Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity

Nipate, Sonali S.; Tiwari, Anand H.

doi:10.1016/j.jaim.2017.08.008

Cited by 10 publications

(5 citation statements)

References 31 publications

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“…There is less variability in the data in the test arm on days 8, 11 and 14 when compared to days 0 and 4 in the test arm as well as when compared to days 8, 11 and 14 in the control arm. The median values of total, physical and mental fatigue are substantially lower on day 4 (19,13,5), day 8 (15, 10, 5), day 11 (10,7,4) and day 14 (8,5,3), respectively, when compared to day 0 (26,18,8) in the test arm as well as when compared to day 4 (23,16,8), day 8 (22,15,7), day 11 (20,14,7) and day 14 (19.5, 14, 7) in the control arm (Figure 3). The outliers in the upper range of the test arm represent subjects that were still experiencing fatigue at the end of the 14-day treatment period.…”

Section: Analysis Of Efficacymentioning

confidence: 90%

“…A significant decrease in anxiety symptoms and modifications in the well-being status, inflammatory and oxidative indexes in CFS patients were seen with probiotics supplementation [ 12 , 13 ]. Antioxidants and immunomodulators have also been explored to combat fatigue [ 14 , 15 , 16 ]. Lactoferrin and enzymes such as lysozyme, catalase, bromelain and papain are known to function as immunomodulators [ 17 , 18 , 19 , 20 ] as well as in combating oxidative stress [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue

Rathi¹,

Jadhav²,

Shah

2021

Medicines

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Muscle fatigue and cognitive disturbances persist in patients after recovery from acute COVID-19 disease. However, there are no specific treatments for post-COVID fatigue. Objective: To evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3 (probiotic complex) in patients suffering from COVID-19 induced fatigue. A randomized, multicentric, double blind, placebo-controlled trial was conducted in 200 patients with a complaint of post-COVID fatigue. The test arm (n = 100) received the oral supplements for 14 days and the control arm (n = 100) received a placebo. Treatment efficacy was compared using the Chalder Fatigue scale (CFQ-11), at various time points from days 1 to 14. The supplemental treatment resulted in resolution of fatigue in a greater percentage of subjects in the test vs. the control arm (91% vs. 15%) on day 14. Subjects in the test arm showed a significantly greater reduction in total as well as physical and mental fatigue scores at all time points vs. the control arm. The supplements were well tolerated with no adverse events reported. This study demonstrates that a 14 days supplementation of ImmunoSEB + ProbioSEB CSC3 resolves post-COVID-19 fatigue and can improve patients’ functional status and quality of life.

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Section: Analysis Of Efficacymentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue

Rathi¹,

Jadhav²,

Shah

2021

Medicines

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“…Up to date, there are no generally acknowledged animal models, lipopolysaccharide/Brucella injection is the common method to induce chronic fatigue in animal models, which is based on infection or reactivation of a latent virus that does not match the actual causes of human suffering from sub-health. [26][27][28] In order to better simulate the actual situation of human sub-health formation, a few researchers created sub-health animal models by simulating the causes of human sub-health. In a study of Sisi Feng et al, a high fat and sugar diet, limbs restraints, and sleep deprivation can be used to establish a sub-health rat model.…”

Section: Discussionmentioning

confidence: 99%

Effects ofDendrobium officinaleultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

et al. 2022

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“…The pathogenesis of CCT includes neurodynamic and metabolic disorders of the central nervous system that are primarily related to hypoxic injury of the nervous tissue and results in the development of posthypoxic encephalopathy. Psychopathological syndrome is a common delayed consequence of CCT manifested in asthenic, neurotic, and neurosis-like disorders [5]. The severity of psychovegetative syndrome and emotional-and-intellectual disturbances progressively increases after CCT.…”

Section: Antihypoxants Antidepressants and Brain Injurymentioning

confidence: 99%

Hypoxia and antihypoxants, focus on brain injury

Shabanov

Zarubina

2019

Rev Clin Pharm Drug Ther

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Experiments on rats showed that the individual resistance of the body to acute hypoxia is of decisive importance in the early recovery period after mechanical craniocerebral trauma. Antihypoxant ethomersol administration (25 mg/kg, 3 days, intraperitoneally) following trauma decreased behavioral impairments in rats with different levels of resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disturbances in the brain. Monotherapy of consequences of craniocerebral trauma with antidepressant pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemithyl, an antihypoxant of benzimidazole structure, in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemithyl was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemithyl had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.

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Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity

Cited by 10 publications

References 31 publications

A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue

A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue

Effects ofDendrobium officinaleultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

Hypoxia and antihypoxants, focus on brain injury

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