Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal  Carcinoma Cells

Kao, C. L.; Cho, Joshua; Lee, Ya-Zhe; Cheng, Yuan-Bin; Chien, Chih‐Yen; Hwang, Chung‐Feng; Hong, Yi‐Ren; Tseng, Chao-Neng; Cho, Chung-Lung

doi:10.3390/molecules200611508

Cited by 23 publications

(22 citation statements)

References 47 publications

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“…The roots of P. indica were prepared as a dried powder and deposited at the National Sun Yat-sen University (Kaohsiung, Taiwan, R.O.C.) and the H-PIRE was extracted using the method described by Kao et al (21). Briefly, the P. indica extract was prepared by immersing the root powder in 95% (v/v) ethanol at room temperature overnight, filtering with 0.45 µm filters, then partitioning the water and ethyl acetate (v/v, 1:1).…”

Section: Methodsmentioning

confidence: 99%

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Hexane fraction of Pluchea indica root extract inhibits proliferation and induces autophagy in human glioblastoma cells

et al. 2017

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Abstract. Pluchea indica (L.) Less. is a perennial plant known for its versatile uses in traditional medicine. Previous findings have shown that the extracts of Pluchea indica possess significant anti-inflammatory, anti-ulcer and anti-tuberculosis activity. The aim of this study was to demonstrate the anticancer activity of the hexane fraction of P. indica root extract (H-PIRE) in human glioblastoma cells using flow cytometric and western blot analysis. The results shoewd that, H-PIRE suppressed the growth of glioblastoma cells in a dose-dependent manner. H-PIRE treatment markedly decreased the population of cells in S and G2/M phases. The significant upregulation of acidic vesicular organelle (AVO) was detected during H-PIRE treatment. The expression levels of microtubule-associated light chain 3-II (LC3-II) protein, phosphorylated JNK and phosphorylated p38 were significantly increased, confirming the occurrence of autophagy during the process. Finally, the combination treatment of H-PIRE and LY294002, a pan PI3K inhibitor, further decreased cell viability, suggesting an additive anticancer effect. Taken together, our results suggest that H-PIRE suppresses the proliferation of glioblastoma cells by inducing cell cycle arrest and autophagy.

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Section: Methodsmentioning

confidence: 99%

“…Quinic acid esters from the leaves of P. indica showed inhibitory activities towards collagenase, MMP-2 and -9 (19). In vitro studies also revealed that crude aqueous extracts and ethanol extracts of P. indica root effectively suppress human malignant glioma cancer cells and human cervical cancer cells (20,21).…”

Section: Introductionmentioning

confidence: 95%

Hexane fraction of Pluchea indica root extract inhibits proliferation and induces autophagy in human glioblastoma cells

et al. 2017

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“…Cây cúc tần (Pluchea indica L.) thuộc chi Pluchea của họ Cúc-Asteraceae được dùng ở Việt Nam làm thuốc chữa cảm sốt, giúp tiêu hóa, chữa lỵ [1]. Các dịch chiết P. indica thể hiện nhiều hoạt tính sinh học như kháng các vi khuẩn Gram dương và Gram âm [2], chống viêm qua ức chế sự sản sinh NO [3], chống oxi hóa và ức chế enzym acetylcholine esterase [4], ức chế sự tăng sinh [5] hoặc gây sự chết theo chương trình của tế bào ung thư người [6]. Nhiều nghiên cứu trên thế giới cho thấy cây P. indica tích lũy các hợp chất sesquiterpen [7], flavonoid [8], lignan glycoside [7], acid caffeoyl quinic [9], dẫn xuất thiophen [2] và các sterol [10]; các hợp chất này cũng được thử nghiệm một số hoạt tính để tìm hiểu sự tương _______  Tác giả liên hệ.…”

Section: Mở đầU unclassified

Sterol, glycerol ester, and thiophene constituents from the twigs of Pluchea indica L. of Vietnam

Huong¹,

Giang²

2018

NST

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“…It is usually consumed as fresh vegetables, decoction, and topical medication. [6][7][8][9][10] Staphylococcus epidermidis (S. epidermidis) and Pseudomonas aeruginosa (P. aeruginosa) are two most prevalent bacterial pathogens infecting respiratory disease, urinary tract, eyes, and burn wounds. Their presence was associated with poor patient outcomes.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Pluchea indica and Piper betle Ethanol Extract on Staphylococcus epidermidis and Pseudomonas aeruginosa

Simanjuntak¹,

Yuniarni²,

Prayugo³

2016

PCPR

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Medicinal plants are widely used for the treatment of different infectious diseases. This study was aimed to investigate antibacterial activity of Pluchea indica (P. indica) and Piper betle (P.betle) ethanol extract on Staphylococcus epidermidis (S. epidermidis) and Pseudomonas aeruginosa (P. aeruginosa) using agar disk diffusion method. Ethanol extract of Piper betle showed more potent antibacterial activity than P. indica against S. Epidermidis with the highest inhibiton zone at 30.71 mm and 21.73 mm from 1 mg/ml concentration, respectively. In contrast, against P. aeruginosa, the ethanol extract of P. indica was more potent than P. betle with 21.44 mm and 20.12 mm of inhibition zone on 1 mg/ml concentration, respectively. There was no increased effect from the combination of these two extracts against these bacteria. When comparing the antibacterial activity of these extract with tetracycline as the standard, we found that antibacterial activity of P. indica at the concentration of 0.9 mg/ ml was comparable with that of tetracycline at concentration of 12.52 μg/ml, while P. betle needed 0.3 mg/ml concentration to had similar activity with 10.51 μg/ml of tetracycline. In conlusion, the antibacterial activity of ethanol extracts of P. indica and P. betle indicated that these extract had sufficient potential to warrant further examination and development as a new antibacterial agent.

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Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells

Cited by 23 publications

References 47 publications

Hexane fraction of Pluchea indica root extract inhibits proliferation and induces autophagy in human glioblastoma cells

Hexane fraction of Pluchea indica root extract inhibits proliferation and induces autophagy in human glioblastoma cells

Sterol, glycerol ester, and thiophene constituents from the twigs of Pluchea indica L. of Vietnam

Antibacterial Activity of Pluchea indica and Piper betle Ethanol Extract on Staphylococcus epidermidis and Pseudomonas aeruginosa

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