Ethanol's effects on auditory thresholds and reaction times during the acquisition of chronic ethanol self-administration in baboons

Hienz, Robert D.; Brady, Joseph V.; Bowers, Danielle A.; Ator, Nancy A.

doi:10.1016/0376-8716(89)90058-6

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…Furthermore, weight loss typically accompanies physical dependence to ethanol, and normal weights were maintained in this study (Ellis and Pick, 1970). Physical dependence has rarely been reported in other studies using oral ethanol self-administration or self-dosing models (Winger, 1988;Hienz et al, 1989;Katner et al, 2004;Meisch and Henningfield, 1977). A major advantage of this high-dose chronic self-dosing schedule is that it replicates human ''heavy drinking'' in a manner that produces consistent levels of intake and does not include the health risk, or discomfort to the animal, of extreme withdrawal symptoms.…”

Section: Discussionmentioning

confidence: 90%

“…The present study adapted a model of voluntary oral ethanol selfdosing that had been developed for use in baboons (Hienz et al, 1989). The ethanol self-dosing method itself had been adapted from methodologies used to engender and study oral ethanol self-administration in macaques and baboons, and has been demonstrated to produce reliable oral drug self-dosing in baboons prior to behavioral testing sessions Griffiths, 1983, 1997;Meisch and Henningfield, 1977;Henningfield et al, 1981;Turkkan et al, 1989).…”

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confidence: 98%

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Consistent, High‐Level Ethanol Consumption in Pig‐Tailed Macaques via a Multiple‐Session, Limited‐Intake, Oral Self‐Dosing Procedure

Weed

Wilcox

Ator

et al. 2008

Alcoholism Clin & Exp Res

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This model of multiple-session, limited access, oral ethanol self-dosing produced consistent, high-level ethanol consumption with each session qualifying as a "binge" drinking session using the definition of "binge" provided by the NIAAA (>80 mg/dl/session). This model of ethanol drinking in macaques will be of great utility in the study of immunological, physiological and behavioral effects of ethanol in nonhuman primates.

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Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 98%

Consistent, High‐Level Ethanol Consumption in Pig‐Tailed Macaques via a Multiple‐Session, Limited‐Intake, Oral Self‐Dosing Procedure

Weed

Wilcox

Ator

et al. 2008

Alcoholism Clin & Exp Res

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“…Alcohol also affected monaural thresholds to a greater degree than binaural ones. This frequency selective effect of alcohol may go some way towards explaining why some studies have reported that alcohol impaired auditory thresholds (Hansen, 1925, as cited in Schneider and Carpenter, 1969;Moody et al, 1980;Hienz et al, 1989Hienz et al, , 1992, whereas others did not (Schwab andEy, 1955 andBablik, 1968, as cited in Wallgren and Barry, 1970;also Specht, 1907, as cited in Schneider and Carpenter, 1969). It seems reasonable to suggest that the absence of effects of alcohol on audition in some of these studies was a consequence of the choice of stimuli.…”

Section: Discussionmentioning

confidence: 98%

“…However, behavioural studies of the effects on auditory thresholds (Schneider and Carpenter, 1969;Wallgren and Barry, 1970;Moody et al, 1980) have yielded equivocal findings. While several reviewers have concluded that there is little, if any, effect of alcohol on auditory detection thresholds (Jellinek and McFarland, 1940;Carpenter, 1962;Wallgren and Barry, 1970), recent studies using baboons suggest that auditory thresholds are increased by acute alcohol consumption (Hienz et al, 1989(Hienz et al, , 1992.…”

Section: Introductionmentioning

confidence: 99%

Frequency Selective Effects of Alcohol on Auditory Detection and Frequency Discrimination Thresholds

Pearson

Dawe

Timney

1999

Alcohol and Alcoholism

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In the first of two experiments, the effects of ethyl alcohol on monaural and binaural thresholds for pure tones were measured for a range of frequencies. The results showed a frequency-specific effect in which low frequencies were more severely affected than higher ones. Also, monaural thresholds tended to be more affected by alcohol than binaural ones. The second experiment extended this exploration by measuring frequency discrimination at several different frequencies. In this case, we also obtained a frequency-dependent effect: the increase in discrimination thresholds above 1000 Hz was three times greater than that for lower frequencies. The data suggest that the choice of stimuli may influence the ability to detect changes in auditory performance after alcohol and may account in part for the differences among earlier studies. The results are consistent with the hypothesis that alcohol is acting centrally, at the level of mechanisms involved in the temporal and binaural summation of auditory signals, rather than influencing peripheral structures.

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“…Although chronic excess alcohol intake has been associated with irreversible hearing loss (Rosenhall et al, 1993) and acute alcohol intake may temporarily impair auditory processing and worsen auditory thresholds (Fitzpatrick and Eviatar, 1980; Hienz et al, 1989; Kahkonen et al, 2005; Liu et al, 2004; Pearson et al, 1999; Robinette and Brey, 1978; Upile et al, 2007), some evidence suggests that long-term moderate alcohol intake may protect against hearing loss (Gopinath et al, 2010; Popelka et al, 2000). Reversible auditory changes that have been demonstrated following acute alcohol ingestion include temporary worsening of auditory thresholds, poorer speech discrimination, elevation of the acoustic reflex threshold, and impaired processing of tones, frequency change and novel sounds (Fitzpatrick and Eviatar, 1980; Kahkonen et al, 2005; Pearson et al, 1999; Robinette and Brey, 1978; Upile et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Prospective study of alcohol consumption and self-reported hearing loss in women

Curhan

Eavey

Wang

et al. 2015

Alcohol

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Chronic excess alcohol intake has been associated with irreversible hearing loss and acute alcohol intake may temporarily impair auditory function; however, some evidence suggests that long-term moderate alcohol intake may be related to lower risk of hearing loss. This study prospectively examined the association between total alcohol and individual alcoholic beverage consumption and risk of hearing loss in women. Data were prospectively collected from 65,424 participants in the Nurses’ Health Study II (NHS II) aged 27–44 years at baseline (follow-up 1991–2009). Alcohol consumption was assessed using a validated questionnaire every 4 years. An incident case was defined as self-reported hearing problem that began after 1991. Cox proportional hazards multivariate regression was used to adjust for potential confounders. During 1,024,555 person-years of follow-up, 12,384 cases of hearing loss occurred. After multivariate adjustment, there was no significant association between total alcohol consumption and risk of hearing loss. In exploratory analyses, beer consumption was associated with increased risk and wine consumption was associated with reduced risk. No significant association was observed for consumption of liquor. Total alcohol consumption is not associated with risk of hearing loss in women. The modest associations observed for beer (direct) and wine (inverse) may be due to chance or residual confounding but merit further study.

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Ethanol's effects on auditory thresholds and reaction times during the acquisition of chronic ethanol self-administration in baboons

Cited by 13 publications

References 25 publications

Consistent, High‐Level Ethanol Consumption in Pig‐Tailed Macaques via a Multiple‐Session, Limited‐Intake, Oral Self‐Dosing Procedure

Consistent, High‐Level Ethanol Consumption in Pig‐Tailed Macaques via a Multiple‐Session, Limited‐Intake, Oral Self‐Dosing Procedure

Frequency Selective Effects of Alcohol on Auditory Detection and Frequency Discrimination Thresholds

Prospective study of alcohol consumption and self-reported hearing loss in women

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