Estudo Comparativo da Doença Coronariana Microvascular Causada por Doença de Chagas e por Outras Etiologias

Campos, Felipe Araujo; Magalhães, Mariana Lanna; Moreira, Henrique T.; Pavão, Rafael Brolio; Filho, Moysés Oliveira Lima; Lago, Igor Matos; Badran, André Vannuchi; Chierice, João Reynaldo Abbud; Schmidt, André; Neto, J A Marin

doi:10.36660/abc.20200381

Cited by 12 publications

(4 citation statements)

References 29 publications

(63 reference statements)

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“… 88 , 112 – 114 In a recent prospective study from Brazil, it was found that 15% of patients referred for diagnostic coronary angiograms had CD, with most of them not having evidence of obstructive epicardial coronary artery disease. 115 …”

Section: Microvascular Remodeling In Ccmmentioning

confidence: 99%

“…88,[112][113][114] In a recent prospective study from Brazil, it was found that 15% of patients referred for diagnostic coronary angiograms had CD, with most of them not having evidence of obstructive epicardial coronary artery disease. 115 Several studies have demonstrated both reversible and fixed MPD at various stages of CCM. 116,117 Additionally, in patients with CCM and malignant ventricular arrhythmias, MPD regions have demonstrated local myocardial sympathetic denervation.…”

Section: Evidence Of Microvascular Remodeling Derangements From Clini...mentioning

confidence: 99%

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Arrhythmogenic Manifestations of Chagas Disease: Perspectives From the Bench to Bedside

Roman-Campos,

Marin-Neto,

Santos-Miranda

et al. 2024

Circulation Research

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Chagas cardiomyopathy caused by infection with the intracellular parasite Trypanosoma cruzi is the most common and severe expression of human Chagas disease. Heart failure, systemic and pulmonary thromboembolism, arrhythmia, and sudden cardiac death are the principal clinical manifestations of Chagas cardiomyopathy. Ventricular arrhythmias contribute significantly to morbidity and mortality and are the major cause of sudden cardiac death. Significant gaps still exist in the understanding of the pathogenesis mechanisms underlying the arrhythmogenic manifestations of Chagas cardiomyopathy. This article will review the data from experimental studies and translate those findings to draw hypotheses about clinical observations. Human- and animal-based studies at molecular, cellular, tissue, and organ levels suggest 5 main pillars of remodeling caused by the interaction of host and parasite: immunologic, electrical, autonomic, microvascular, and contractile. Integrating these 5 remodeling processes will bring insights into the current knowledge in the field, highlighting some key features for future management of this arrhythmogenic disease.

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Section: Microvascular Remodeling In Ccmmentioning

confidence: 99%

Section: Evidence Of Microvascular Remodeling Derangements From Clini...mentioning

confidence: 99%

Arrhythmogenic Manifestations of Chagas Disease: Perspectives From the Bench to Bedside

Roman-Campos,

Marin-Neto,

Santos-Miranda

et al. 2024

Circulation Research

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show abstract

“… 33 Estima‐se que 20‐40% dos pacientes com cardiopatia chagásica tenham angina atípica decorrentes de anormalidades na perfusão miocárdica provocadas pelo exercício e reversíveis com o repouso, provavelmente associadas com isquemia microvascular. Campos et al 34 compararam pacientes com isquemia microvascular relacionada à doença de Chagas com pacientes com isquemia microvascular decorrentes de outras etiologias. Concluíram que os dois grupos tiveram características clínicas, hemodinâmicas e de perfusão miocárdica semelhantes, mas a disfunção global e segmentar do ventrículo esquerdo foi mais grave nos pacientes com isquemia microvascular relacionada com a doença de Chagas.…”

Section: Insuficiência Cardíaca E Cardiomiopatiaunclassified

“…Análise de >100.000 Cirurgias Cardiovasculares Realizadas no Instituto do Coração e a Nova Era com foco nos resultados http://abccardiol.org/wp‐content/uploads/articles_xml/0066‐782X‐abc‐S0066‐782X2020000400603/0066‐782X‐abc‐S0066‐782X2020000400603‐pt.x64000.pdf Alves 22 5. Hospitalização por infarto agudo do miocárdio: um registro de base populacional http://abccardiol.org/wp‐content/uploads/articles_xml/1678‐4170‐abc‐115‐05‐0916/1678‐4170‐abc‐115‐05‐0916.x64000.pdf Campos 34 6. Estudo comparativo da doença coronariana microvascular causada por doença de Chagas com outras etiologias http://abccardiol.org/wp‐content/uploads/articles_xml/0066‐782X‐abc‐115‐06‐1094/0066‐782X‐abc‐115‐06‐1094.x64000.pdf Stefan 32 7.…”

Section: Introductionunclassified

O Melhor do Ano 2020 nos Arquivos Brasileiros de Cardiologia e na Revista Portuguesa de Cardiologia

Fontes‐Carvalho¹,

Oliveira²,

Cardim³

et al. 2021

Revista Portuguesa de Cardiologia

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Development and diseases of the coronary microvasculature and its communication with the myocardium

Neffeová

Olejníčková

Naňka

et al. 2022

WIREs Mechanisms of Disease

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We review the current understanding of formation and development of the coronary microvasculature which supplies oxygen and nutrients to the heart myocardium and removes waste. We emphasize the close relationship, mutual development, and communication between microvasculature endothelial cells and surrounding cardiomyocytes. The first part of the review is focused on formation of microvasculature during embryonic development. We summarize knowledge about establishing the heart microvasculature density based on diffusion distance. Then signaling mechanisms which are involved in forming the microvasculature are discussed. This includes details of cardiomyocyte—endothelial cell interactions involving hypoxia, VEGF, NOTCH, angiopoietin, PDGF, and other signaling factors. The microvasculature is understudied due to difficulties in its visualization. Therefore, currently available imaging methods to delineate the coronary microvasculature in development and in adults are discussed. The second part of the review is dedicated to the importance of the coronary vasculature in disease. Coronary microvasculature pathologies are present in many congenital heart diseases (CHD), especially in pulmonary atresia, and worsen outcomes. In CHDs, where the development of the myocardium is impaired, microvasculature is also affected. In adult patients coronary microvascular disease is one of the main causes of sudden cardiac death, especially in women. Coronary microvasculature pathologies affect myocardial ischemia and vice versa; myocardial pathologies such as cardiomyopathies are closely connected with coronary microvasculature dysfunction. Microvasculature inflammation also worsens the outcomes of COVID‐19 disease. Our review stresses the importance of coronary microvasculature and provides an overview of its formation and signaling mechanisms and the importance of coronary vasculature pathologies in CHDs and adult diseases. This article is categorized under: Cardiovascular Diseases > Stem Cells and Development Congenital Diseases > Molecular and Cellular Physiology Cardiovascular Diseases > Molecular and Cellular Physiology

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Estudo Comparativo da Doença Coronariana Microvascular Causada por Doença de Chagas e por Outras Etiologias

Cited by 12 publications

References 29 publications

Arrhythmogenic Manifestations of Chagas Disease: Perspectives From the Bench to Bedside

Arrhythmogenic Manifestations of Chagas Disease: Perspectives From the Bench to Bedside

O Melhor do Ano 2020 nos Arquivos Brasileiros de Cardiologia e na Revista Portuguesa de Cardiologia

Development and diseases of the coronary microvasculature and its communication with the myocardium

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