Ethanolic Extract of &lt;i&gt;Ocimum Grattissimum&lt;/i&gt; Leaves (Linn.) Rapidly Lowers Blood Glucose Levels in Diabetic Wistar Rats

Onaolapo, Adejoke Yetunde; Onaolapo, Olakunle James; Adewole, Stephen A

doi:10.3889/mjms.1857-5773.2011.0172

Cited by 17 publications

(7 citation statements)

References 29 publications

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“…It is traditionally used for the management of DM [52]. Intraperitoneal administration of 400 mg/kg bw/day of O. gratissimum methanolic leaf extract significantly decreased the blood glucose level in both normal and T1D models of rats by 56 % and 69 %, respectively [53,54]. Oral treatments at 500, 1000, and 1500 mg/kg bw/day of the aqueous leaf extract dropped the fasting blood glucose by more than 50 % [55].…”

Section: West Africamentioning

confidence: 99%

African Medicinal Plants with Antidiabetic Potentials: A Review

2014

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Diabetes mellitus is one of the major health problems in Africa. The conventional oral synthetic antidiabetic drugs available to manage the disease are costly and not readily affordable to the majority of the affected population. Interestingly, the continent is endowed with a tremendous number of medicinal plants that have been explored for their folkloric treatment of diabetes mellitus. Scientific investigations have validated the antidiabetic potentials of a number of these medicinal plants but there is no repository with information on these scientifically investigated plants as a guide for future research. In this review article, all of the in vivo antidiabetic studies conducted between January 2000 and July 2013 on African plants are systematically compiled with a closer look at some relevant plants from the continent?s subregions. Plants of the Asteraceae and Lamiaceae families are the most investigated, and West Africa has the highest number of investigated plants. Although promising results were reported in many cases, unfortunately, only a few studies reported the partial characterization of bioactive principles and/or mechanisms of action. It is hoped that government agencies, pharmaceutical industries, and the scientific community will have a look at some of these plants for future research and, if possible, subsequent commercialization.

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Section: West Africamentioning

confidence: 99%

African Medicinal Plants with Antidiabetic Potentials: A Review

2014

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“…The metformin group showed a reduction in the levels of these substances, indicating protection against renal injury or possible recovery. Effects of O. gratissimum on urea and creatinine mirrored its effect on the liver transaminases documented in a prior study [9]. There was a dose related increase in urea and creatinine which would indicate renal injury worse with increasing doses.…”

Section: Results Of Kidney Histopathologymentioning

confidence: 77%

“…In a previous publication we described the hepatotoxic potential of this extract in Wistar rats [9], however there is very little information on the effects of this herb on the kidney in the diabetic state; our intention here was to study the effects of O.gratissimum on kidney biochemistry and microanatomy in diabetic Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Ocimum Gratissimum Linn Worsens Streptozotocin-Induced Nephrotoxicity in Diabetic Wistar Rats

2012

Maced J Med Sci

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Effects of ethanolic extract of Ocimum gratissimum leaves (O. gratissimum) on the kidneys in Streptozotocin-induced diabetic rats were studied. Thirty-six adult rats were assigned into six groups (A, B, C, D, E and F) of six rats each. Diabetes was induced with a single intraperitoneal injection of Streptozotocin. Group A (non diabetic control) and F (diabetic control) received normal saline orally, group B received a Metformin at 25 mg/kg while groups C, D and E had O. gratissimum at 400, 600 and 800 mg/kg. Body weight and fasting blood glucose levels were monitored weekly; blood levels of Creatinine (Cr) and Urea (U) were measured on day twenty eight. Animals were sacrificed and kidney sections processed for histological study. Statistical analysis was carried out using a one way ANOVA followed by a post-hoc test. Results showed significant reduction in body weight and blood glucose levels in the groups that received either metformin or O.gratissimum as well as dose dependent increase in blood urea and creatinine levels, histopathology revealed varying degrees of renal injury. The study concluded that O. gratissimum worsens diabetes induced renal injury.

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“…DN is described as partial loss of kidney functions related to nephrotic syndrome, glomerulosclerosis, declining glomerular filtration rate (GFR), elevated arterial blood pressure, persistent albumin-urea and fluid retention [14]. The effect of glycogen accumulation in the kidney tubules which is the outcome of hyperglycemia is said to account for the DN disease progression [15]. The global rapid increase of DM has made DN the principal cause of end-stage renal disease.…”

Section: Introductionmentioning

confidence: 99%

Role of Vernonia Amygdalina on Plasma Lipid Profile, Liver and Kidney Enzymes in Rats with Streptozotocin-Induced Diabetes

Ajayi¹,

Uchechukwu²,

Elegbeleye³

et al. 2020

SJMH

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Diabetes mellitus is a non-communicable disease which has been associated with liver and kidney injuries, and at the same time affects lipid profiles. The aim of this study was to investigate the role of Vernonia amygdalina (VAM) on plasma lipid profile, liver and kidney enzymes in rats with streptozotocin -induced diabetes. Twenty-five male albino wistar rats weighing between 137 and 223 g were randomly grouped into five of five rats per group as follows: control, diabetic, diabetic + metformin (MET), diabetic + VAM at 150, 300 mg/kg. Diabetes was induced by administration of 45 mg/kg body weight streptozotocin (STZ) dissolved in citrate buffer (0.01 M, pH 4.5) by single intraperitoneal injection. Three days after, when diabetes was confirmed, MET and VAM were administered daily by oral gavage for 7 days. Animals were fasted overnight after the last administration of MET and VAM, sacrificed, blood was collected and plasma prepared for lipid profile estimation. Liver and kidney were collected, weighed, homogenized and supernatants obtained for enzymes and biochemical assays. There were no significant (p>0.05) change in the weights of animal, liver and kidney, liver/rat and kidney/rat ratios, plasma cholesterol (CHOL) concentration, activities of liver and kidney aspartate aminotransferase (AST), alanine aminotransferase (ALT), liver gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), and liver and kidney total protein (TPRO) concentrations; significant (p<0.05) decrease in triglyceride (TRIG), high density lipoprotein-cholesterol (HDL), low density lipoprotein-cholesterol (LDL), very low density lipoprotein-cholesterol (VLDL); and significant (p<0.05) increase in fasting blood glucose (FBG) level, kidney GGT, LDH activities, liver and kidney creatinine (CREA) and total bilirubin (TBIL) concentrations of diabetic (STZ) rats compared with normal control. The treatment of the diabetic rats with MET and VAM significantly modulated positively these parameters compared with the diabetic rats. This study further explains the protective role played by VAM in dyslipidaemia, liver and kidney injuries resulting from diabetes.

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Ethanolic Extract of <i>Ocimum Grattissimum</i> Leaves (Linn.) Rapidly Lowers Blood Glucose Levels in Diabetic Wistar Rats

Abstract: Background: The present study was undertaken to investigate the effects of ethanolic extracts of Ocimum gratissimum leaves on blood glucose and weight parameters in streptozotocin induced diabetic Wistar rats.

Cited by 17 publications

References 29 publications

African Medicinal Plants with Antidiabetic Potentials: A Review

African Medicinal Plants with Antidiabetic Potentials: A Review

Ocimum Gratissimum Linn Worsens Streptozotocin-Induced Nephrotoxicity in Diabetic Wistar Rats

Role of Vernonia Amygdalina on Plasma Lipid Profile, Liver and Kidney Enzymes in Rats with Streptozotocin-Induced Diabetes

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