Ethane: a marker of lipid peroxidation during cardiopulmonary bypass in humans

Andreoni, Kenneth A.; Kazui, M; Cameron, Duke E.; Nyhan, Daniel; Sehnert, Shelley S.; Rohde, Charles A.; Bulkley, Gregory B.; Risby, Terence H.

doi:10.1016/s0891-5849(98)00220-2

Cited by 42 publications

(33 citation statements)

References 12 publications

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“…However, malonyldialdehyde concentrations in systemic blood may reflect changes unrelated to cardiac oxidative stress (prostanoid synthesis [45], activity of aldehyde-dehydrogenase [35] and aldosereductase [36]). Indeed, surgery itself (independent of cardioplegic arrest/reperfusion) may induce systemic lipid peroxidation [18,44,46]. To specifically investigate lipid peroxidation at cardiac level, we simultaneously measured lipid peroxides in the blood entering the heart and in the coronary sinus effluent, and therefore could establish that no cardiac release of lipid peroxides occurred.…”

Section: Discussionmentioning

confidence: 99%

Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion

Milei¹,

Forcada²,

Fraga

et al. 2007

Cardiovasc Res

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Section: Discussionmentioning

confidence: 99%

Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion

Milei¹,

Forcada²,

Fraga

et al. 2007

Cardiovasc Res

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“…[15][16][17] An inverse correlation between ethane levels during reperfusion and post-bypass cardiac function has also been suggested. 8 In the present study, we did not attempt to correlate ethane levels to hemodynamic parameters. Nonetheless, the patients with the highest increases in exhaled ethane neither displayed any cardiovascular abnormalities nor could we demonstrate any correlation between ethane levels and acid-base parameters or hemoglobin levels during CPB.…”

Section: Discussionmentioning

confidence: 95%

“…On the contrary, Andreoni, et al reported an increase in exhaled ethane at 0-2 and 5-7 min sampling after the end of CPB. 8 Again, one might speculate that different temperatures during CPB and also differences in peri-operative management may explain different results.…”

Section: Discussionmentioning

confidence: 99%

“…This has also been shown previously, as increased levels of ethane were found in the breath of cardiac surgical patients after sternotomy, aortic clamp removal and termination of bypass. 8 However, in the latter study, ethane sampling was conducted over periods of several minutes, and one could potentially overlook ethane surges of short duration, or the surges could be "diluted" by the long sampling periods.…”

Section: Introductionmentioning

confidence: 99%

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Frequent sampling allows detection of short and rapid surges of exhaled ethane during cardiac surgery

et al. 2007

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During cardiopulmonary bypass (CPB), hypoperfusion and reperfusion may cause oxidative stress and lipid peroxidation that generates ethane. The aim of this pilot study was to assess the feasibility of frequent sampling of exhaled ethane during cardiac surgery. After approval of the Research Ethics Committee, 10 patients undergoing combined aortic valve and coronary artery bypass surgery were enrolled. Breath samples were drawn in the perioperative period and analyzed by a rapid, sensitive and validated gas-chromatographic method. Increased exhaled ethane was regularly seen following sternotomy, after the start of CPB and after aortic clamp removal, whereas no change was seen after termination of bypass. In one patient, the maximum increase in exhaled ethane was 30-fold. Peak durations lasted only 2-4 min. This study demonstrates that frequent sampling of breath ethane is feasible in a clinical setting, allowing detection of rapid ethane surges of short duration.

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“…However, mechanically ventilated patients suffering from any other disease than head injury are not suitable to serve as controls, since their disease (Cernak et al, 2000) may affect concentrations of lipid peroxidation markers. Neither can surgical patients in the operating room serve as controls since induction of anaesthesia and surgical procedures per se may increase exhaled pentane concentrations (Andreoni et al, 1999), and (volatile) anaesthetic agents in high concentrations very often interfere with pentane analysis.…”

Section: Scholpp Et Almentioning

confidence: 99%

Lipid Peroxidation Early after Brain Injury

Scholpp

Schubert

Miekisch

et al. 2004

Journal of Neurotrauma

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The role of lipid peroxidation after brain injury is still not completely understood, and results of different studies have been equivocal. In this study, three proposed peroxidation markers were determined in patients early after isolated head injury and results compared to healthy controls. Malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) were measured in plasma, and n-pentane was determined in patients' exhaled air. For MDA and TBARS no significant differences could be shown (0.267 vs. 0.358 ng/mL, and 0.896 vs. 0.814 ng/mL in patients vs. healthy volunteers, respectively). n-Pentane, however, was significantly increased in the expired air of patients (0.471 vs. 0.118 nmol/L in healthy volunteers). Similar results for n-pentane were obtained when only male patients and volunteers were considered (0.510 vs. 0.113 nmol/L). Stratification according to clinical outcome showed significantly higher values for n-pentane in male patients with poor outcome (0.656 nmol/L) in comparison with healthy male volunteers (0.113 nmol/L). No difference was found when patients were stratified according to the presence or absence of subarachnoid hemorrhage. It is concluded that, only in a sub-population of patients with brain injury, lipid-peroxidation is a crucial mechanism. n-Pentane seems to be a valuable marker to detect lipid peroxidation early after brain trauma. Malondialdehyde may be of value only later in the course of the disease. TBARS are not a specific marker and should therefore not be used.

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Ethane: a marker of lipid peroxidation during cardiopulmonary bypass in humans

Cited by 42 publications

References 12 publications

Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion

Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion

Frequent sampling allows detection of short and rapid surges of exhaled ethane during cardiac surgery

Lipid Peroxidation Early after Brain Injury

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