Ethanol modified supercritical carbon dioxide extraction of antioxidant rich extract from Pereskia bleo

Khan, Mohammad Sharif; Rahman, M. M.; Azmir, Jannatul; Shamsudin, Siti Hadijah; Uddin, Md. Azhar; Fahim, T.K.; Zaidul, I.S.M.

doi:10.1016/j.jiec.2014.05.047

Cited by 33 publications

(21 citation statements)

References 28 publications

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“…When low polarity compounds are removed in the first stage, mainly polar compounds will become available, which allows for the subsequent use of pressurized ethanol to more easily solubilize polar phenolics from the matrix; which could not be extracted in the first stage (ScCO 2 ). The processes where a previous extraction with ScCO 2 is done could promote changes in the interactions between the solutes and the residual matrix, which could later be extracted more easily with the use of polar solvents (Huang et al, 2013;Martinez-Correa et al, 2012;Sharif et al, 2015). Golmakani, Mohammadi, Ahmadzadeh Sani, and Kamali (2014) and Erdogan, Ates, Durmaz, Yilmaz, and Seckin (2011) reported a positive effect in the Total Phenolic Content, product of the increase of pressure in the extraction process with pressurized liquids.…”

Section: Chemical Compositionmentioning

confidence: 99%

Extracts from mango peel by-product obtained by supercritical CO2 and pressurized solvent processes

Garcia-Mendoza

Paula

Paviani

et al. 2015

LWT - Food Science and Technology

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Section: Chemical Compositionmentioning

confidence: 99%

Extracts from mango peel by-product obtained by supercritical CO2 and pressurized solvent processes

Garcia-Mendoza

Paula

Paviani

et al. 2015

LWT - Food Science and Technology

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“…The "phenolic compounds" expression embraces a considerable range of substances that possess an aromatic ring bearing one or more hydroxyl substituents. The structure of natural polyphenols varies from simple molecules, such as phenolic acids, to highly polymerized compounds, such as condensed tannins [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The substituent effect on the antioxidant capacity of catechols and resorcinols

2016

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effect. The combination of a double bond with a -COOH group, in the substituent, increases the BDE and reduces the electron donor capacity, and this result suggests that this combination induces a reduction in the antioxidant capacity in one polyphenol compound. In several reports, an intramolecular hydrogen bond has been proposed within to the most stable structure of catechol. However, by using arguments from the atoms in molecules approach and the electron localization function, we show that such an interaction is not relevant to stabilize this conformation and consequently and this is the reason that explains the unimportance of this interaction in the properties studied here and in previous studies.

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“…Based on Table 3, the main variables B (pressure) and C (extraction time) are significant whereas variable A (temperature) is not significant because its p-value exceeds 0.05 10 . The order of the effect strength of the variables on the response can be determined by comparing the t-values.…”

Section: Resultsmentioning

confidence: 99%

“…1(a), the yield shows a sharp increment with the increase in pressure. This is because when pressure is increased, the density of the supercritical fluid (CO 2 ) also increases, resulting in better solubility of compounds of the sample matrix in the solvent 10 . However, the extraction yield of extract was not affected by the increase in temperature.…”

Section: Resultsmentioning

confidence: 99%

Artocarpus altilis extracts as a food-borne pathogen and oxidation inhibitors: RSM, COSMO RS, and molecular docking approaches

Ahmad

Karim

Normaya

et al. 2020

Sci Rep

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Lipid oxidation and microbial contamination are the major factors contributing to food deterioration. Food additives like antioxidants and antibacterials can prevent food spoilage by delaying oxidation and preventing the growth of bacteria. Artocarpus altilis leaves exhibited biological properties that suggested its use as a new source of natural antioxidant and antimicrobial. Supercritical fluid extraction (SFE) was used to optimize the extraction of bioactive compounds from the leaves using response surface methodology (yield and antioxidant activity). The optimum SFE conditions were 50.5 °C temperature, 3784 psi pressure and 52 min extraction time. Verification test results (Tukey’s test) showed that no significant difference between the expected and experimental DPPH activity and yield value (99%) were found. Gas-chromatography –mass spectrometry (GC-MS) analysis revealed three major bioactive compounds existed in A. altilis extract. The extract demonstrated antioxidant and antibacterial properties with 2,3-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferric reducing ability of plasma (FRAP), hydroxyl radical scavenging activity, tyrosinase mushrrom inhibition of 41.5%, 8.15 ± 1.31 (µg of ascorbic acid equivalents), 32%, 37% and inhibition zone diameter of 0.766 ± 0.06 cm (B. cereus) and 1.27 ± 0.12 cm (E. coli). Conductor like screening model for real solvents (COSMO RS) was performed to explain the extraction mechanism of the major bioactive compounds during SFE. Molecular electrostatic potential (MEP) shows the probability site of nucleophilic and electrophilic attack during bacterial inhibition. Based on molecular docking study, non-covalent interactions are the main interaction occurring between the major bioactive compounds and bacteria (antibacterial inhibition).

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Ethanol modified supercritical carbon dioxide extraction of antioxidant rich extract from Pereskia bleo

Cited by 33 publications

References 28 publications

Extracts from mango peel by-product obtained by supercritical CO2 and pressurized solvent processes

Extracts from mango peel by-product obtained by supercritical CO2 and pressurized solvent processes

The substituent effect on the antioxidant capacity of catechols and resorcinols

Artocarpus altilis extracts as a food-borne pathogen and oxidation inhibitors: RSM, COSMO RS, and molecular docking approaches

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