Etching Bulk Covalent Organic Frameworks into Nanoparticles of Uniform and Controllable Size by the Molecular Exchange Etching Method for Sonodynamic and Immune Combination Antitumor Therapy

Wang, Dianwei; Lin, Lin; Li, Tong; Meng, Meng; Hao, Kai; Guo, Zhaopei; Chen, Jie; Tian, Huayu; Chen, Xuesi

doi:10.1002/adma.202205924

Cited by 43 publications

(29 citation statements)

References 45 publications

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“…Covalent organic frameworks (COFs), which are crystalline porous polymeric materials with well-dened chemical structures, [25][26][27][28][29][30] have attracted extensive research interest in the tumor nanomedicine eld, and have been used in drug delivery, [31][32][33][34][35][36] phototherapy, [37][38][39][40][41][42][43][44][45][46] and immunotherapy [47][48][49][50][51][52] because they are versatile and biocompatible. Recently, AgI@COF-TpBpy was used as a delivery vehicle for radioiodine in brachytherapy, showing a long tumor retention time and effective cancer cell killing performance; 53 however, to our knowledge, the potential of a metal-free COF itself as a radiosensitizer in radiotherapy has not been exploited.…”

Section: Introductionmentioning

confidence: 99%

An iodide-containing covalent organic framework for enhanced radiotherapy

Dong

Zhou

et al. 2023

Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

An iodide-containing covalent organic framework for enhanced radiotherapy

Dong

Zhou

et al. 2023

Chem. Sci.

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“…TMB turns blue when encountering ·OH, so it was often used to detect whether materials could generate ·OH through Fenton or Fenton‐like effect. [ 20 ] Figure 2D showed the UV‐vis absorption spectra of the supernatants of COF and Cu‐COF mixed with H 2 O 2 . The photograph of the solution and the absorbance at 650 nm was shown in Figure 2E.…”

Section: Resultsmentioning

confidence: 99%

Copper‐Coordinated Covalent Organic Framework Produced a Robust Fenton‐Like Effect Inducing Immunogenic Cell Death of Tumors

Wang

Meng

et al. 2023

Macromol. Rapid Commun.

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Increasing infiltration of CD8+ T cells can enhance the response rate to immune checkpoint blockade (ICB) therapies. In contrast, immunogenic cell death (ICD) induced by intracellular reactive oxygen species (ROS) is an effective strategy to increase CD8 + T cell infiltration. Cuproptosis is newly defined and reported by Tsvetkov et al. A Cu-coordinated covalent organic framework (COF) in which two valence states of copper ions are simultaneously loaded is prepared. On the one hand, Cu 2+ undergoes a valence shift generating Cu + which acts as an effective Fenton-like reagent to catalyze the production of • OH and 1 O 2 from cellular overexpressed H 2 O 2 , causing DNA damage and lipid peroxidation (LPO), which directly produce cytotoxicity. On the other hand, residual Cu 2+ can effectively deplete endogenous cellular glutathione (GSH), converting it into glutathione disulfide (GSSG), further increasing intracellular oxidative stress and reducing the scavenging of ROS, thus further enhancing the Fenton-like effect and bringing toxic effects on tumor cells. The synergy of these two functions achieves ICD, helping for transforming "cold tumor" into "hot tumor" and efficient anti-tumor effects eventually. This work provides new insights into coordinated COF and inspire the development of more versatile COF for biomedical applications.

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“…As known to all, immunogenic cell death (ICD) can stimulate dendritic cells (CDs) and enhance serial anticancer immune activation. 36 To understand the adjuvanticity of the above treatments on anticancer immunity, in vivo DC maturity is investigated by evaluating CD80 and CD86 (typical co-stimulatory molecules) levels that are deemed as the markers of mature DC. The results of flow cytometric analyses reveal that DC maturation is enhanced after therapy.…”

Section: Immune Activation and Metastasis/recurrencementioning

confidence: 99%

Defect-Rich Ni–CoO@PEG Porous Hexagonal Nanosheets: Multi-enzyme and Ultrasound Catalysis for Synergistic Anticancer Treatment

Wang

Jia

et al. 2023

ACS Appl. Mater. Interfaces

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Given the similarity with photocatalysis, sonodynamic therapy (SDT) can be defined as ultrasonic (US) catalysis. Encouraged by the principles of photocatalysis and defect chemistry, defect-rich nickel (Ni)doped cobaltous oxide (Ni−CoO@PEG) porous hexagonal nanosheets have been synthesized as a sonosensitizer. The doping of Ni decreases the band gap that is testified by density functional theory to increase the US-generated charges. Under US irradiation, Ni−CoO@PEG nanosheets produce 1 O 2 as an active species that is determined by dissolved O 2 and electrons. Moreover, the doping also brings abundant oxygen vacancies (O V ) that not only are in favor of efficient separation of electron−hole but also enhance the interaction toward O 2 , boosting 1 O 2 generation. In addition, Ni−CoO@PEG shows robust mimic catalase (CAT) and peroxidase characterization to effectively improve the intratumor O 2 content and oxidation stress. What is more, the nanosheets also possess glucose oxidase activity that can consume glucose to elevate the H 2 O 2 /acid level and to block the intracellular energy supply. The tandem nanozyme behaviors would further regulate the tumor microenvironment for assisting anticancer treatment. It is noted that Ni−CoO@PEG reveals a novel half-metallic feature endowing great magnetism and magnetic resonance imaging capacity. The above synergistic treatments exhibit outstanding anticancer performance that also evokes antitumor immunity to suppress metastasis and recurrence, efficiently.

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Etching Bulk Covalent Organic Frameworks into Nanoparticles of Uniform and Controllable Size by the Molecular Exchange Etching Method for Sonodynamic and Immune Combination Antitumor Therapy

Cited by 43 publications

References 45 publications

An iodide-containing covalent organic framework for enhanced radiotherapy

An iodide-containing covalent organic framework for enhanced radiotherapy

Copper‐Coordinated Covalent Organic Framework Produced a Robust Fenton‐Like Effect Inducing Immunogenic Cell Death of Tumors

Defect-Rich Ni–CoO@PEG Porous Hexagonal Nanosheets: Multi-enzyme and Ultrasound Catalysis for Synergistic Anticancer Treatment

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