Estudo químico e atividade antibacteriana do caule de Aristolochia esperanzae kuntze (Aristolochiaceae)

Pacheco, Alison Geraldo; Silva, Thiago M.; Manfrini, Rozângela Magalhães; Sallum, William S. T.; Duarte, Lucienir Pains; Piló‐Veloso, Dorila; Alcântara, Antônio F. C.; Knupp, Vagner Fernandes

doi:10.1590/s0100-40422010000800006

Cited by 14 publications

(5 citation statements)

References 8 publications

(12 reference statements)

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“…Electrospray ionization mass spectrometry (ESIMS) showed pseudomolecular ion signal at m/z 364.03 [M + Na] + and high resolution fast atom bombardment mass spectrometry (HR-FABMS) afforded M+1 ion signal at m/z 342.0620 which was corresponding to the molecular formula C 17 H 12 NO 7 (calculated for 342.06138). 1 H NMR and 3 C-NMR spectra were matched with those of AA-1 which were previously reported [28]. The correlation among each NMR signal was confirmed by 2D HSQC and HMBC.…”

Section: Resultssupporting

confidence: 78%

Activity of Aristolochia bracteolata against Moraxella catarrhalis

Mohamed

Idriss

Khedr

et al. 2014

International Journal of Bacteriology

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A bioassay-guided fractionation of methanol extract of Aristolochia bracteolata whole plant was carried out in order to evaluate its antimicrobial activity and to identify the active compounds in this extract. Antibacterial and antifungal activities of methanol extract against gram-positive, gram-negative, and fungal strains were investigated by the agar disk diffusion method. Among the strains tested, Moraxella catarrhalis and sea urchin-derived Bacillus sp. showed the highest sensitivity towards the methanol extract and hence they are used as test organisms for the bioassay-guided fractionation. From this extract, aristolochic acid 1 (AA-1) has been isolated and has showed the greatest antibacterial activity against both standard strain and clinical isolates of Moraxella catarrhalis with equal minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 25 and 50 μg/mL. Modification of the AA-1 to AA-1 methyl ester completely abolished the antibacterial activity of the compound and the piperonylic acid moiety of AA-1 which suggested that the coexistence of phenanthrene ring and free carboxylic acid is essential for AA-1 antibacterial activity.

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Section: Resultssupporting

confidence: 78%

Activity of Aristolochia bracteolata against Moraxella catarrhalis

Mohamed

Idriss

Khedr

et al. 2014

International Journal of Bacteriology

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“…The aristolochic acids, which are commonly found in plants of the genus Aristolochia [ 14 ], were not detected in the present study. Studies have shown that aristolochic acids have nephrotoxic, carcinogenic and mutagenic effects [ 15 , 16 , 17 ].…”

Section: Resultsmentioning

confidence: 99%

Essential Oil of Aristolochia trilobata: Synthesis, Routes of Exposure, Acute Toxicity, Binary Mixtures and Behavioral Effects on Leaf-Cutting Ants

et al. 2017

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Plants of the genus Aristolochia have been frequently reported as important medicinal plants. Despite their high bioactive potential, to date, there are no reports of their effects on leaf-cutting ants. Therefore, the present study aimed to evaluate the insecticidal activity of the essential oil of Aristolochia trilobata and its major components on Atta sexdens and Acromyrmex balzani, two species of leaf-cutting ants. The bioassays were performed regarding routes of exposure, acute toxicity, binary mixtures of the major components and behavioral effects. Twenty-five components were identified in the essential oil of A. trilobata using a gas chromatographic system equipped with a mass spectrometer and a flame ionization detector. The components found in higher proportions were sulcatyl acetate, limonene, p-cymene and linalool. The essential oil of A. trilobata and its individual major components were efficient against A. balzani and A. sexdens workers when applied by fumigation. These components showed fast and efficient insecticidal activity on ants. The components acted synergistically and additively on A. balzani and A. sexdens, respectively, and caused a strong repellency/irritability in the ants. Thus, our results demonstrate the great potential of the essential oil of A. trilobata and its major components for the development of new insecticides.

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“…Thus, several Aristolochia species have shown antimicrobial activity against panels of microrganisms. 5,6 The essential oil from the roots of A. orbicularis, composed by about 40 volatile compounds, showed high repellency against the corn borer Sitophilus zeamais. 7 The present study on the antimicrobial activity of Aristolochia orbicularis was performed as a part of an established program to investigate the antimicrobial potential of local medicinal plants.…”

mentioning

confidence: 99%

Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis

Rios

Navarro²,

Ramírez-Cisneros

et al. 2017

J. Nat. Prod.

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Six new compounds, aristoloxazine A (1), aristoloxazine B (2), 7-methoxytaliscanine (3), humul-7-en-1,4,11-triol (4), 8-hydroxy-β-logipinene (5), and 1β-hydroxy-4(14)-eudesmene (6), corresponding to two sulfur-containing aristoloxazines (1 and 2), an aristolactam (3), and three sesquiterpenes (4-6) were isolated, along with 26 known compounds, from the roots of Aristolochia orbicularis. The structures of the new compounds were established based on their spectroscopic and spectrometric data and in the case of aristoloxazine A (1) by single-crystal X-ray crystallography. This is the first report of sulfur-containing aristoloxazines from a natural source. Furthermore, aristoloxazine A (1) was found to possess potent in vitro antimicrobial activity against all resistant Staphylococcus aureus and several fungal strains in which it was evaluated.

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Estudo químico e atividade antibacteriana do caule de Aristolochia esperanzae kuntze (Aristolochiaceae)

Cited by 14 publications

References 8 publications

Activity of Aristolochia bracteolata against Moraxella catarrhalis

Activity of Aristolochia bracteolata against Moraxella catarrhalis

Essential Oil of Aristolochia trilobata: Synthesis, Routes of Exposure, Acute Toxicity, Binary Mixtures and Behavioral Effects on Leaf-Cutting Ants

Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis

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