[Et₃NH][HSO₄]-catalyzed eco-friendly and expeditious synthesis of thiazolidine and oxazolidine derivatives

Abstract

Facile, sustainable and efficient synthesis of thiazolidine/oxazolidine derivatives.

Saturated Five-Membered Thiazolidines and Their Derivatives: From Synthesis to Biological Applications

“…Malla and colleagues [83] 4 ] is an inexpensive, eco-friendly catalyst, stable in water and air, exhibited both catalytic and medium engineering capability, is recyclable up to five runs without any significant loss of catalytic activity and also eliminated the additional use of the solvent. According to the possible reaction mechanism, initially, ionic liquid protonated the cyanates to furnish an intermediate, which underwent nucleophilic addition with 1,3-diketones and formed a new intermediate, which further reacted with ethylchloroacetate with consequent expulsion of HCl.…”

“…But there is no detailed review of the synthesis and biological activity of 4 Comparative study of various synthetic protocols [58][59][60][61][62][63][64][65][66][67][68][69] Fig. 5 Comparative study of various synthetic protocols [77][78][79][80][81][82][83][84][85][86] Topics in Current Chemistry (2020) 378:34 1 3 34 Page 8 of 90 hoping to inspire new and even more creative approaches for researchers ( Fig. 3).…”

Ionic Liquids—A Review of Their Toxicity to Living Organisms

“…ILs have been widely studied due to their unique properties, such as low flammability, negligible vapor pressure, high ionic conductivity, extensive liquid temperature range, high thermal and chemical stability, high solvation ability for organic, inorganic and organometallic compounds, selectivity and being easy recyclable through the separation from volatile compounds [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Due to these properties, ILs can be used in various areas from chemistry to engineering through the medical and the pharmaceutical fields, mainly as promising “green” alternatives to traditional organic solvents [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

An Efficient Method for the Synthesis of N‐uracil‐4‐oxo‐thiazolidines without Catalyst

“…The most well‐known and classical method for the synthesis of these compounds includes two‐component and three‐component reactions involving primary amines, an oxo‐compound and thiolic acids in the presence of diverse catalysts, such as hexafluorophosphate benzotriazole tetramethyl uronium , N , N ′‐dicyclohexylcarbodiimide , silica gel , [bmim][PF 6 ] , ZnCl 2 , ferrite , Hunig's base , [BmIm]OH , molecular sieves , sodium sulfate , montmorillonite K‐10 , nano‐Fe 3 O 4 @SiO 2 , [Et 3 NH][HSO 4 ] , DBSA , and baker's yeast .…”