Ethanol extract of Momordica tuberosa tubers protects liver in paracetamol-induced damage

Kumar, Prasanna; Rao, G. Devala; Lakshmayya, L; Ramachandra, Siddamsetty Setty

doi:10.2298/abs1004999k

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Application of A c c e p t e d M a n u s c r i p t 7 herbal medicine dates back to China for almost about 5000 years ago (45) . In recent past traditionally used medicinal plants are regaining their past recognition (46) and they have been used as natural remedies for the prevention and/or treatment of different ailments including liver disease (2,(47)(48)(49)(50)(51) .…”

Section: Natural Strategy For Hepatoprotectionmentioning

confidence: 99%

Include mushroom in daily diet—A strategy for better hepatic health

Chatterjee

Acharya

2015

Food Reviews International

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Liver, the most important metabolic organ of the body is also the major organ for the detoxification of the blood stream. If the accumulation of toxins is faster than their removal by liver, hepatic damage occurs. Although synthetic drugs are available in the market, long term use of such drugs has consequential side effects. Therefore, the growing need to find safe, costeffective drugs devoid of adverse effects is spawning extensive research. Mushrooms are rising as a major medicinal food and pharmaceuticals. This review summarizes the medicinal value of different edible mushrooms on free radical, xenobiotic and drug induced hepatotoxicity.

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Section: Natural Strategy For Hepatoprotectionmentioning

confidence: 99%

Include mushroom in daily diet—A strategy for better hepatic health

Chatterjee

Acharya

2015

Food Reviews International

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“…C-24 BL; REMI Laboratory systems, India). The supernatant of liver homogenates were used for the estimation of MDA lipid peroxidation, catalase (CAT), superoxide dismutase (SOD) and reduced glutathione (GSH) using methods described by Kumar et al (2010), Sahreen et al (2011), Marklund et al (1985 and Kaur et al (2006), respectively.…”

Section: Biochemical Determinationsmentioning

confidence: 99%

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Jaydeokar

Bandawane

Bibave

et al. 2014

Pharmaceutical Biology

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Context: Tarvada [Cassia auriculata Linn. (Caesalpiniaceae)] is used against liver ailments in Indian folk medicine, but there is a lack of scientific evidence for this traditional claim. Objective: The present study investigated the protective effect of methanol extract of tarvada (MECA) roots on ethanol and antitubercular drug induced hepatotoxicity in rats. Materials and methods: In the therapeutic model, ethanol (40%, 4 g/kg b.w., p.o.) was administered to rats for 21 days and the intoxicated rats were treated with MECA (300 and 600 mg/kg, b.w.) and silymarin (100 mg/kg, b.w.) for next 7 days. In the prophylactic model, MECA and silymarin were administered simultaneously along with a combination of isoniazid (27 mg/kg, b.w.), rifampicin (54 mg/kg, b.w.) and pyrazinamide (135 mg/kg, b.w.) for 30 days. After the study duration, serum levels of AST, ALT, ALP, total bilirubin, total cholesterol, total protein, albumin were estimated along with hepatic catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA) and liver histopathology in each group. Results: Administration of tarvada root extract significantly (p50.01 and p50.05) lowered the elevated levels of serum AST, ALT, ALP, total bilirubin, total cholesterol, total protein and restored the abnormal levels of enzymatic antioxidants and MDA in liver due to toxicant administration in a dose-dependent manner. These results were confirmed by histopathological analysis. Discussion and conclusion: Results suggest that tarvada root extract possess potent hepatoprotective activity against ethanol and antitubercular drug-induced hepatotoxicity in rats, which could be due to an inhibition of hepatic metabolizing enzymes and antioxidant activity.

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Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity

Nipate¹,

Tiwari²

2020

Journal of Ayurveda and Integrative Medicine

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Ethanol extract of Momordica tuberosa tubers protects liver in paracetamol-induced damage

Cited by 3 publications

References 12 publications

Include mushroom in daily diet—A strategy for better hepatic health

Include mushroom in daily diet—A strategy for better hepatic health

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity

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