Ethanol withdrawal tremor does not interact with physostigmine-induced tremor in rat

Animal Models of Tremor: Relevance to Human Tremor Disorders

“…In chemically induced animal models of tremor 69 – 81 ( Table 2 ), we found that agents working on the cholinergic axis are able to induce tremor. For example, agents that promote the cholinergic nervous system, such as oxotremorine, 70 arecoline, 70 nicotine, 75 pilocarpine, 72 and physostigmine, 74 can produce tremor in rodents. Interestingly, promoting muscarinic (oxotremorine), nicotinic (arecoline, pilocarpine, and nicotine), or both (physostigmine) types of cholinergic receptor systems can produce tremor, but whether the tremor characteristics differ in these animal models requires further investigation.…”