: 99%

“…[3] Inorganic nanoparticles with their physical and chemical properties play an increasingly important role in the development of novel products that can be used in various biomedical, pharmaceutical, physical and biological applications. [4][5][6] One of these groups of inorganic nanoparticles is metal nanoparticles, which are purely made from metal precursors like Cu, Ag and Au, etc. The advantages of metal nanoparticles are unique optoelectrical properties due to well-known localized surface plasmon resonance characteristics, and having a broad absorption band in the visible zone of the electromagnetic solar spectrum.…”

Section: Introductionmentioning

confidence: 99%

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Green synthesis of silver nanoparticles by using eugenol and evaluation of antimicrobial potential

Tekin

Guldu

Derviş

et al. 2019

Applied Organom Chemis

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The importance of green synthesis was revealed with advantages such as: eliminating the use of expensive chemicals; consume less energy; and generate environmentally benign products. With this aim, silver nanoparticles (AgNPs) were synthesized by using isolated eugenol from clove extract. Its antimicrobial potential was determined on three different microorganisms. Clove was extracted and eugenol was isolated from this extract. Green synthesis was performed and an anti‐microbial study was performed. All extraction and isolation analyses were performed by high‐performance liquid chromatography (HPLC); identification and confirmation were achieved using liquid chromatography–mass spectrometry (LC–MS); and scanning electron microscopy was used for characterization. Both HPLC and LC–MS analyses showed that eugenol obtained purely synthesized AgNPs and 20‐25‐nm‐sized and homogeneous shaped particles seen in images. The antimicrobial effects of AgNPs at eight concentrations were determinated against Staphylococcus aureus, Escherichia coli and Candida albicans, and maximum inhibition zone diameters were found as 2.6 cm, 2.4 cm and 1.5 cm, respectively. The results of the antimicrobial study showed that eugenol as a biological material brought higher antimicrobial effect to AgNPs in comparison to the other materials found in the literature.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver nanoparticles by using eugenol and evaluation of antimicrobial potential

Tekin

Guldu

Derviş

et al. 2019

Applied Organom Chemis

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“…About 30 years later, Gleiter et al launched the systematic study of nanoscopic materials, introducing the terms "nanocrystalline" and "nanocrystal" [3]. Due to their size-dependent physical and chemical properties [4], nanomaterials are spread over a wide range of applications in many areas of human activity, particularly in electronics [5][6][7][8], optics [9,10] and medicine [11][12][13]. For a long period of time, the interest in metal-based compounds was confined to oxides [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A Computational Study of AlF3 and ACF Surfaces

et al. 2018

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By applying first principles density functional theory (DFT) methods, different metal fluorides and their surfaces have been characterized. One of the most investigated metal fluorides is AlF3 in different polymorphs. Its chloride-doped analogon AlClxF3−x (ACF) has recently attracted much attention due to its application in catalysis. After presenting a summary of different first-principle studies on the bulk and surface properties of different main group fluorides, we will revisit the problem of the stability of different α -AlF3 surfaces and extend the investigation to chloride-doped counterparts to simulate the surface properties of amorphous ACF. For each material, we have considered ten different surface cuts with their respective terminations. We found that terminations of ( 01 1 ¯ 0 ) and ( 11 2 ¯ 0 ) yield the most stable surfaces for α -AlF3 and for the chlorine substituted surfaces. A potential equilibrium shape of the crystal for both α -AlF3 and ACF is visualized by a Wulff construction.

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“…Determining which of these compounds has the appropriate chemical characteristics as well as pharmacodynamic and pharmacokinetic properties is a resource and time-intensive task. 4 Large quantities of data from HTS projects, including the negative data (non-hits), are underutilised as a result of this. One way to make use of all the screening results is by analysing the data in parallel by employing in silico data mining algorithms.…”

Section: Introductionmentioning

confidence: 99%

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity

Wicht¹,

Combrinck²,

Smith³

et al. 2015

Bioorganic & Medicinal Chemistry

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A large quantity of high throughput screening (HTS) data for antimalarial activity has become available in recent years. This includes both phenotypic and target-based activity. Realising the maximum value of these data remains a challenge. In this respect, methods that allow such data to be used for virtual screening maximise efficiency and reduce costs. In this study both in vitro antimalarial activity and inhibitory data for β-haematin formation, largely obtained from publically available sources, has been used to develop Bayesian models for inhibitors of β-haematin formation and in vitro antimalarial activity. These models were used to screen two in silico compound libraries. In the first, the 1510 U.S. Food and Drug Administration approved drugs available on PubChem were ranked from highest to lowest Bayesian score based on a training set of β-haematin inhibiting compounds active against P. falciparum that did not include any of the clinical antimalarials or close analogues. The six known clinical antimalarials that inhibit β-haematin formation were ranked in the top 2.1% of compounds. Furthermore, the in vitro antimalarial hit-rate for this prioritised set of compounds was found to be 81% in the case of the subset where activity data are available in PubChem. In the second, a library of about 5,000 commercially available compounds (AldrichCPR) was virtually screened for ability to inhibit β-haematin formation and then for in vitro antimalarial activity. A selection of 34 compounds was purchased and tested, of which 24 were predicted to be β-haematin inhibitors. The hit rate for inhibition of β-haematin formation was found to be 25% and a third of these were active against P. falciparum, corresponding to enrichments estimated at about 25- and 140-fold relative to random screening, respectively.

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Nanotechnology based devices and applications in medicine: An overview

Cited by 46 publications

References 46 publications

Green synthesis of silver nanoparticles by using eugenol and evaluation of antimicrobial potential

Green synthesis of silver nanoparticles by using eugenol and evaluation of antimicrobial potential

A Computational Study of AlF3 and ACF Surfaces

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity

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