Ethanol-induced disturbance in human arousal mechanism

Ethanol-Induced Alterations in Electroencephalographic Activity in Adult Males

“…1986;Ehlers et al 1989) and Fast Alama (Volavka et al 1985;Lukas et al 1989Lukas et al , 1990) frequency bands. Additionally, although we recorded signiftcant changes inEEG activity over frontal cortical regions, in contrast, other studies have often reported more widespread ethanol-induced EEG changes (Davis et al 1941;Holm berg and Marten 1955;Lehtinen et al 1978Lehtinen et al , 1981Volavka et al 1985;Ehlers and Schuckit 1988;Ehlers et al 1989;Lukas et al 1989Lukas et al , 1990.…”

“…In general, the increase in spectral magnitude in the SA frequency band has been described as the pri mary EEG response to ethanol ingestion (Davis et al 1941;Engel and Rosenbaum 1945;Holmberg and Mar tens 1955;Begleiter and Platz 1972;Lehtinen et al 1978;1981;Lukas et al 1986;Michel and Battig 1989), al though some studies reported that the changes in SA were accompanied by altered activity in theta (Lukas etal. 1986;Ehlers et al 1989) and Fast Alama (Volavka et al 1985;Lukas et al 1989Lukas et al , 1990) frequency bands.…”

“…The fact that Figure 2 shows no signifIcant difference between the HD and LD func tions suggests that a greater difference between doses may be necessary to elicit a signifIcant dose-dependent difference. However, even a greater difference between ethanol doses may not induce these effects as there is a high degree of inter-and intrasubject variability in both the blood-alcohol and EEG response to ethanol (Lehtinen et al 1981;Lukas et al 1986;Porjesz and Begleiter 1983).…”

“…The Fast Fourier Transform was used to calculate power spectral densities for each EEG recording. Measures of the relative areas under the power spectral curve were made for each of the KEY WORDS: Alpha; Beta; EEG; Power Spectra; Ethanol Investigations into the effects of acute ethanol adminis tration on adult, human electroencephalographic (EEG) activity have reported both decreases in the predomi nant baseline frequency and increases in power spec tral energy (Davis et al 1941;Engel and Rosenbaum, 1945;Holmberg and Martens, 1955;Begleiter and Platz 1972;Lehtinen et al 1981;Lukas et al 1986;Michel and Battig 1989). However, defIning the relationship be tween ethanol ingestion and its effect on the EEG is complicated by numerous variables whose influence…”

“…alcohol concentration and any measure of EEG acti Vity (Ehlers et al 1989). Lastly, Lehtinen et al (1981) POin te d out that an important factor in the relationship bet we en blood-alcohol level and changes in EEG activit y is whether the blood-alcohol level was measured dire ctly from the blood or indirectly from breathalyzer rea di n g s . Their study measured both values, but found that W hen breathalyzer blood-alcohol values were kept const ant by upward and downward adjustments of an intra ve.…”