Ethanol and opiate decrease the axonal transport of substance-P like immunoreactive material in rat vagus-nerves

Witte, Peter de; Hamon, Michel; Mauborgne, A.; François, Clément; Levy, C.; Laduron, Pierre M.

doi:10.1016/0143-4179(90)90024-s

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…The dose and duration of exposure can be precisely controlled, and the level of intoxication can be maintained relatively stable during entire course of exposure as well as from 1 cycle to another (Griffin et al, 2009b). Finally, the model allows animals to be treated simultaneously with other drugs such as acamprosate or rimonabant dissolved in drinking water (De Witte et al, 1990. Disadvantages: The model may not be ideal to study advanced alcohol-induced organ damage such as liver cirrhosis.…”

Section: In Vivo Models Of Chronic Alcohol Abusementioning

confidence: 99%

Laboratory Models Available to Study Alcohol‐Induced Organ Damage and Immune Variations: Choosing the Appropriate Model

El-Guindy

Kovacs

Witte

et al. 2010

Alcoholism Clin & Exp Res

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The morbidity and mortality resulting from alcohol-related diseases impose a substantive cost to society globally. To minimize the financial burden on society and improve the quality of life for individuals suffering from the ill effects of alcohol abuse, researchers in the alcohol field are focused on understanding the mechanisms by which alcohol-related diseases develop and progress. Since ethical concerns and inherent difficulties limit the amount of alcohol abuse research that can be performed in humans, most is performed in laboratory animals. This article summarizes the various laboratory models of alcohol abuse that are currently available and are used to study the mechanisms by which alcohol abuse induces organ damage and immune defects. The strengths and weaknesses of each of the models are discussed. Integrated into the review are the presentations that were made in the symposium “Methods of Ethanol Application in Alcohol Model – How Long is Long Enough” at the joint 2008 Research Society on Alcoholism (RSA) and International Society for Biomedical Research on Alcoholism (ISBRA) meeting, Washington, DC, emphasizing the importance not only of selecting the most appropriate laboratory alcohol model to address the specific goals of a project but also of ensuring that the findings can be extrapolated to alcohol-induced diseases in humans.

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Section: In Vivo Models Of Chronic Alcohol Abusementioning

confidence: 99%